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Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study.
Fertil Steril. 2018 07 01; 110(1):35-44.FS

Abstract

OBJECTIVE

To study the association between maternal diabetes and timing of pubertal development in daughters and sons.

DESIGN

Prospective cohort study.

SETTING

Not applicable.

PATIENT(S)

A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Adjusted mean monthly difference in age at attaining pubertal milestones in children born of mothers with diabetes compared with children born of mothers without diabetes.

RESULT(S)

A total of 502 children were born of mothers with diabetes during pregnancy. In daughters exposed to gestational diabetes mellitus, we observed advanced onset in all pubertal milestones. The associations were statistically significant with regard to pubic hair Tanner stage 2 (-4.8 months) (95% confidence interval [CI] -7.7, -2.0), pubic hair Tanner stage 3 (-2.2 months) (95 % CI -4.4, 0.0), pubic hair Tanner stage 5 (-6.0 months) (95% CI -10.8, -1.2), and menarche (-2.5 months) (95 % CI -4.9, 0.0). We observed no tendencies between maternal type 1 or type 2 diabetes mellitus and pubertal development in daughters. We observed no associations between maternal diabetes and pubertal development in sons.

CONCLUSION(S)

Our findings suggest that gestational diabetes mellitus may accelerate the pubertal development in daughters. Our results did not support an association between type 1 or type 2 diabetes mellitus and daughters' pubertal development, as well as between any type of maternal diabetes and sons' pubertal development.

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Authors+Show Affiliations

Lauridsen LLB
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. Electronic address: llbl@ph.au.dk.
Arendt LH
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Ernst A
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Brix N
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Parner ET
Department of Public Health, Section for Biostatistics, Aarhus University, Aarhus, Denmark.
Olsen J
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Ramlau-Hansen CH
Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.

MeSH

AdolescentAdultChildCohort StudiesDenmarkDiabetes, GestationalFemaleHumansInfant, NewbornMenarcheNuclear FamilyPregnancyPrenatal Exposure Delayed EffectsPubertySexual MaturationTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29908773

Citation

Lauridsen, Lea L B., et al. "Maternal Diabetes Mellitus and Timing of Pubertal Development in Daughters and Sons: a Nationwide Cohort Study." Fertility and Sterility, vol. 110, no. 1, 2018, pp. 35-44.
Lauridsen LLB, Arendt LH, Ernst A, et al. Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study. Fertil Steril. 2018;110(1):35-44.
Lauridsen, L. L. B., Arendt, L. H., Ernst, A., Brix, N., Parner, E. T., Olsen, J., & Ramlau-Hansen, C. H. (2018). Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study. Fertility and Sterility, 110(1), 35-44. https://doi.org/10.1016/j.fertnstert.2018.03.014
Lauridsen LLB, et al. Maternal Diabetes Mellitus and Timing of Pubertal Development in Daughters and Sons: a Nationwide Cohort Study. Fertil Steril. 2018 07 1;110(1):35-44. PubMed PMID: 29908773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal diabetes mellitus and timing of pubertal development in daughters and sons: a nationwide cohort study. AU - Lauridsen,Lea L B, AU - Arendt,Linn H, AU - Ernst,Andreas, AU - Brix,Nis, AU - Parner,Erik T, AU - Olsen,Jørn, AU - Ramlau-Hansen,Cecilia H, Y1 - 2018/06/13/ PY - 2017/12/21/received PY - 2018/03/11/revised PY - 2018/03/12/accepted PY - 2018/6/18/pubmed PY - 2019/1/29/medline PY - 2018/6/18/entrez KW - Puberty KW - Tanner stages KW - diabetes mellitus KW - gestational KW - prenatal exposure SP - 35 EP - 44 JF - Fertility and sterility JO - Fertil Steril VL - 110 IS - 1 N2 - OBJECTIVE: To study the association between maternal diabetes and timing of pubertal development in daughters and sons. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): A total of 15,822 mother-child pairs included in the Danish National Birth Cohort and the Puberty Cohort with prospectively collected, register-based and self-reported information on maternal diabetes and self-reported information on pubertal development. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Adjusted mean monthly difference in age at attaining pubertal milestones in children born of mothers with diabetes compared with children born of mothers without diabetes. RESULT(S): A total of 502 children were born of mothers with diabetes during pregnancy. In daughters exposed to gestational diabetes mellitus, we observed advanced onset in all pubertal milestones. The associations were statistically significant with regard to pubic hair Tanner stage 2 (-4.8 months) (95% confidence interval [CI] -7.7, -2.0), pubic hair Tanner stage 3 (-2.2 months) (95 % CI -4.4, 0.0), pubic hair Tanner stage 5 (-6.0 months) (95% CI -10.8, -1.2), and menarche (-2.5 months) (95 % CI -4.9, 0.0). We observed no tendencies between maternal type 1 or type 2 diabetes mellitus and pubertal development in daughters. We observed no associations between maternal diabetes and pubertal development in sons. CONCLUSION(S): Our findings suggest that gestational diabetes mellitus may accelerate the pubertal development in daughters. Our results did not support an association between type 1 or type 2 diabetes mellitus and daughters' pubertal development, as well as between any type of maternal diabetes and sons' pubertal development. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/29908773/Maternal_diabetes_mellitus_and_timing_of_pubertal_development_in_daughters_and_sons:_a_nationwide_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(18)30267-X DB - PRIME DP - Unbound Medicine ER -