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Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium.
Cornea 2018; 37(10):1306-1310C

Abstract

PURPOSE

To investigate the possibility of an association between serum levels of zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe), copper (Cu), and selenium (Se) and advanced keratoconus (KCN).

METHODS

In this study, 50 patients with advanced KCN and 50 control subjects were included. Plasma levels of Zn, Ca, Mg, Fe, Cu, and Se were compared between the groups.

RESULTS

Mean ± SD age of the patients in the case and control groups was 29.3 ± 3.5 and 28.9 ± 5.9 years, respectively (P = 0.669). Among serum parameters, there were no statistically significant differences between the 2 groups in serum levels of Ca, Mg, and Fe (P > 0.05), whereas serum levels of Zn and Cu were significantly lower in the case group than the control group [65.92 ± 7.90 vs. 87.36 ± 13.64 μg/dL and 78.48 ± 11.96 vs. 116.34 ± 20.87 μg/dL, respectively (both P < 0.001)] as well as the serum level of Se [79.76 ± 19.16 vs. 87.41 ± 15.91 μg/dL (P = 0.032)].

CONCLUSIONS

The lower serum levels of Zn, Cu, and Se in patients with advanced KCN compared with healthy controls indicate the possible role of antioxidants in the etiopathogenesis of KCN, which points to early treatment of this progressive degenerative disease with supplementation therapy, rather than keratoplasty techniques.

Authors+Show Affiliations

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29894321

Citation

Bamdad, Shahram, et al. "Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium." Cornea, vol. 37, no. 10, 2018, pp. 1306-1310.
Bamdad S, Owji N, Bolkheir A. Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium. Cornea. 2018;37(10):1306-1310.
Bamdad, S., Owji, N., & Bolkheir, A. (2018). Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium. Cornea, 37(10), pp. 1306-1310. doi:10.1097/ICO.0000000000001661.
Bamdad S, Owji N, Bolkheir A. Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium. Cornea. 2018;37(10):1306-1310. PubMed PMID: 29894321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between Advanced Keratoconus and Serum Levels of Zinc, Calcium, Magnesium, Iron, Copper, and Selenium. AU - Bamdad,Shahram, AU - Owji,Naser, AU - Bolkheir,Alireza, PY - 2018/6/13/pubmed PY - 2018/10/26/medline PY - 2018/6/13/entrez SP - 1306 EP - 1310 JF - Cornea JO - Cornea VL - 37 IS - 10 N2 - PURPOSE: To investigate the possibility of an association between serum levels of zinc (Zn), calcium (Ca), magnesium (Mg), iron (Fe), copper (Cu), and selenium (Se) and advanced keratoconus (KCN). METHODS: In this study, 50 patients with advanced KCN and 50 control subjects were included. Plasma levels of Zn, Ca, Mg, Fe, Cu, and Se were compared between the groups. RESULTS: Mean ± SD age of the patients in the case and control groups was 29.3 ± 3.5 and 28.9 ± 5.9 years, respectively (P = 0.669). Among serum parameters, there were no statistically significant differences between the 2 groups in serum levels of Ca, Mg, and Fe (P > 0.05), whereas serum levels of Zn and Cu were significantly lower in the case group than the control group [65.92 ± 7.90 vs. 87.36 ± 13.64 μg/dL and 78.48 ± 11.96 vs. 116.34 ± 20.87 μg/dL, respectively (both P < 0.001)] as well as the serum level of Se [79.76 ± 19.16 vs. 87.41 ± 15.91 μg/dL (P = 0.032)]. CONCLUSIONS: The lower serum levels of Zn, Cu, and Se in patients with advanced KCN compared with healthy controls indicate the possible role of antioxidants in the etiopathogenesis of KCN, which points to early treatment of this progressive degenerative disease with supplementation therapy, rather than keratoplasty techniques. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/29894321/Association_Between_Advanced_Keratoconus_and_Serum_Levels_of_Zinc_Calcium_Magnesium_Iron_Copper_and_Selenium_ L2 - http://Insights.ovid.com/pubmed?pmid=29894321 DB - PRIME DP - Unbound Medicine ER -