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Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways.
Int Immunopharmacol. 2018 Aug; 61:277-282.II

Abstract

Cisplatin is a chemotherapeutic agent that widely used in the treatment of cancer. However, cisplatin has been reported to induce nephrotoxicity by directly inducing inflammatory response and oxidative stress. In this study, we aimed to investigate the protective effects and mechanism of xanthohumol on cisplatin-induced nephrotoxicity. The model of nephrotoxicity was induced by intraperitoneal injection of cisplatin and xanthohumol was given intraperitoneally for three consecutive days. The results showed that xanthohumol significantly attenuated kidney histological changes and serum creatinine and BUN production. The levels of TNF-α, IL-1β and IL-6 in kidney tissues were suppressed by xanthohumol. The levels of malondialdehyde (MDA) and ROS were suppressed by treatment of xanthohumol. The activities of glutathione (GSH) and superoxide dismutase (SOD) decreased by cisplatin were reversed by xanthohumol. Furthermore, the expression of TLR4 and the activation of NF-κB induced by cisplatin were significantly inhibited by xanthohumol. The expression of Nrf2 and HO-1 were dose-dependently up-regulated by the treatment of xanthohumol. In conclusion, xanthohumol protects against cisplatin-induced nephrotoxicity by ameliorating inflammatory and oxidative responses.

Authors+Show Affiliations

Department of International Medical Center, the Chinese PLA General Hospital, Beijing 100853, China.Department of Medical Technology and Key Laboratory of Biotechnology for Laboratory Medicine of Suzhou, Suzhou Vocational Health College, Suzhou, Jiangsu 215009, China.Department of International Medical Center, the Chinese PLA General Hospital, Beijing 100853, China.Department of International Medical Center, the Chinese PLA General Hospital, Beijing 100853, China.Department of International Medical Center, the Chinese PLA General Hospital, Beijing 100853, China. Electronic address: yingmingzhong33@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29906742

Citation

Li, Fan, et al. "Xanthohumol Attenuates Cisplatin-induced Nephrotoxicity Through Inhibiting NF-κB and Activating Nrf2 Signaling Pathways." International Immunopharmacology, vol. 61, 2018, pp. 277-282.
Li F, Yao Y, Huang H, et al. Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways. Int Immunopharmacol. 2018;61:277-282.
Li, F., Yao, Y., Huang, H., Hao, H., & Ying, M. (2018). Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways. International Immunopharmacology, 61, 277-282. https://doi.org/10.1016/j.intimp.2018.05.017
Li F, et al. Xanthohumol Attenuates Cisplatin-induced Nephrotoxicity Through Inhibiting NF-κB and Activating Nrf2 Signaling Pathways. Int Immunopharmacol. 2018;61:277-282. PubMed PMID: 29906742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthohumol attenuates cisplatin-induced nephrotoxicity through inhibiting NF-κB and activating Nrf2 signaling pathways. AU - Li,Fan, AU - Yao,Yunyi, AU - Huang,Hui, AU - Hao,Hua, AU - Ying,Mingzhong, Y1 - 2018/06/12/ PY - 2018/03/30/received PY - 2018/05/09/revised PY - 2018/05/22/accepted PY - 2018/6/16/pubmed PY - 2018/11/9/medline PY - 2018/6/16/entrez KW - Cisplatin KW - Nephrotoxicity KW - Nrf2 KW - Xanthohumol SP - 277 EP - 282 JF - International immunopharmacology JO - Int Immunopharmacol VL - 61 N2 - Cisplatin is a chemotherapeutic agent that widely used in the treatment of cancer. However, cisplatin has been reported to induce nephrotoxicity by directly inducing inflammatory response and oxidative stress. In this study, we aimed to investigate the protective effects and mechanism of xanthohumol on cisplatin-induced nephrotoxicity. The model of nephrotoxicity was induced by intraperitoneal injection of cisplatin and xanthohumol was given intraperitoneally for three consecutive days. The results showed that xanthohumol significantly attenuated kidney histological changes and serum creatinine and BUN production. The levels of TNF-α, IL-1β and IL-6 in kidney tissues were suppressed by xanthohumol. The levels of malondialdehyde (MDA) and ROS were suppressed by treatment of xanthohumol. The activities of glutathione (GSH) and superoxide dismutase (SOD) decreased by cisplatin were reversed by xanthohumol. Furthermore, the expression of TLR4 and the activation of NF-κB induced by cisplatin were significantly inhibited by xanthohumol. The expression of Nrf2 and HO-1 were dose-dependently up-regulated by the treatment of xanthohumol. In conclusion, xanthohumol protects against cisplatin-induced nephrotoxicity by ameliorating inflammatory and oxidative responses. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/29906742/Xanthohumol_attenuates_cisplatin_induced_nephrotoxicity_through_inhibiting_NF_κB_and_activating_Nrf2_signaling_pathways_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(18)30228-5 DB - PRIME DP - Unbound Medicine ER -