Tags

Type your tag names separated by a space and hit enter

Detection and identification of designer drugs by nanoparticle-based NMR chemosensing.
Chem Sci. 2018 Jun 07; 9(21):4777-4784.CS

Abstract

Properly designed monolayer-protected nanoparticles (2 nm core diameter) can be used as nanoreceptors for selective detection and identification of phenethylamine derivatives (designer drugs) in water. The molecular recognition mechanism is driven by the combination of electrostatic and hydrophobic interactions within the coating monolayer. Each nanoparticle can bind up to 30-40 analyte molecules. The affinity constants range from 105 to 106 M-1 and are modulated by the hydrophobicity of the aromatic moiety in the substrate. Detection of drug candidates (such as amphetamines and methamphetamines) is performed by using magnetization (NOE) or saturation (STD) transfer NMR experiments. In this way, the NMR spectrum of the drug is isolated from that of the mixture, allowing broad-class multianalyte detection and even identification of unknowns. The introduction of a dimethylsilane moiety in the coating monolayer allows performing STD experiments in complex mixtures. In this way, a detection limit of 30 μM is reached with standard instruments.

Authors+Show Affiliations

Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.Dipartimento di Scienze Chimiche , Università di Padova , Via Marzolo 1 , 35131 Padova , Italy . Email: fabrizio.mancin@unipd.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29910928

Citation

Gabrielli, Luca, et al. "Detection and Identification of Designer Drugs By Nanoparticle-based NMR Chemosensing." Chemical Science, vol. 9, no. 21, 2018, pp. 4777-4784.
Gabrielli L, Rosa-Gastaldo D, Salvia MV, et al. Detection and identification of designer drugs by nanoparticle-based NMR chemosensing. Chem Sci. 2018;9(21):4777-4784.
Gabrielli, L., Rosa-Gastaldo, D., Salvia, M. V., Springhetti, S., Rastrelli, F., & Mancin, F. (2018). Detection and identification of designer drugs by nanoparticle-based NMR chemosensing. Chemical Science, 9(21), 4777-4784. https://doi.org/10.1039/c8sc01283k
Gabrielli L, et al. Detection and Identification of Designer Drugs By Nanoparticle-based NMR Chemosensing. Chem Sci. 2018 Jun 7;9(21):4777-4784. PubMed PMID: 29910928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection and identification of designer drugs by nanoparticle-based NMR chemosensing. AU - Gabrielli,Luca, AU - Rosa-Gastaldo,Daniele, AU - Salvia,Marie-Virginie, AU - Springhetti,Sara, AU - Rastrelli,Federico, AU - Mancin,Fabrizio, Y1 - 2018/04/25/ PY - 2018/03/19/received PY - 2018/04/22/accepted PY - 2018/6/19/entrez PY - 2018/6/19/pubmed PY - 2018/6/19/medline SP - 4777 EP - 4784 JF - Chemical science JO - Chem Sci VL - 9 IS - 21 N2 - Properly designed monolayer-protected nanoparticles (2 nm core diameter) can be used as nanoreceptors for selective detection and identification of phenethylamine derivatives (designer drugs) in water. The molecular recognition mechanism is driven by the combination of electrostatic and hydrophobic interactions within the coating monolayer. Each nanoparticle can bind up to 30-40 analyte molecules. The affinity constants range from 105 to 106 M-1 and are modulated by the hydrophobicity of the aromatic moiety in the substrate. Detection of drug candidates (such as amphetamines and methamphetamines) is performed by using magnetization (NOE) or saturation (STD) transfer NMR experiments. In this way, the NMR spectrum of the drug is isolated from that of the mixture, allowing broad-class multianalyte detection and even identification of unknowns. The introduction of a dimethylsilane moiety in the coating monolayer allows performing STD experiments in complex mixtures. In this way, a detection limit of 30 μM is reached with standard instruments. SN - 2041-6520 UR - https://www.unboundmedicine.com/medline/citation/29910928/Detection_and_identification_of_designer_drugs_by_nanoparticle-based_NMR_chemosensing L2 - https://doi.org/10.1039/c8sc01283k DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.