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[Bisalbuminemia: A case report].
Rev Med Interne. 2018 Dec; 39(12):950-954.RM

Abstract

INTRODUCTION

Bisalbuminemias consist in rare qualitative modifications of several aspects in the albumin pattern. Bisalbuminemias, most of which are not pathological, can be observed using capillary electrophoresis.

CASE REPORTS

We report a case of hereditary bisalbuminemia diagnosed by chance while exploring chronic unexplained hypereosinophilia in a 42-year-old patient. The patient's normal lipid profile, the lack of an antibiotic treatment or pancreatic pathology, and the persistence of the bisalbuminemia after one month, suggested a diagnosis of genetic bisalbuminemia. In light of other such cases, we review the main causes of bisalbuminemia, both genetic and acquired.

CONCLUSION

The diagnosis of genetic bisalbuminemia is made by first eliminating the usual acquired etiologies: analytical or drug interference, acute pancreatitis and binding of immunoglobulins. Then, after having checked the lipemic index, reviewed the patient's medical history, comorbidities, and treatments, repeating the electrophoresis will help identify the cause of the bisalbuminemia.

Authors+Show Affiliations

Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France. Electronic address: bertrand.lefrere@aphp.fr.Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.Fédération des laboratoires, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94163 Saint-Mandé, France; École du Val-de-Grâce, 1, place Alphonse-Laveran, 75005 Paris, France.École du Val-de-Grâce, 1, place Alphonse-Laveran, 75005 Paris, France; Service de médecine interne et d'oncologie médicale, hôpital d'instruction des armées Bégin, 69, avenue de Paris, 94163 Saint-Mandé, France.Fédération des laboratoires, hôpital d'instruction des armées Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France.

Pub Type(s)

Case Reports
Journal Article

Language

fre

PubMed ID

29914710

Citation

Lefrère, B, et al. "[Bisalbuminemia: a Case Report]." La Revue De Medecine Interne, vol. 39, no. 12, 2018, pp. 950-954.
Lefrère B, Dedôme E, Garcia-Hejl C, et al. [Bisalbuminemia: A case report]. Rev Med Interne. 2018;39(12):950-954.
Lefrère, B., Dedôme, E., Garcia-Hejl, C., Ragot, C., Chianea, D., Delacour, H., Cremades, S., & Vest, P. (2018). [Bisalbuminemia: A case report]. La Revue De Medecine Interne, 39(12), 950-954. https://doi.org/10.1016/j.revmed.2018.05.010
Lefrère B, et al. [Bisalbuminemia: a Case Report]. Rev Med Interne. 2018;39(12):950-954. PubMed PMID: 29914710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bisalbuminemia: A case report]. AU - Lefrère,B, AU - Dedôme,E, AU - Garcia-Hejl,C, AU - Ragot,C, AU - Chianea,D, AU - Delacour,H, AU - Cremades,S, AU - Vest,P, Y1 - 2018/06/18/ PY - 2018/01/06/received PY - 2018/05/10/revised PY - 2018/05/21/accepted PY - 2018/6/20/pubmed PY - 2019/2/12/medline PY - 2018/6/20/entrez KW - Bisalbuminemia KW - Bisalbuminémie KW - Drug interference KW - Interférence médicamenteuse KW - Serum protein electrophoresis KW - Électrophorèse des protéines sériques SP - 950 EP - 954 JF - La Revue de medecine interne JO - Rev Med Interne VL - 39 IS - 12 N2 - INTRODUCTION: Bisalbuminemias consist in rare qualitative modifications of several aspects in the albumin pattern. Bisalbuminemias, most of which are not pathological, can be observed using capillary electrophoresis. CASE REPORTS: We report a case of hereditary bisalbuminemia diagnosed by chance while exploring chronic unexplained hypereosinophilia in a 42-year-old patient. The patient's normal lipid profile, the lack of an antibiotic treatment or pancreatic pathology, and the persistence of the bisalbuminemia after one month, suggested a diagnosis of genetic bisalbuminemia. In light of other such cases, we review the main causes of bisalbuminemia, both genetic and acquired. CONCLUSION: The diagnosis of genetic bisalbuminemia is made by first eliminating the usual acquired etiologies: analytical or drug interference, acute pancreatitis and binding of immunoglobulins. Then, after having checked the lipemic index, reviewed the patient's medical history, comorbidities, and treatments, repeating the electrophoresis will help identify the cause of the bisalbuminemia. SN - 1768-3122 UR - https://www.unboundmedicine.com/medline/citation/29914710/[Bisalbuminemia:_A_case_report]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0248-8663(18)30581-2 DB - PRIME DP - Unbound Medicine ER -