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Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus.
Psychother Psychosom. 2018; 87(4):204-210.PP

Abstract

BACKGROUND

Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice.

METHODS

A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated.

RESULTS

There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects.

CONCLUSIONS

The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice.

Authors+Show Affiliations

Health, Medical and Neuropsychology Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands.Departments of Pain Translational Symptoms Science and Anaesthesiology, School of Nursing and Medicine, University of Maryland Baltimore, Baltimore, Maryland, USA.General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.Institute of Biomedical Technologies, National Research Council, Rome, Italy.Section on Affective Neuroscience and Pain, NIH, Bethesda, Massachusetts, USA.Physiology and Neuroscience, University of Turin Medical School, Turin, Italy.Department of Neurology, University Hospital Essen, Essen, Germany.Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Department of Clinical and Health Psychology, Instituto Universitário de Ciências Psicológicas, Lisbon, Portugal.School of Psychology, University of Sydney, Sydney, New South Wales, Australia.Department of Psychology, Stanford University, Stanford, California, USA.Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.Faculty of Psychology, University of Basel, Basel, Switzerland.Department of Psychology, University of Toledo, Toledo, Ohio, USA.Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.Beth Israel Deaconess Medical Center, Program in Placebo Studies, Boston, Massachusetts, USA.Division of Health Promotion, University of Applied Sciences, Coburg, Germany.Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA.Health, Medical and Neuropsychology Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands.Departments of Psychiatry, Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada.Department of Clinical Psychology and Psychotherapy, Philipps University of Marburg, Marburg, Germany.Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado, USA.Department of Counseling Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA. Modum Bad Psychiatric Center, Vikersund, Norway.Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Ulm, Ulm, Germany.Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.Beth Israel Deaconess Medical Center, Program in Placebo Studies, Boston, Massachusetts, USA.Center for Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.Beth Israel Deaconess Medical Center, Program in Placebo Studies, Boston, Massachusetts, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29895014

Citation

Evers, Andrea W M., et al. "Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus." Psychotherapy and Psychosomatics, vol. 87, no. 4, 2018, pp. 204-210.
Evers AWM, Colloca L, Blease C, et al. Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. Psychother Psychosom. 2018;87(4):204-210.
Evers, A. W. M., Colloca, L., Blease, C., Annoni, M., Atlas, L. Y., Benedetti, F., Bingel, U., Büchel, C., Carvalho, C., Colagiuri, B., Crum, A. J., Enck, P., Gaab, J., Geers, A. L., Howick, J., Jensen, K. B., Kirsch, I., Meissner, K., Napadow, V., ... Kelley, J. M. (2018). Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. Psychotherapy and Psychosomatics, 87(4), 204-210. https://doi.org/10.1159/000490354
Evers AWM, et al. Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. Psychother Psychosom. 2018;87(4):204-210. PubMed PMID: 29895014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. AU - Evers,Andrea W M, AU - Colloca,Luana, AU - Blease,Charlotte, AU - Annoni,Marco, AU - Atlas,Lauren Y, AU - Benedetti,Fabrizio, AU - Bingel,Ulrike, AU - Büchel,Christian, AU - Carvalho,Claudia, AU - Colagiuri,Ben, AU - Crum,Alia J, AU - Enck,Paul, AU - Gaab,Jens, AU - Geers,Andrew L, AU - Howick,Jeremy, AU - Jensen,Karin B, AU - Kirsch,Irving, AU - Meissner,Karin, AU - Napadow,Vitaly, AU - Peerdeman,Kaya J, AU - Raz,Amir, AU - Rief,Winfried, AU - Vase,Lene, AU - Wager,Tor D, AU - Wampold,Bruce E, AU - Weimer,Katja, AU - Wiech,Katja, AU - Kaptchuk,Ted J, AU - Klinger,Regine, AU - Kelley,John M, Y1 - 2018/06/12/ PY - 2018/03/14/received PY - 2018/05/22/accepted PY - 2018/6/13/pubmed PY - 2018/11/6/medline PY - 2018/6/13/entrez KW - Clinical practice KW - Evidence-based ethical recommendations KW - Nocebo effect KW - Patient-clinician communication KW - Patient’s expectancies KW - Placebo effect SP - 204 EP - 210 JF - Psychotherapy and psychosomatics JO - Psychother Psychosom VL - 87 IS - 4 N2 - BACKGROUND: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice. METHODS: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated. RESULTS: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects. CONCLUSIONS: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice. SN - 1423-0348 UR - https://www.unboundmedicine.com/medline/citation/29895014/Implications_of_Placebo_and_Nocebo_Effects_for_Clinical_Practice:_Expert_Consensus_ L2 - https://www.karger.com?DOI=10.1159/000490354 DB - PRIME DP - Unbound Medicine ER -