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Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report.
J Int Med Res 2018; 46(8):3498-3503JI

Abstract

Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene (ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta (PDGFR-β), and ETS translocation variant (ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT. Ultrasonography and magnetic resonance imaging revealed a myxoid degenerative myoma-like mass, 7.4 cm in maximum diameter, on the left uterine side wall. Hysterectomy was performed as a definitive treatment. Microscopic examination revealed spindle cell proliferation with numerous lymphocytes and plasma cells. Immunohistochemically, the spindle cells were negative for ALK-1, desmin, and smooth muscle actin. The pathological diagnosis was IMT arising from the uterus. Fluorescence in situ hybridization demonstrated an ETV6-neurotrophic tyrosine kinase, receptor, type 3 gene (NTRK3) translocation but no ALK, ROS1, or PDGFR-β translocations. Lung and abdomen computed tomography at 31 months postoperatively revealed no disease recurrence. This association of an ETV6-NTRK3 fusion oncogene with an ALK-negative uterine IMT increases our understanding of this neoplasm, which may help the development of specific therapies.

Authors+Show Affiliations

1 Department of Obstetrics and Gynecology, Nagahama City Hospital, Shiga, Japan.2 Department of Pathology, Nagahama City Hospital, Shiga, Japan.1 Department of Obstetrics and Gynecology, Nagahama City Hospital, Shiga, Japan.1 Department of Obstetrics and Gynecology, Nagahama City Hospital, Shiga, Japan.1 Department of Obstetrics and Gynecology, Nagahama City Hospital, Shiga, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29900760

Citation

Takahashi, Akimasa, et al. "Anaplastic Lymphoma Kinase-negative Uterine Inflammatory Myofibroblastic Tumor Containing the ETV6-NTRK3 Fusion Gene: a Case Report." The Journal of International Medical Research, vol. 46, no. 8, 2018, pp. 3498-3503.
Takahashi A, Kurosawa M, Uemura M, et al. Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report. J Int Med Res. 2018;46(8):3498-3503.
Takahashi, A., Kurosawa, M., Uemura, M., Kitazawa, J., & Hayashi, Y. (2018). Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report. The Journal of International Medical Research, 46(8), pp. 3498-3503. doi:10.1177/0300060518780873.
Takahashi A, et al. Anaplastic Lymphoma Kinase-negative Uterine Inflammatory Myofibroblastic Tumor Containing the ETV6-NTRK3 Fusion Gene: a Case Report. J Int Med Res. 2018;46(8):3498-3503. PubMed PMID: 29900760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report. AU - Takahashi,Akimasa, AU - Kurosawa,Manabu, AU - Uemura,Mao, AU - Kitazawa,Jun, AU - Hayashi,Yoshihiko, Y1 - 2018/06/14/ PY - 2018/6/15/pubmed PY - 2019/1/24/medline PY - 2018/6/15/entrez KW - ETV6–NTRK3 fusion gene KW - Inflammatory myofibroblastic tumor KW - anaplastic lymphoma kinase KW - crizotinib KW - fluorescence in situ hybridization KW - uterus SP - 3498 EP - 3503 JF - The Journal of international medical research JO - J. Int. Med. Res. VL - 46 IS - 8 N2 - Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene (ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta (PDGFR-β), and ETS translocation variant (ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT. Ultrasonography and magnetic resonance imaging revealed a myxoid degenerative myoma-like mass, 7.4 cm in maximum diameter, on the left uterine side wall. Hysterectomy was performed as a definitive treatment. Microscopic examination revealed spindle cell proliferation with numerous lymphocytes and plasma cells. Immunohistochemically, the spindle cells were negative for ALK-1, desmin, and smooth muscle actin. The pathological diagnosis was IMT arising from the uterus. Fluorescence in situ hybridization demonstrated an ETV6-neurotrophic tyrosine kinase, receptor, type 3 gene (NTRK3) translocation but no ALK, ROS1, or PDGFR-β translocations. Lung and abdomen computed tomography at 31 months postoperatively revealed no disease recurrence. This association of an ETV6-NTRK3 fusion oncogene with an ALK-negative uterine IMT increases our understanding of this neoplasm, which may help the development of specific therapies. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/29900760/Anaplastic_lymphoma_kinase_negative_uterine_inflammatory_myofibroblastic_tumor_containing_the_ETV6_NTRK3_fusion_gene:_a_case_report_ L2 - http://journals.sagepub.com/doi/full/10.1177/0300060518780873?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -