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Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates.
J Eur Acad Dermatol Venereol. 2018 Jun; 32 Suppl 2:5-14.JE

Abstract

While the commensal bacterium Propionibacterium acnes (P. acnes) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on P. acnes shed light on the critical role of a tight equilibrium between members of its phylotypes and within the skin microbiota in the development of this skin disease. Indeed, contrary to what was previously thought, proliferation of P. acnes is not the trigger of acne as patients with acne do not harbour more P. acnes in follicles than normal individuals. Instead, the loss of the skin microbial diversity together with the activation of the innate immunity might lead to this chronic inflammatory condition. This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes (C. acnes), and to the better characterisation of its phylogenetic cluster groups. Moreover, the latest data on the role of C. acnes and its different phylotypes in acne are presented, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne-associated strains. Overall, this emerging key information offers new perspectives in the treatment of acne, with future innovative strategies focusing on C. acnes biofilms and/or on its acne-associated phylotypes.

Authors+Show Affiliations

Department of Dermatology, CIC 1413, CRCINA Inserm 1232, CHU Nantes, Nantes, France.Laboratoire de Génie Chimique, UMR 5503, Faculty of Pharmacy, Université de Toulouse, Université Paul Sabatier, Toulouse Cedex 9, France. CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, France.Department of Bacteriology, CRCINA Inserm 1232, CHU Nantes, Nantes, France.Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.Department of Dermatology, CIC 1413, CRCINA Inserm 1232, CHU Nantes, Nantes, France.Laboratoire de Génie Chimique, UMR 5503, Faculty of Pharmacy, Université de Toulouse, Université Paul Sabatier, Toulouse Cedex 9, France. CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29894579

Citation

Dréno, B, et al. "Cutibacterium Acnes (Propionibacterium Acnes) and Acne Vulgaris: a Brief Look at the Latest Updates." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 32 Suppl 2, 2018, pp. 5-14.
Dréno B, Pécastaings S, Corvec S, et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018;32 Suppl 2:5-14.
Dréno, B., Pécastaings, S., Corvec, S., Veraldi, S., Khammari, A., & Roques, C. (2018). Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. Journal of the European Academy of Dermatology and Venereology : JEADV, 32 Suppl 2, 5-14. https://doi.org/10.1111/jdv.15043
Dréno B, et al. Cutibacterium Acnes (Propionibacterium Acnes) and Acne Vulgaris: a Brief Look at the Latest Updates. J Eur Acad Dermatol Venereol. 2018;32 Suppl 2:5-14. PubMed PMID: 29894579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. AU - Dréno,B, AU - Pécastaings,S, AU - Corvec,S, AU - Veraldi,S, AU - Khammari,A, AU - Roques,C, PY - 2018/01/16/received PY - 2018/03/06/accepted PY - 2018/6/13/entrez PY - 2018/6/13/pubmed PY - 2018/10/31/medline SP - 5 EP - 14 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 32 Suppl 2 N2 - While the commensal bacterium Propionibacterium acnes (P. acnes) is involved in the maintenance of a healthy skin, it can also act as an opportunistic pathogen in acne vulgaris. The latest findings on P. acnes shed light on the critical role of a tight equilibrium between members of its phylotypes and within the skin microbiota in the development of this skin disease. Indeed, contrary to what was previously thought, proliferation of P. acnes is not the trigger of acne as patients with acne do not harbour more P. acnes in follicles than normal individuals. Instead, the loss of the skin microbial diversity together with the activation of the innate immunity might lead to this chronic inflammatory condition. This review provides results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes (C. acnes), and to the better characterisation of its phylogenetic cluster groups. Moreover, the latest data on the role of C. acnes and its different phylotypes in acne are presented, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne-associated strains. Overall, this emerging key information offers new perspectives in the treatment of acne, with future innovative strategies focusing on C. acnes biofilms and/or on its acne-associated phylotypes. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/29894579/Cutibacterium_acnes__Propionibacterium_acnes__and_acne_vulgaris:_a_brief_look_at_the_latest_updates_ L2 - https://doi.org/10.1111/jdv.15043 DB - PRIME DP - Unbound Medicine ER -