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Immunohistochemical evaluation of tumor angiogenesis and the role of mast cells in oral squamous cell carcinoma.
J Cancer Res Ther. 2018 Apr-Jun; 14(3):495-502.JC

Abstract

Background

Increased angiogenesis has been associated with neoplastic progression, metastasis and outcome in several studies and in a number of malignancies. Among the various host immune cells, mast cells have been implicated in tumor progression by promoting angiogenesis. The aim of this study is to examine the relationship between angiogenesis, mast cells with that of the normal oral mucosa (NOM) and oral squamous cell carcinoma (OSCC).

Materials and Methods

The study was conducted using routine haematoxylin and eosin staining procedure and included immunohistochemical staining for microvessels and toluidine blue staining for mast cells.

Results

The microvessel density (MVD) and mast cell density (MCD) of two groups (NOM and OSCC). The MVD and MCD in OSCC ranged from 59.18 to 263.31 microvessel/mm 2 and 41.65 to 193.28 cells/mm 2 respectively with mean (±standard deviation) 161.73 ± 48.27 microvessel/mm 2 and 83.59 ± 40.67 cells/mm 2. In both NOM and OSCC, the mean MCD was comparatively lower as compared to respective MVD (MCD < MVD) and comparatively lower in NOM as compared to OSCC (normal < OSCC).

Conclusion

A significant correlation is present between MCD and MVD in OSCC and also that both these entities are significantly increased in the disease process when compared to that of the NOM.

Authors+Show Affiliations

Department of Oral Pathology and Microbiology, Haldia Institute of Dental Sciences and Research, Purba Medinipur, Haldia, West Bengal, India.Department of Oral Pathology and Microbiology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.Department of Oral Pathology and Microbiology, Saraswati Dental College and Hospital, Lucknow, Uttar Pradesh, India.Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.Department of Oral Pathology and Microbiology, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.Department of Oral Pathology and Microbiology, King's George Medical University, Lucknow, Uttar Pradesh, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29893305

Citation

Kabiraj, Arpita, et al. "Immunohistochemical Evaluation of Tumor Angiogenesis and the Role of Mast Cells in Oral Squamous Cell Carcinoma." Journal of Cancer Research and Therapeutics, vol. 14, no. 3, 2018, pp. 495-502.
Kabiraj A, Jaiswal R, Singh A, et al. Immunohistochemical evaluation of tumor angiogenesis and the role of mast cells in oral squamous cell carcinoma. J Cancer Res Ther. 2018;14(3):495-502.
Kabiraj, A., Jaiswal, R., Singh, A., Gupta, J., Singh, A., & Samadi, F. M. (2018). Immunohistochemical evaluation of tumor angiogenesis and the role of mast cells in oral squamous cell carcinoma. Journal of Cancer Research and Therapeutics, 14(3), 495-502. https://doi.org/10.4103/0973-1482.163693
Kabiraj A, et al. Immunohistochemical Evaluation of Tumor Angiogenesis and the Role of Mast Cells in Oral Squamous Cell Carcinoma. J Cancer Res Ther. 2018 Apr-Jun;14(3):495-502. PubMed PMID: 29893305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunohistochemical evaluation of tumor angiogenesis and the role of mast cells in oral squamous cell carcinoma. AU - Kabiraj,Arpita, AU - Jaiswal,Rohit, AU - Singh,Anil, AU - Gupta,Jagriti, AU - Singh,Arun, AU - Samadi,Fahad M, PY - 2018/6/13/entrez PY - 2018/6/13/pubmed PY - 2018/10/9/medline KW - Angiogenesis KW - mast cell density KW - mast cells KW - microvessel density KW - oral squamous cell carcinoma SP - 495 EP - 502 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 14 IS - 3 N2 - Background: Increased angiogenesis has been associated with neoplastic progression, metastasis and outcome in several studies and in a number of malignancies. Among the various host immune cells, mast cells have been implicated in tumor progression by promoting angiogenesis. The aim of this study is to examine the relationship between angiogenesis, mast cells with that of the normal oral mucosa (NOM) and oral squamous cell carcinoma (OSCC). Materials and Methods: The study was conducted using routine haematoxylin and eosin staining procedure and included immunohistochemical staining for microvessels and toluidine blue staining for mast cells. Results: The microvessel density (MVD) and mast cell density (MCD) of two groups (NOM and OSCC). The MVD and MCD in OSCC ranged from 59.18 to 263.31 microvessel/mm 2 and 41.65 to 193.28 cells/mm 2 respectively with mean (±standard deviation) 161.73 ± 48.27 microvessel/mm 2 and 83.59 ± 40.67 cells/mm 2. In both NOM and OSCC, the mean MCD was comparatively lower as compared to respective MVD (MCD < MVD) and comparatively lower in NOM as compared to OSCC (normal < OSCC). Conclusion: A significant correlation is present between MCD and MVD in OSCC and also that both these entities are significantly increased in the disease process when compared to that of the NOM. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/29893305/Immunohistochemical_evaluation_of_tumor_angiogenesis_and_the_role_of_mast_cells_in_oral_squamous_cell_carcinoma_ L2 - http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2018;volume=14;issue=3;spage=495;epage=502;aulast=Kabiraj DB - PRIME DP - Unbound Medicine ER -