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Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status.

Abstract

Increasing evidence points at a role for the immune system in the genesis of the alcohol hangover. This study investigated the association between self-reported immune function and experiencing hangovers. Dutch students aged 18 to 30 years old were invited to complete an online survey. Eighteen items on immune-related complaints were completed to assess self-reported immune function. Alcohol consumption in the past month (with respect to usual consumption and the occasion of heaviest drinking) was also recorded. Subjects with an estimated blood alcohol concentration (eBAC) of 0.18% or higher on their heaviest drinking occasion in the prior month were included in the analyses. Self-reported immune function was compared between drinkers with a hangover and those who claimed to be hangover resistant. In total, of 481 subjects (79.2% women) with a mean (SD) age of 21.1 (1.9) years old were included in the analysis. Of these, 83.3% (n = 400) reported having hangovers and 16.8% (n = 81) claimed to be hangover resistant. Drinkers with hangovers had significantly higher self-reported overall immune function scores when compared to hangover-resistant drinkers (mean ± SD = 10.5 ± 3.6 versus 13.1 ± 4.9, p = 0.0001), indicating a poorer immune status. In conclusion, experiencing alcohol hangovers is associated with significantly poorer self-reported immune function.

Authors+Show Affiliations

Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. a.j.a.e.vandeloo@uu.nl. Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands. a.j.a.e.vandeloo@uu.nl.Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. M.Mackus@uu.nl.Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. m.vanschrojensteinlantman@students.uu.nl.Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. a.d.kraneveld@uu.nl. Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands. a.d.kraneveld@uu.nl.Faculty of Behavioral and Social Sciences, Groningen University, 9712TS Groningen, The Netherlands. k.a.brookhuis@rug.nl.Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. j.garssen@uu.nl. Nutricia Research, 3584CT Utrecht, The Netherlands. j.garssen@uu.nl.Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia. andrew@scholeylab.com.Division of Pharmacology, Utrecht University, 3584CG Utrecht, The Netherlands. j.c.verster@uu.nl. Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3584CM Utrecht, The Netherlands. j.c.verster@uu.nl. Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia. j.c.verster@uu.nl.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29912152

Citation

van de Loo, Aurora J A E., et al. "Susceptibility to Alcohol Hangovers: the Association With Self-Reported Immune Status." International Journal of Environmental Research and Public Health, vol. 15, no. 6, 2018.
van de Loo AJAE, Mackus M, van Schrojenstein Lantman M, et al. Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status. Int J Environ Res Public Health. 2018;15(6).
van de Loo, A. J. A. E., Mackus, M., van Schrojenstein Lantman, M., Kraneveld, A. D., Brookhuis, K. A., Garssen, J., ... Verster, J. C. (2018). Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status. International Journal of Environmental Research and Public Health, 15(6), doi:10.3390/ijerph15061286.
van de Loo AJAE, et al. Susceptibility to Alcohol Hangovers: the Association With Self-Reported Immune Status. Int J Environ Res Public Health. 2018 06 18;15(6) PubMed PMID: 29912152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Susceptibility to Alcohol Hangovers: The Association with Self-Reported Immune Status. AU - van de Loo,Aurora J A E, AU - Mackus,Marlou, AU - van Schrojenstein Lantman,Marith, AU - Kraneveld,Aletta D, AU - Brookhuis,Karel A, AU - Garssen,Johan, AU - Scholey,Andrew, AU - Verster,Joris C, Y1 - 2018/06/18/ PY - 2018/05/29/received PY - 2018/06/10/revised PY - 2018/06/12/accepted PY - 2018/6/19/entrez PY - 2018/6/19/pubmed PY - 2019/1/15/medline KW - alcohol KW - hangover KW - immune function KW - resistance JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 15 IS - 6 N2 - Increasing evidence points at a role for the immune system in the genesis of the alcohol hangover. This study investigated the association between self-reported immune function and experiencing hangovers. Dutch students aged 18 to 30 years old were invited to complete an online survey. Eighteen items on immune-related complaints were completed to assess self-reported immune function. Alcohol consumption in the past month (with respect to usual consumption and the occasion of heaviest drinking) was also recorded. Subjects with an estimated blood alcohol concentration (eBAC) of 0.18% or higher on their heaviest drinking occasion in the prior month were included in the analyses. Self-reported immune function was compared between drinkers with a hangover and those who claimed to be hangover resistant. In total, of 481 subjects (79.2% women) with a mean (SD) age of 21.1 (1.9) years old were included in the analysis. Of these, 83.3% (n = 400) reported having hangovers and 16.8% (n = 81) claimed to be hangover resistant. Drinkers with hangovers had significantly higher self-reported overall immune function scores when compared to hangover-resistant drinkers (mean ± SD = 10.5 ± 3.6 versus 13.1 ± 4.9, p = 0.0001), indicating a poorer immune status. In conclusion, experiencing alcohol hangovers is associated with significantly poorer self-reported immune function. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/29912152/Susceptibility_to_Alcohol_Hangovers:_The_Association_with_Self_Reported_Immune_Status_ L2 - http://www.mdpi.com/resolver?pii=ijerph15061286 DB - PRIME DP - Unbound Medicine ER -