Tags

Type your tag names separated by a space and hit enter

Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline.
Curr Nutr Rep. 2018 06; 7(2):39-48.CN

Abstract

PURPOSE OF REVIEW

Evidence suggests that flavonoids, polyphenolic compounds found in many plant-derived foods, such as berries, may allay cognitive impairment. We review recent research exploring the protective effects of flavonoids on age-related cognitive decline and neurodegenerative disorders in humans and animals. We also address the mechanisms by which flavonoids may exert their effects and promising avenues of future research.

RECENT FINDINGS

Flavonoids have been found to decrease neuroinflammation, reduce oxidative stress, and mediate neuroplasticity in animal models of neurodegeneration and aging. Injecting flavonoids encased in metal nanoparticles may further enhance the efficacy of flavonoids. Animal studies also demonstrate that flavonoid supplementation may alleviate neurodegenerative cognitive and memory impairments. Limited human studies, however, demonstrate the need for further clinical research investigating flavonoids. Flavonoid supplementation, as well as dietary modification to include whole foods high in flavonoids, may provide therapeutic potential for aging individuals experiencing cognitive deficits resulting from neurodegeneration.

Authors+Show Affiliations

Department of Psychology, Simmons College, 300 The Fenway, Boston, MA, 02115, USA. Department of Psychology, Northeastern University, Boston, MA, USA.Department of Psychology, Simmons College, 300 The Fenway, Boston, MA, 02115, USA.USDA-HNRCA, Neuroscience and Aging Lab, Boston, MA, USA.Department of Psychology, Simmons College, 300 The Fenway, Boston, MA, 02115, USA. amanda.carey@simmons.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29892789

Citation

Gildawie, Kelsea R., et al. "Protective Effects of Foods Containing Flavonoids On Age-Related Cognitive Decline." Current Nutrition Reports, vol. 7, no. 2, 2018, pp. 39-48.
Gildawie KR, Galli RL, Shukitt-Hale B, et al. Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline. Curr Nutr Rep. 2018;7(2):39-48.
Gildawie, K. R., Galli, R. L., Shukitt-Hale, B., & Carey, A. N. (2018). Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline. Current Nutrition Reports, 7(2), 39-48. https://doi.org/10.1007/s13668-018-0227-0
Gildawie KR, et al. Protective Effects of Foods Containing Flavonoids On Age-Related Cognitive Decline. Curr Nutr Rep. 2018;7(2):39-48. PubMed PMID: 29892789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline. AU - Gildawie,Kelsea R, AU - Galli,Rachel L, AU - Shukitt-Hale,Barbara, AU - Carey,Amanda N, PY - 2018/6/13/entrez PY - 2018/6/13/pubmed PY - 2019/7/19/medline KW - Aging KW - Brain KW - Cognition KW - Flavonoids KW - Neurodegeneration KW - Polyphenols SP - 39 EP - 48 JF - Current nutrition reports JO - Curr Nutr Rep VL - 7 IS - 2 N2 - PURPOSE OF REVIEW: Evidence suggests that flavonoids, polyphenolic compounds found in many plant-derived foods, such as berries, may allay cognitive impairment. We review recent research exploring the protective effects of flavonoids on age-related cognitive decline and neurodegenerative disorders in humans and animals. We also address the mechanisms by which flavonoids may exert their effects and promising avenues of future research. RECENT FINDINGS: Flavonoids have been found to decrease neuroinflammation, reduce oxidative stress, and mediate neuroplasticity in animal models of neurodegeneration and aging. Injecting flavonoids encased in metal nanoparticles may further enhance the efficacy of flavonoids. Animal studies also demonstrate that flavonoid supplementation may alleviate neurodegenerative cognitive and memory impairments. Limited human studies, however, demonstrate the need for further clinical research investigating flavonoids. Flavonoid supplementation, as well as dietary modification to include whole foods high in flavonoids, may provide therapeutic potential for aging individuals experiencing cognitive deficits resulting from neurodegeneration. SN - 2161-3311 UR - https://www.unboundmedicine.com/medline/citation/29892789/Protective_Effects_of_Foods_Containing_Flavonoids_on_Age_Related_Cognitive_Decline_ L2 - https://medlineplus.gov/degenerativenervediseases.html DB - PRIME DP - Unbound Medicine ER -