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Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota.

Abstract

BACKGROUND/OBJECTIVES

Folate, vitamin B6, vitamin B12, and methionine are involved in DNA synthesis and methylation and thus may modulate pancreatic cancer risk. We investigated these associations in a population-based case-control study conducted in 1994-1998.

SUBJECTS/METHODS

Cases (n = 150) were identified from all hospitals in the metropolitan areas of the Twin Cities and the Mayo Clinic, Minnesota. Controls (n = 459) were selected randomly from the general population and were frequency matched to cases by age, sex, and race. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for risk of pancreatic cancer in relation to intake of nutrients considered.

RESULTS

Dietary intake of folate was associated with a reduced pancreatic cancer risk [OR (95% CI) for quartile (Q) 4 vs. Q1: 0.31 (0.12-0.78)]. A composite score (range from 2 to 8), reflecting combined dietary intake of folate and vitamin B6, was also inversely associated with pancreatic cancer risk [OR (95% CI) for Q4 vs. Q1: 0.24 (0.08-0.70)]. Null associations were found for intake of vitamin B12 and methionine.

CONCLUSIONS

Dietary folate intake was associated with a reduced pancreatic cancer risk, and this association became stronger when dietary intake of folate and vitamin B6 was combined in analysis.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, 1050 Wishard Boulevard, IN, 46202, USA.

    ,

    Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, 1050 Wishard Boulevard, IN, 46202, USA.

    ,

    Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, 1050 Wishard Boulevard, IN, 46202, USA.

    ,

    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 420 Delaware Avenue SE, Minneapolis, MN, 55455, USA. Masonic Cancer Center, University of Minnesota, 425 East River Road, Minneapolis, MN, 55455, USA.

    Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, 1050 Wishard Boulevard, IN, 46202, USA. JZ21@iu.edu. Indiana University Melvin and Bren Simon Cancer Center, 535 Barnhill Drive, Indianapolis, IN, 46202, USA. JZ21@iu.edu.

    Source

    European journal of clinical nutrition 72:8 2018 08 pg 1128-1135

    MeSH

    Adult
    Aged
    Case-Control Studies
    DNA Methylation
    Diet
    Dietary Supplements
    Female
    Folic Acid
    Humans
    Male
    Methionine
    Middle Aged
    Minnesota
    Odds Ratio
    Pancreatic Neoplasms
    Risk Factors
    Vitamin B 12
    Vitamin B 6

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    29904184

    Citation

    Marley, Andrew R., et al. "Intake of Methyl-related Nutrients and Risk of Pancreatic Cancer in a Population-based Case-control Study in Minnesota." European Journal of Clinical Nutrition, vol. 72, no. 8, 2018, pp. 1128-1135.
    Marley AR, Fan H, Hoyt ML, et al. Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota. Eur J Clin Nutr. 2018;72(8):1128-1135.
    Marley, A. R., Fan, H., Hoyt, M. L., Anderson, K. E., & Zhang, J. (2018). Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota. European Journal of Clinical Nutrition, 72(8), pp. 1128-1135. doi:10.1038/s41430-018-0228-5.
    Marley AR, et al. Intake of Methyl-related Nutrients and Risk of Pancreatic Cancer in a Population-based Case-control Study in Minnesota. Eur J Clin Nutr. 2018;72(8):1128-1135. PubMed PMID: 29904184.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of methyl-related nutrients and risk of pancreatic cancer in a population-based case-control study in Minnesota. AU - Marley,Andrew R, AU - Fan,Hao, AU - Hoyt,Margaret L, AU - Anderson,Kristin E, AU - Zhang,Jianjun, Y1 - 2018/06/14/ PY - 2018/03/02/received PY - 2018/05/22/accepted PY - 2018/05/17/revised PY - 2018/6/16/pubmed PY - 2019/5/14/medline PY - 2018/6/16/entrez SP - 1128 EP - 1135 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 72 IS - 8 N2 - BACKGROUND/OBJECTIVES: Folate, vitamin B6, vitamin B12, and methionine are involved in DNA synthesis and methylation and thus may modulate pancreatic cancer risk. We investigated these associations in a population-based case-control study conducted in 1994-1998. SUBJECTS/METHODS: Cases (n = 150) were identified from all hospitals in the metropolitan areas of the Twin Cities and the Mayo Clinic, Minnesota. Controls (n = 459) were selected randomly from the general population and were frequency matched to cases by age, sex, and race. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for risk of pancreatic cancer in relation to intake of nutrients considered. RESULTS: Dietary intake of folate was associated with a reduced pancreatic cancer risk [OR (95% CI) for quartile (Q) 4 vs. Q1: 0.31 (0.12-0.78)]. A composite score (range from 2 to 8), reflecting combined dietary intake of folate and vitamin B6, was also inversely associated with pancreatic cancer risk [OR (95% CI) for Q4 vs. Q1: 0.24 (0.08-0.70)]. Null associations were found for intake of vitamin B12 and methionine. CONCLUSIONS: Dietary folate intake was associated with a reduced pancreatic cancer risk, and this association became stronger when dietary intake of folate and vitamin B6 was combined in analysis. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/29904184/Intake_of_methyl_related_nutrients_and_risk_of_pancreatic_cancer_in_a_population_based_case_control_study_in_Minnesota_ L2 - http://dx.doi.org/10.1038/s41430-018-0228-5 DB - PRIME DP - Unbound Medicine ER -