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Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension.
Int J Chron Obstruct Pulmon Dis 2018; 13:1803-1808IJ

Abstract

Aim

The aim of the current study was to assess the serum levels of trace minerals/heavy metals in COPD patients with and without pulmonary hypertension (PH) and to investigate their correlations to demographic, clinical, and biochemical variables.

Materials and methods

This cross-sectional study was performed in Van Yuzuncu Yil University Medical Faculty between April 2013 and July 2013. Cases were allocated into three groups: Group 1 consisted of severe COPD patients; Group 2 was made up of COPD patients with PH; and healthy controls constituted Group 3. Demographic, radiological, and biochemical variables, as well as the serum levels of trace minerals and heavy metals, were noted and compared in these three groups.

Results

COPD patients were older and had higher rates of smoking habit, diabetes mellitus, and hypertension compared to the control group. Carotid intima-media thickness was increased bilaterally, and serum levels of Co, Cu, and Fe were higher in COPD patients. Left carotid intima-media thickness was increased, and serum levels of Cd, Co, and Fe were found to be higher in COPD cases with PH compared to COPD patients without PH.

Conclusion

Our results show that serum levels of trace minerals and heavy metals may be altered in COPD and PH.

Authors+Show Affiliations

Department of Chest Diseases, Faculty of Medicine, Dursun Odabas Medical Center, Van Yuzuncu Yil University, Van, Turkey.Department of Cardiology, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey.Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey.Department of Internal Medicine, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.Department of Chest Diseases, Medical Faculty, Mugla University, Mugla, Turkey.Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey.Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29910610

Citation

Asker, Selvi, et al. "Serum Levels of Trace Minerals and Heavy Metals in Severe COPD Patients With and Without Pulmonary Hypertension." International Journal of Chronic Obstructive Pulmonary Disease, vol. 13, 2018, pp. 1803-1808.
Asker S, Asker M, Yeltekin AC, et al. Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension. Int J Chron Obstruct Pulmon Dis. 2018;13:1803-1808.
Asker, S., Asker, M., Yeltekin, A. C., Aslan, M., Ozbay, B., Demir, H., & Turan, H. (2018). Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension. International Journal of Chronic Obstructive Pulmonary Disease, 13, pp. 1803-1808. doi:10.2147/COPD.S164431.
Asker S, et al. Serum Levels of Trace Minerals and Heavy Metals in Severe COPD Patients With and Without Pulmonary Hypertension. Int J Chron Obstruct Pulmon Dis. 2018;13:1803-1808. PubMed PMID: 29910610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension. AU - Asker,Selvi, AU - Asker,Muntecep, AU - Yeltekin,Asli Cilingir, AU - Aslan,Mehmet, AU - Ozbay,Bulent, AU - Demir,Halit, AU - Turan,Hakan, Y1 - 2018/05/31/ PY - 2018/6/19/entrez PY - 2018/6/19/pubmed PY - 2019/1/17/medline KW - chronic obstructive pulmonary disease KW - pulmonary hypertension SP - 1803 EP - 1808 JF - International journal of chronic obstructive pulmonary disease JO - Int J Chron Obstruct Pulmon Dis VL - 13 N2 - Aim: The aim of the current study was to assess the serum levels of trace minerals/heavy metals in COPD patients with and without pulmonary hypertension (PH) and to investigate their correlations to demographic, clinical, and biochemical variables. Materials and methods: This cross-sectional study was performed in Van Yuzuncu Yil University Medical Faculty between April 2013 and July 2013. Cases were allocated into three groups: Group 1 consisted of severe COPD patients; Group 2 was made up of COPD patients with PH; and healthy controls constituted Group 3. Demographic, radiological, and biochemical variables, as well as the serum levels of trace minerals and heavy metals, were noted and compared in these three groups. Results: COPD patients were older and had higher rates of smoking habit, diabetes mellitus, and hypertension compared to the control group. Carotid intima-media thickness was increased bilaterally, and serum levels of Co, Cu, and Fe were higher in COPD patients. Left carotid intima-media thickness was increased, and serum levels of Cd, Co, and Fe were found to be higher in COPD cases with PH compared to COPD patients without PH. Conclusion: Our results show that serum levels of trace minerals and heavy metals may be altered in COPD and PH. SN - 1178-2005 UR - https://www.unboundmedicine.com/medline/citation/29910610/Serum_levels_of_trace_minerals_and_heavy_metals_in_severe_COPD_patients_with_and_without_pulmonary_hypertension_ L2 - https://dx.doi.org/10.2147/COPD.S164431 DB - PRIME DP - Unbound Medicine ER -