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Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri.
Phytomedicine 2018; 44:1-8P

Abstract

BACKGROUND

Vinegar baked Radix Bupleuri (VBRB) is a wildly used traditional Chinese medicine, it could be used as a meridian guided drug to enhance liver targeting efficiency of the delivered drug in addition to its therapeutic effect.

PURPOSE

To investigate the liver targeting effect induced by VBRB via coadministration with 10-Hydroxycamptothecin loaded polymeric micelles.

METHODS

First of all, the inhibitory effect of VBRB on the activity of glutathione S-transferase (GST) was investigated in vitro to select the most effective extract. After oral administration of 10-Hydroxycamptothecin (HCPT) polymeric micelles with low, medium and high doses of VBRB, pharmacokinetic parameters, including the ratio of Cmax in the liver (Ce) and the relative uptake efficiency (RUE), were employed to assess the liver targeting efficiency.

RESULTS

It was found that VBRB extract BC1 has the strongest inhibition effect on GST activity in the five extracts. By coadministration of HCPT loaded micelles with three doses of BC1, the AUC0-t of HCPT in the liver raised by 42.5%, 23.0%, -0.2%, with RUE 1.45, 1.23, 1.02 for low, medium and high dose groups, respectively, indicating that low and medium dose of BC1 presented better liver-targeting enhancing effect than that of the high dose, which corresponded to the commonly used dose of VBRB in traditional Chinese medicine formulae.

CONCLUSIONS

VBRB could effectively enhance the liver-targeting efficiency of HCPT loaded polymeric micelles after oral coadministration. Such a simple but effective strategy may enlighten on the potential use of meridian guided drug together with modern drug delivery system to achieve better active drug targeting.

Authors+Show Affiliations

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Daxuecheng, Guangzhou, China.Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Daxuecheng, Guangzhou, China. Electronic address: 13610241754@163.com.School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: maoshirui@syphu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29895488

Citation

Wu, Haiyang, et al. "Enhanced Liver-targeting Via Coadministration of 10-Hydroxycamptothecin Polymeric Micelles With Vinegar Baked Radix Bupleuri." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 44, 2018, pp. 1-8.
Wu H, Yu T, Tian Y, et al. Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri. Phytomedicine. 2018;44:1-8.
Wu, H., Yu, T., Tian, Y., Wang, Y., Zhao, R., & Mao, S. (2018). Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 44, pp. 1-8. doi:10.1016/j.phymed.2018.04.022.
Wu H, et al. Enhanced Liver-targeting Via Coadministration of 10-Hydroxycamptothecin Polymeric Micelles With Vinegar Baked Radix Bupleuri. Phytomedicine. 2018 May 15;44:1-8. PubMed PMID: 29895488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri. AU - Wu,Haiyang, AU - Yu,Tongya, AU - Tian,Ye, AU - Wang,Yinjie, AU - Zhao,Ruizhi, AU - Mao,Shirui, Y1 - 2018/04/10/ PY - 2017/03/23/received PY - 2018/02/13/revised PY - 2018/04/08/accepted PY - 2018/6/14/entrez PY - 2018/6/14/pubmed PY - 2018/7/3/medline KW - Glutathione S-transferase (GST) KW - Liver-targeting KW - Meridian guided drug KW - Polymeric micelles KW - Vinegar baked Radix Bupleuri (VBRB) SP - 1 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 44 N2 - BACKGROUND: Vinegar baked Radix Bupleuri (VBRB) is a wildly used traditional Chinese medicine, it could be used as a meridian guided drug to enhance liver targeting efficiency of the delivered drug in addition to its therapeutic effect. PURPOSE: To investigate the liver targeting effect induced by VBRB via coadministration with 10-Hydroxycamptothecin loaded polymeric micelles. METHODS: First of all, the inhibitory effect of VBRB on the activity of glutathione S-transferase (GST) was investigated in vitro to select the most effective extract. After oral administration of 10-Hydroxycamptothecin (HCPT) polymeric micelles with low, medium and high doses of VBRB, pharmacokinetic parameters, including the ratio of Cmax in the liver (Ce) and the relative uptake efficiency (RUE), were employed to assess the liver targeting efficiency. RESULTS: It was found that VBRB extract BC1 has the strongest inhibition effect on GST activity in the five extracts. By coadministration of HCPT loaded micelles with three doses of BC1, the AUC0-t of HCPT in the liver raised by 42.5%, 23.0%, -0.2%, with RUE 1.45, 1.23, 1.02 for low, medium and high dose groups, respectively, indicating that low and medium dose of BC1 presented better liver-targeting enhancing effect than that of the high dose, which corresponded to the commonly used dose of VBRB in traditional Chinese medicine formulae. CONCLUSIONS: VBRB could effectively enhance the liver-targeting efficiency of HCPT loaded polymeric micelles after oral coadministration. Such a simple but effective strategy may enlighten on the potential use of meridian guided drug together with modern drug delivery system to achieve better active drug targeting. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/29895488/Enhanced_liver_targeting_via_coadministration_of_10_Hydroxycamptothecin_polymeric_micelles_with_vinegar_baked_Radix_Bupleuri_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(18)30122-3 DB - PRIME DP - Unbound Medicine ER -