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Effects of different n6/n3 ratios and supplementation with DHA and EPA on the testicular histology and lipogenesis in streptozotocin-treated rats.
Andrologia 2018; 50(8):e13067A

Abstract

The aim of this study was to investigate the possible influence of different dietary n6/n3 ratios and DHA/EPA addition on the testis histology, antioxidative status and lipogenesis of streptozotocin-treated rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). The rats were divided into five groups: CON (n6/n3 ratio, 7), CON-DM1 (STZ; n6/n3 ratio, 7), N3-DM1 (STZ; n6/n3 ratio, 1), N6-DM1 (STZ; n6/n3 ratio, 60) and DHA-DM1 (STZ; n6/n3 ratio, 1; added DHA/EPA). Antioxidative status was improved in the DHA-DM1 group. Seminiferous tubule diameter, testicular pathohistological scoring and total lipid content were improved in the N6-DM1 group compared to the other streptozotocin-treated groups. Streptozotocin treatment induced changes in testis fatty acid profile depending on n6/n3 ratio. The fatty acid profile of N6-DM1 group was characterised by similar or increased values for n6 fatty acids compared to the CON group, while the DHA-DM1 group had the lowest content of n6 fatty acids. The content of n3 fatty acids was increased in the N3-DM1 and DHA-DM1 groups. These results suggest that a n6/n3 ratio could significantly influence testicular antioxidative status, histology and lipogenesis and that these effects vary depending on the supplemented fatty acid.

Authors+Show Affiliations

Faculty of Veterinary Medicine, Department of Animal Husbandry, University of Zagreb, Zagreb, Croatia.Faculty of Veterinary Medicine, Department of Animal Husbandry, University of Zagreb, Zagreb, Croatia.Faculty of Veterinary Medicine, VetMedZg ERA Chair project, University of Zagreb, Zagreb, Croatia.Faculty of Veterinary Medicine, Department of Veterinary Pathology, University of Zagreb, Zagreb, Croatia.Faculty of Veterinary Medicine, Department of Animal Nutrition and Dietetics, University of Zagreb, Zagreb, Croatia.

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

29920748

Citation

Starčević, Kristina, et al. "Effects of Different N6/n3 Ratios and Supplementation With DHA and EPA On the Testicular Histology and Lipogenesis in Streptozotocin-treated Rats." Andrologia, vol. 50, no. 8, 2018, pp. e13067.
Starčević K, Maurić M, Galan A, et al. Effects of different n6/n3 ratios and supplementation with DHA and EPA on the testicular histology and lipogenesis in streptozotocin-treated rats. Andrologia. 2018;50(8):e13067.
Starčević, K., Maurić, M., Galan, A., Gudan Kurilj, A., & Mašek, T. (2018). Effects of different n6/n3 ratios and supplementation with DHA and EPA on the testicular histology and lipogenesis in streptozotocin-treated rats. Andrologia, 50(8), pp. e13067. doi:10.1111/and.13067.
Starčević K, et al. Effects of Different N6/n3 Ratios and Supplementation With DHA and EPA On the Testicular Histology and Lipogenesis in Streptozotocin-treated Rats. Andrologia. 2018;50(8):e13067. PubMed PMID: 29920748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of different n6/n3 ratios and supplementation with DHA and EPA on the testicular histology and lipogenesis in streptozotocin-treated rats. AU - Starčević,Kristina, AU - Maurić,Maja, AU - Galan,Asier, AU - Gudan Kurilj,Andrea, AU - Mašek,Tomislav, Y1 - 2018/06/19/ PY - 2018/01/25/received PY - 2018/03/15/revised PY - 2018/05/17/accepted PY - 2018/6/20/pubmed PY - 2019/1/15/medline PY - 2018/6/20/entrez KW - lipid peroxidation KW - n6/n3 ratio KW - streptozotocin KW - testicular lipogenesis SP - e13067 EP - e13067 JF - Andrologia JO - Andrologia VL - 50 IS - 8 N2 - The aim of this study was to investigate the possible influence of different dietary n6/n3 ratios and DHA/EPA addition on the testis histology, antioxidative status and lipogenesis of streptozotocin-treated rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg). The rats were divided into five groups: CON (n6/n3 ratio, 7), CON-DM1 (STZ; n6/n3 ratio, 7), N3-DM1 (STZ; n6/n3 ratio, 1), N6-DM1 (STZ; n6/n3 ratio, 60) and DHA-DM1 (STZ; n6/n3 ratio, 1; added DHA/EPA). Antioxidative status was improved in the DHA-DM1 group. Seminiferous tubule diameter, testicular pathohistological scoring and total lipid content were improved in the N6-DM1 group compared to the other streptozotocin-treated groups. Streptozotocin treatment induced changes in testis fatty acid profile depending on n6/n3 ratio. The fatty acid profile of N6-DM1 group was characterised by similar or increased values for n6 fatty acids compared to the CON group, while the DHA-DM1 group had the lowest content of n6 fatty acids. The content of n3 fatty acids was increased in the N3-DM1 and DHA-DM1 groups. These results suggest that a n6/n3 ratio could significantly influence testicular antioxidative status, histology and lipogenesis and that these effects vary depending on the supplemented fatty acid. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/29920748/Effects_of_different_n6/n3_ratios_and_supplementation_with_DHA_and_EPA_on_the_testicular_histology_and_lipogenesis_in_streptozotocin_treated_rats_ L2 - https://doi.org/10.1111/and.13067 DB - PRIME DP - Unbound Medicine ER -