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Botanicals and Hepatotoxicity.
Clin Pharmacol Ther 2018; 104(3):458-469CP

Abstract

The use of botanicals, often in the form of multi-ingredient herbal dietary supplements (HDS), has grown tremendously in the past three decades despite their unproven efficacy. This is paralleled by an increase in dietary supplement-related health complications, notably hepatotoxicity. This article reviews the demographics and motivations of dietary supplement (DS) consumers and the regulatory framework for DS in the US and other developed countries. It examines in detail three groups of multi-ingredient HDS associated with hepatotoxicity: OxyElite Pro (two formulations), green tea extract-based DS, and "designer anabolic steroids." These examples illustrate the difficulties in identifying and adjudicating causality of suspect compound(s) of multi-ingredient HDS-associated liver injury in the clinical setting. The article outlines future directions for further study of HDS-associated hepatotoxicity as well as measures to safeguard the consumer against it.

Authors+Show Affiliations

University of California San Francisco, Fresno, California, USA.Fresno, California, USA.Einstein Medical Center, Philadelphia, Pennsylvania, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29920648

Citation

Roytman, Marina M., et al. "Botanicals and Hepatotoxicity." Clinical Pharmacology and Therapeutics, vol. 104, no. 3, 2018, pp. 458-469.
Roytman MM, Poerzgen P, Navarro V. Botanicals and Hepatotoxicity. Clin Pharmacol Ther. 2018;104(3):458-469.
Roytman, M. M., Poerzgen, P., & Navarro, V. (2018). Botanicals and Hepatotoxicity. Clinical Pharmacology and Therapeutics, 104(3), pp. 458-469. doi:10.1002/cpt.1097.
Roytman MM, Poerzgen P, Navarro V. Botanicals and Hepatotoxicity. Clin Pharmacol Ther. 2018;104(3):458-469. PubMed PMID: 29920648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Botanicals and Hepatotoxicity. AU - Roytman,Marina M, AU - Poerzgen,Peter, AU - Navarro,Victor, Y1 - 2018/06/19/ PY - 2018/03/12/received PY - 2018/04/18/revised PY - 2018/04/19/accepted PY - 2018/6/20/pubmed PY - 2019/8/27/medline PY - 2018/6/20/entrez SP - 458 EP - 469 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 104 IS - 3 N2 - The use of botanicals, often in the form of multi-ingredient herbal dietary supplements (HDS), has grown tremendously in the past three decades despite their unproven efficacy. This is paralleled by an increase in dietary supplement-related health complications, notably hepatotoxicity. This article reviews the demographics and motivations of dietary supplement (DS) consumers and the regulatory framework for DS in the US and other developed countries. It examines in detail three groups of multi-ingredient HDS associated with hepatotoxicity: OxyElite Pro (two formulations), green tea extract-based DS, and "designer anabolic steroids." These examples illustrate the difficulties in identifying and adjudicating causality of suspect compound(s) of multi-ingredient HDS-associated liver injury in the clinical setting. The article outlines future directions for further study of HDS-associated hepatotoxicity as well as measures to safeguard the consumer against it. SN - 1532-6535 UR - https://www.unboundmedicine.com/medline/citation/29920648/Botanicals_and_Hepatotoxicity_ L2 - https://doi.org/10.1002/cpt.1097 DB - PRIME DP - Unbound Medicine ER -