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Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjögren syndrome patients: A case-control study.
Medicine (Baltimore). 2018 Jun; 97(24):e11003.M

Abstract

To determine the prevalence of pulmonary complications in primary Sjögren syndrome (pSS), and to identify the risk factors and the prognosis associated with pulmonary involvement in pSS patients.A total of 1341 hospitalized patients (853 with pSS and 488 with secondary Sjögren syndrome [sSS]) were retrospectively reviewed. Of these, 165 hospitalized patients with pSS-associated interstitial lung disease (ILD) were analyzed and recruited as a study group. Eighty-four pSS patients without organ damage were included as a control group.One hundred and sixty-five patients (19.34%) from the pSS group and 126 patients (25.82%) from the sSS group presented with lung involvement. Of the 165 pSS patients with lung complications, 151 (91.5%) were women. The mean age was 61.25 ± 9.79 years, and the median disease duration was 84 (24-156) months. Non-specific interstitial pneumonia (NSIP; 39.1%) was the predominant pattern on high-resolution computed tomography (HRCT). The total HRCT score was 9.71 ± 4.77. Impairment in diffusion capacity was the most common (74.3%) and severe complication (predicted value of TLCO was 57.5 ± 21.2%). The 5-year survival rate for all patients with pSS-ILD was 88.5%. Age, disease duration, rheumatoid factor (RF), and C-reactive protein (CRP) were significantly higher than in controls, whereas anti-SSA was less common. Age, RF, and CRP were independent predictors of ILD after adjustment for confounders.Lung involvement is a common and severe complication of Sjögren syndrome. Age and disease activity are correlated with pulmonary involvement in pSS patients.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Peking University People's Hospital Department of Rheumatology and Immunology Department of Radiology, Peking University International Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

29901591

Citation

Gao, Hui, et al. "Prevalence, Risk Factors, and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren Syndrome Patients: a Case-control Study." Medicine, vol. 97, no. 24, 2018, pp. e11003.
Gao H, Zhang XW, He J, et al. Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjögren syndrome patients: A case-control study. Medicine (Baltimore). 2018;97(24):e11003.
Gao, H., Zhang, X. W., He, J., Zhang, J., An, Y., Sun, Y., Jia, R. L., Li, S. G., Zhang, L. J., & Li, Z. G. (2018). Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjögren syndrome patients: A case-control study. Medicine, 97(24), e11003. https://doi.org/10.1097/MD.0000000000011003
Gao H, et al. Prevalence, Risk Factors, and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren Syndrome Patients: a Case-control Study. Medicine (Baltimore). 2018;97(24):e11003. PubMed PMID: 29901591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence, risk factors, and prognosis of interstitial lung disease in a large cohort of Chinese primary Sjögren syndrome patients: A case-control study. AU - Gao,Hui, AU - Zhang,Xue-Wu, AU - He,Jing, AU - Zhang,Jing, AU - An,Yuan, AU - Sun,Ye, AU - Jia,Ru-Lin, AU - Li,Sheng-Guang, AU - Zhang,Li-Jing, AU - Li,Zhan-Guo, PY - 2018/6/15/entrez PY - 2018/6/15/pubmed PY - 2018/6/27/medline SP - e11003 EP - e11003 JF - Medicine JO - Medicine (Baltimore) VL - 97 IS - 24 N2 - To determine the prevalence of pulmonary complications in primary Sjögren syndrome (pSS), and to identify the risk factors and the prognosis associated with pulmonary involvement in pSS patients.A total of 1341 hospitalized patients (853 with pSS and 488 with secondary Sjögren syndrome [sSS]) were retrospectively reviewed. Of these, 165 hospitalized patients with pSS-associated interstitial lung disease (ILD) were analyzed and recruited as a study group. Eighty-four pSS patients without organ damage were included as a control group.One hundred and sixty-five patients (19.34%) from the pSS group and 126 patients (25.82%) from the sSS group presented with lung involvement. Of the 165 pSS patients with lung complications, 151 (91.5%) were women. The mean age was 61.25 ± 9.79 years, and the median disease duration was 84 (24-156) months. Non-specific interstitial pneumonia (NSIP; 39.1%) was the predominant pattern on high-resolution computed tomography (HRCT). The total HRCT score was 9.71 ± 4.77. Impairment in diffusion capacity was the most common (74.3%) and severe complication (predicted value of TLCO was 57.5 ± 21.2%). The 5-year survival rate for all patients with pSS-ILD was 88.5%. Age, disease duration, rheumatoid factor (RF), and C-reactive protein (CRP) were significantly higher than in controls, whereas anti-SSA was less common. Age, RF, and CRP were independent predictors of ILD after adjustment for confounders.Lung involvement is a common and severe complication of Sjögren syndrome. Age and disease activity are correlated with pulmonary involvement in pSS patients. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/29901591/Prevalence_risk_factors_and_prognosis_of_interstitial_lung_disease_in_a_large_cohort_of_Chinese_primary_Sjögren_syndrome_patients:_A_case_control_study_ L2 - https://doi.org/10.1097/MD.0000000000011003 DB - PRIME DP - Unbound Medicine ER -