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Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematode Caenorhabditis elegans.
Ecotoxicol Environ Saf. 2018 10; 161:444-450.EE

Abstract

The possible adverse effects of nanoplastics have received the great attention recently; however, their effects at environmentally relevant concentration on organisms are still largely unclear. We here employed Caenorhabditis elegans to investigate the combinational effects of titanium dioxide nanoparticles (TiO2-NPs) and nanopolystyrene particles at environmentally relevant concentrations on organisms. In wild-type nematodes, prolonged exposure to nanopolystyrene particles (1 μg/L) could enhance the toxicity of TiO2-NPs (1 μg/L) in decreasing locomotion behavior and in inducing intestinal reactive oxygen species (ROS) production. Meanwhile, combinational exposure to TiO2-NPs (1 μg/L) and nanopolystyrene particles (1 μg/L) altered the molecular basis for oxidative stress in wild-type nematodes. Moreover, prolonged exposure to nanopolystyrene particles (0.1 μg/L) could further enhance the toxicity of TiO2-NPs (1 μg/L) in decreasing locomotion behavior and in inducing intestinal ROS production in sod-3 mutant nematodes. Our data suggest the potential role of nanopolystyrene particles at environmentally relevant concentrations in enhancing the toxicity of ENMs in the environment.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Dong S
College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China; Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing 210009, China.
Qu M
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing 210009, China.
Rui Q
College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China. Electronic address: ruiqi@njau.edu.cn.
Wang D
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing 210009, China. Electronic address: dayongw@seu.edu.cn.

MeSH

AnimalsCaenorhabditis elegansClutch SizeDrug InteractionsIntestinesLocomotionNanoparticlesOxidative StressPolystyrenesReactive Oxygen SpeciesTitanium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29909313

Citation

Dong, Shuangshuang, et al. "Combinational Effect of Titanium Dioxide Nanoparticles and Nanopolystyrene Particles at Environmentally Relevant Concentrations On Nematode Caenorhabditis Elegans." Ecotoxicology and Environmental Safety, vol. 161, 2018, pp. 444-450.
Dong S, Qu M, Rui Q, et al. Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematode Caenorhabditis elegans. Ecotoxicol Environ Saf. 2018;161:444-450.
Dong, S., Qu, M., Rui, Q., & Wang, D. (2018). Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematode Caenorhabditis elegans. Ecotoxicology and Environmental Safety, 161, 444-450. https://doi.org/10.1016/j.ecoenv.2018.06.021
Dong S, et al. Combinational Effect of Titanium Dioxide Nanoparticles and Nanopolystyrene Particles at Environmentally Relevant Concentrations On Nematode Caenorhabditis Elegans. Ecotoxicol Environ Saf. 2018;161:444-450. PubMed PMID: 29909313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combinational effect of titanium dioxide nanoparticles and nanopolystyrene particles at environmentally relevant concentrations on nematode Caenorhabditis elegans. AU - Dong,Shuangshuang, AU - Qu,Man, AU - Rui,Qi, AU - Wang,Dayong, Y1 - 2018/06/13/ PY - 2018/04/26/received PY - 2018/06/05/revised PY - 2018/06/09/accepted PY - 2018/6/18/pubmed PY - 2019/6/5/medline PY - 2018/6/18/entrez KW - Caenorhabditis elegans KW - Combinational effect KW - Environmentally relevant concentrations KW - Nanopolystyrene particles KW - Titanium dioxide nanoparticles SP - 444 EP - 450 JF - Ecotoxicology and environmental safety JO - Ecotoxicol Environ Saf VL - 161 N2 - The possible adverse effects of nanoplastics have received the great attention recently; however, their effects at environmentally relevant concentration on organisms are still largely unclear. We here employed Caenorhabditis elegans to investigate the combinational effects of titanium dioxide nanoparticles (TiO2-NPs) and nanopolystyrene particles at environmentally relevant concentrations on organisms. In wild-type nematodes, prolonged exposure to nanopolystyrene particles (1 μg/L) could enhance the toxicity of TiO2-NPs (1 μg/L) in decreasing locomotion behavior and in inducing intestinal reactive oxygen species (ROS) production. Meanwhile, combinational exposure to TiO2-NPs (1 μg/L) and nanopolystyrene particles (1 μg/L) altered the molecular basis for oxidative stress in wild-type nematodes. Moreover, prolonged exposure to nanopolystyrene particles (0.1 μg/L) could further enhance the toxicity of TiO2-NPs (1 μg/L) in decreasing locomotion behavior and in inducing intestinal ROS production in sod-3 mutant nematodes. Our data suggest the potential role of nanopolystyrene particles at environmentally relevant concentrations in enhancing the toxicity of ENMs in the environment. SN - 1090-2414 UR - https://www.unboundmedicine.com/medline/citation/29909313/Combinational_effect_of_titanium_dioxide_nanoparticles_and_nanopolystyrene_particles_at_environmentally_relevant_concentrations_on_nematode_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -