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Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study.
Biol Trace Elem Res. 2019 Feb; 187(2):376-382.BT

Abstract

Some trace elements may participate in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). This study aimed to investigate the trace element status of zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), and lead (Pb) in children with ADHD, and to compare them with normal controls. Associations between examined elements and SNAP-IV rating scores of ADHD symptoms were also assessed. Four hundred nineteen children with ADHD (8.8 ± 2.1 years) and 395 matched normal controls (8.9 ± 1.7 years) were recruited in the study. The concentrations of Zn, Fe, Cu, Mg, and Pb in the whole blood were measured by atomic absorption spectrometry. Lower zinc levels (P < 0.001) and the number out of normal ranges (P = 0.015) were found in children with ADHD when compared with the normal control group. The difference remained when adjusting the factor of BMI z-score. No significant between-group differences were found in levels of other elements. Zinc levels were negatively correlated with parent-rated scores of inattentive subscale of SNAP-IV (r = - 0.40) as well as with total score of SNAP-IV (r = - 0.24). Other significant associations were not observed. The present results indicated that there were alterations in blood levels of zinc, which was associated with the symptom scores of ADHD.

Authors+Show Affiliations

Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, No.57, Zhuganxiang Road, Hangzhou, Zhejiang Province, China. colortea@zju.edu.cn.Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, No.57, Zhuganxiang Road, Hangzhou, Zhejiang Province, China.Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, No.57, Zhuganxiang Road, Hangzhou, Zhejiang Province, China.Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, No.57, Zhuganxiang Road, Hangzhou, Zhejiang Province, China.Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, No.57, Zhuganxiang Road, Hangzhou, Zhejiang Province, China.Department of Child Health Care, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29909491

Citation

Yang, Rongwang, et al. "Blood Levels of Trace Elements in Children With Attention-Deficit Hyperactivity Disorder: Results From a Case-Control Study." Biological Trace Element Research, vol. 187, no. 2, 2019, pp. 376-382.
Yang R, Zhang Y, Gao W, et al. Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study. Biol Trace Elem Res. 2019;187(2):376-382.
Yang, R., Zhang, Y., Gao, W., Lin, N., Li, R., & Zhao, Z. (2019). Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study. Biological Trace Element Research, 187(2), 376-382. https://doi.org/10.1007/s12011-018-1408-9
Yang R, et al. Blood Levels of Trace Elements in Children With Attention-Deficit Hyperactivity Disorder: Results From a Case-Control Study. Biol Trace Elem Res. 2019;187(2):376-382. PubMed PMID: 29909491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood Levels of Trace Elements in Children with Attention-Deficit Hyperactivity Disorder: Results from a Case-Control Study. AU - Yang,Rongwang, AU - Zhang,Yanyi, AU - Gao,Weijia, AU - Lin,Nannan, AU - Li,Rong, AU - Zhao,Zhengyan, Y1 - 2018/06/16/ PY - 2018/04/10/received PY - 2018/06/05/accepted PY - 2018/6/18/pubmed PY - 2019/6/15/medline PY - 2018/6/18/entrez KW - Attention-deficit hyperactivity disorder (ADHD) KW - BMI z-score KW - Trace element KW - Zinc SP - 376 EP - 382 JF - Biological trace element research JO - Biol Trace Elem Res VL - 187 IS - 2 N2 - Some trace elements may participate in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). This study aimed to investigate the trace element status of zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg), and lead (Pb) in children with ADHD, and to compare them with normal controls. Associations between examined elements and SNAP-IV rating scores of ADHD symptoms were also assessed. Four hundred nineteen children with ADHD (8.8 ± 2.1 years) and 395 matched normal controls (8.9 ± 1.7 years) were recruited in the study. The concentrations of Zn, Fe, Cu, Mg, and Pb in the whole blood were measured by atomic absorption spectrometry. Lower zinc levels (P < 0.001) and the number out of normal ranges (P = 0.015) were found in children with ADHD when compared with the normal control group. The difference remained when adjusting the factor of BMI z-score. No significant between-group differences were found in levels of other elements. Zinc levels were negatively correlated with parent-rated scores of inattentive subscale of SNAP-IV (r = - 0.40) as well as with total score of SNAP-IV (r = - 0.24). Other significant associations were not observed. The present results indicated that there were alterations in blood levels of zinc, which was associated with the symptom scores of ADHD. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/29909491/Blood_Levels_of_Trace_Elements_in_Children_with_Attention_Deficit_Hyperactivity_Disorder:_Results_from_a_Case_Control_Study_ L2 - https://dx.doi.org/10.1007/s12011-018-1408-9 DB - PRIME DP - Unbound Medicine ER -