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Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration.
Curr Nutr Rep. 2018 06; 7(2):49-57.CN

Abstract

PURPOSE OF REVIEW

This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.

RECENT FINDINGS

Recent evidence indicates that plant-derived flavonoids may exert powerful actions on mammalian cognition and protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects of flavonoids have been suggested to be due to interactions with the cellular and molecular architecture of brain regions responsible for memory. Mechanisms for the beneficial effects of flavonoids on age-related cognitive decline and dementia are discussed, including modulating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation, promoting vascular effects capable of stimulating new nerve cell growth in the hippocampus, bidirectional interactions with gut microbiota and attenuating the extracellular accumulation of pathological proteins. These processes are known to be important in maintaining optimal neuronal function and preventing age-related cognitive decline and neurodegeneration.

Authors+Show Affiliations

Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7UQ, UK.Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7UQ, UK.Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7UQ, UK.Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, NR4 7UQ, UK. D.Vauzour@uea.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29892788

Citation

Flanagan, Emma, et al. "Impact of Flavonoids On Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration." Current Nutrition Reports, vol. 7, no. 2, 2018, pp. 49-57.
Flanagan E, Müller M, Hornberger M, et al. Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration. Curr Nutr Rep. 2018;7(2):49-57.
Flanagan, E., Müller, M., Hornberger, M., & Vauzour, D. (2018). Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration. Current Nutrition Reports, 7(2), 49-57. https://doi.org/10.1007/s13668-018-0226-1
Flanagan E, et al. Impact of Flavonoids On Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration. Curr Nutr Rep. 2018;7(2):49-57. PubMed PMID: 29892788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration. AU - Flanagan,Emma, AU - Müller,Michael, AU - Hornberger,Michael, AU - Vauzour,David, PY - 2018/6/13/entrez PY - 2018/6/13/pubmed PY - 2019/7/19/medline KW - Alzheimer’s disease KW - Memory KW - Microbiome KW - Polyphenols KW - Signalling pathways SP - 49 EP - 57 JF - Current nutrition reports JO - Curr Nutr Rep VL - 7 IS - 2 N2 - PURPOSE OF REVIEW: This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases. RECENT FINDINGS: Recent evidence indicates that plant-derived flavonoids may exert powerful actions on mammalian cognition and protect against the development of age-related cognitive decline and pathological neurodegeneration. The neuroprotective effects of flavonoids have been suggested to be due to interactions with the cellular and molecular architecture of brain regions responsible for memory. Mechanisms for the beneficial effects of flavonoids on age-related cognitive decline and dementia are discussed, including modulating signalling pathways critical in controlling synaptic plasticity, reducing neuroinflammation, promoting vascular effects capable of stimulating new nerve cell growth in the hippocampus, bidirectional interactions with gut microbiota and attenuating the extracellular accumulation of pathological proteins. These processes are known to be important in maintaining optimal neuronal function and preventing age-related cognitive decline and neurodegeneration. SN - 2161-3311 UR - https://www.unboundmedicine.com/medline/citation/29892788/Impact_of_Flavonoids_on_Cellular_and_Molecular_Mechanisms_Underlying_Age_Related_Cognitive_Decline_and_Neurodegeneration_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29892788/ DB - PRIME DP - Unbound Medicine ER -