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Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans.
Zoonoses Public Health. 2018 09; 65(6):711-727.ZP

Abstract

Rodents serve as the natural reservoir and vector for a variety of pathogens, some of which are responsible for severe and life-threatening disease in humans. Despite the significant impact in humans many of these viruses, including Old and New World hantaviruses as well as Arenaviruses, most have no specific vaccine or therapeutic to treat or prevent human infection. The recent success of wildlife vaccines to mitigate rabies in animal populations offers interesting insight into the use of similar strategies for other zoonotic agents of human disease. In this review, we discuss the notion of using baited vaccines as a means to interrupt the transmission of viral pathogens between rodent reservoirs and to susceptible human hosts.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mendoza EJ
Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Warner B
Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
Kobinger G
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Centre Hospitalier de l'Université Laval, Quebec City, Quebec, Canada.
Ogden NH
Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, St-Hyacinthe, Quebec, Canada.
Safronetz D
Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.

MeSH

AnimalsAnimals, WildCommunicable Diseases, EmergingDisease ReservoirsOrthohantavirusHantavirus InfectionsHumansRodentiaViral VaccinesZoonoses

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29931738

Citation

Mendoza, Emelissa J., et al. "Baited Vaccines: a Strategy to Mitigate Rodent-borne Viral Zoonoses in Humans." Zoonoses and Public Health, vol. 65, no. 6, 2018, pp. 711-727.
Mendoza EJ, Warner B, Kobinger G, et al. Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans. Zoonoses Public Health. 2018;65(6):711-727.
Mendoza, E. J., Warner, B., Kobinger, G., Ogden, N. H., & Safronetz, D. (2018). Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans. Zoonoses and Public Health, 65(6), 711-727. https://doi.org/10.1111/zph.12487
Mendoza EJ, et al. Baited Vaccines: a Strategy to Mitigate Rodent-borne Viral Zoonoses in Humans. Zoonoses Public Health. 2018;65(6):711-727. PubMed PMID: 29931738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baited vaccines: A strategy to mitigate rodent-borne viral zoonoses in humans. AU - Mendoza,Emelissa J, AU - Warner,Bryce, AU - Kobinger,Gary, AU - Ogden,Nicholas H, AU - Safronetz,David, Y1 - 2018/06/21/ PY - 2018/03/17/received PY - 2018/06/05/revised PY - 2018/05/21/accepted PY - 2018/6/23/pubmed PY - 2019/8/24/medline PY - 2018/6/23/entrez KW - Lassa virus KW - emerging infectious diseases KW - hantavirus KW - wildlife vaccines KW - zoonotic diseases SP - 711 EP - 727 JF - Zoonoses and public health JO - Zoonoses Public Health VL - 65 IS - 6 N2 - Rodents serve as the natural reservoir and vector for a variety of pathogens, some of which are responsible for severe and life-threatening disease in humans. Despite the significant impact in humans many of these viruses, including Old and New World hantaviruses as well as Arenaviruses, most have no specific vaccine or therapeutic to treat or prevent human infection. The recent success of wildlife vaccines to mitigate rabies in animal populations offers interesting insight into the use of similar strategies for other zoonotic agents of human disease. In this review, we discuss the notion of using baited vaccines as a means to interrupt the transmission of viral pathogens between rodent reservoirs and to susceptible human hosts. SN - 1863-2378 UR - https://www.unboundmedicine.com/medline/citation/29931738/Baited_vaccines:_A_strategy_to_mitigate_rodent_borne_viral_zoonoses_in_humans_ DB - PRIME DP - Unbound Medicine ER -