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Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes.
Am J Med Sci. 2018 Jun; 355(6):573-580.AJ

Abstract

Joint hypermobility is a common, primarily benign finding in the general population. However, in a subset of individuals joint hypermobility causes a range of clinical problems mainly affecting the musculoskeletal system and, to a lesser extent, extra-articular disorders. Joint hypermobility often appears as a familial trait and is shared by several inherited connective tissue disorders, including the hypermobility subtype of Ehlers-Danlos syndrome (hEDS) and benign joint hypermobility syndrome (BJHS/JHS). Although joint hypermobility has primarily been thought of as a rheumatological disorder, increasing evidence shows significant associations between both hEDS and BJHS with specific extra-articular disorders. To date, the strongest associations of these 2 conditions are with anxiety disorders, orthostatic tachycardia, various functional gastrointestinal (GI) disorders and pelvic and bladder dysfunction. This review article focuses on GI disorders associated with both hEDS and BJHS. The aim of this review is to evaluate existing research and literature regarding associations between JHS (hEDS/BJHS) and GI disorders. Our goal is to raise awareness of BJHS/JHS and hEDS as an explanation for chronic unexplained symptoms and functional GI disorders as well as to review the current standard tests available for proper evaluation of GI symptoms in these patients.

Authors+Show Affiliations

Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas.Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas.Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Division of Cardiology, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Department of Internal Medicine, Texas Tech University Health Sciences Center Paul L. Foster School of Medicine, El Paso, Texas.Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso, Texas. Electronic address: richard.mccallum@ttuhsc.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29891041

Citation

Botrus, Gehan, et al. "Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes." The American Journal of the Medical Sciences, vol. 355, no. 6, 2018, pp. 573-580.
Botrus G, Baker O, Borrego E, et al. Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes. Am J Med Sci. 2018;355(6):573-580.
Botrus, G., Baker, O., Borrego, E., Ngamdu, K. S., Teleb, M., Gonzales Martinez, J. L., Maldonado, G., Hussein, A. M., & McCallum, R. (2018). Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes. The American Journal of the Medical Sciences, 355(6), 573-580. https://doi.org/10.1016/j.amjms.2018.03.001
Botrus G, et al. Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes. Am J Med Sci. 2018;355(6):573-580. PubMed PMID: 29891041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectrum of Gastrointestinal Manifestations in Joint Hypermobility Syndromes. AU - Botrus,Gehan, AU - Baker,Omar, AU - Borrego,Erica, AU - Ngamdu,Kyari Sumayin, AU - Teleb,Mohamed, AU - Gonzales Martinez,Jose L, AU - Maldonado,Gerardo,3rd AU - Hussein,Ahmed M, AU - McCallum,Richard, Y1 - 2018/03/05/ PY - 2017/07/22/received PY - 2018/02/20/revised PY - 2018/03/01/accepted PY - 2018/6/13/entrez PY - 2018/6/13/pubmed PY - 2018/12/12/medline KW - Benign joint hypermobility syndrome KW - Ehlers-Danlos syndrome KW - Joint hypermobility SP - 573 EP - 580 JF - The American journal of the medical sciences JO - Am. J. Med. Sci. VL - 355 IS - 6 N2 - Joint hypermobility is a common, primarily benign finding in the general population. However, in a subset of individuals joint hypermobility causes a range of clinical problems mainly affecting the musculoskeletal system and, to a lesser extent, extra-articular disorders. Joint hypermobility often appears as a familial trait and is shared by several inherited connective tissue disorders, including the hypermobility subtype of Ehlers-Danlos syndrome (hEDS) and benign joint hypermobility syndrome (BJHS/JHS). Although joint hypermobility has primarily been thought of as a rheumatological disorder, increasing evidence shows significant associations between both hEDS and BJHS with specific extra-articular disorders. To date, the strongest associations of these 2 conditions are with anxiety disorders, orthostatic tachycardia, various functional gastrointestinal (GI) disorders and pelvic and bladder dysfunction. This review article focuses on GI disorders associated with both hEDS and BJHS. The aim of this review is to evaluate existing research and literature regarding associations between JHS (hEDS/BJHS) and GI disorders. Our goal is to raise awareness of BJHS/JHS and hEDS as an explanation for chronic unexplained symptoms and functional GI disorders as well as to review the current standard tests available for proper evaluation of GI symptoms in these patients. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/29891041/Spectrum_of_Gastrointestinal_Manifestations_in_Joint_Hypermobility_Syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(18)30085-5 DB - PRIME DP - Unbound Medicine ER -