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Reestablishment of sperm quality after long-term deslorelin suppression in tomcats.
Anim Reprod Sci 2018; 195:302-308AR

Abstract

The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2-4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22-25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23-28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats.

Authors+Show Affiliations

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, CABA, C1425FQB, Argentina; Cátedra y Servicio de Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, CABA, C1425FQB, Argentina; Cátedra y Servicio de Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, CABA, C1425FQB, Argentina; Cátedra y Servicio de Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.Cátedra de Epidemiología y Salud Pública, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.Medical Department, Virbac laboratory, Carros, France.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, CABA, C1425FQB, Argentina; Cátedra y Servicio de Reproducción Animal, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, La Plata, B1900AVW, Buenos Aires, Argentina.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, CABA, C1425FQB, Argentina. Electronic address: astornel@fcv.unlp.edu.ar.

Pub Type(s)

Clinical Trial, Veterinary
Journal Article

Language

eng

PubMed ID

29934121

Citation

Nuñez Favre, Romina, et al. "Reestablishment of Sperm Quality After Long-term Deslorelin Suppression in Tomcats." Animal Reproduction Science, vol. 195, 2018, pp. 302-308.
Nuñez Favre R, García MF, García Mitacek MC, et al. Reestablishment of sperm quality after long-term deslorelin suppression in tomcats. Anim Reprod Sci. 2018;195:302-308.
Nuñez Favre, R., García, M. F., García Mitacek, M. C., Rearte, R., Fontaine, C., de la Sota, R. L., & Stornelli, M. A. (2018). Reestablishment of sperm quality after long-term deslorelin suppression in tomcats. Animal Reproduction Science, 195, pp. 302-308. doi:10.1016/j.anireprosci.2018.06.008.
Nuñez Favre R, et al. Reestablishment of Sperm Quality After Long-term Deslorelin Suppression in Tomcats. Anim Reprod Sci. 2018;195:302-308. PubMed PMID: 29934121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reestablishment of sperm quality after long-term deslorelin suppression in tomcats. AU - Nuñez Favre,Romina, AU - García,María Florencia, AU - García Mitacek,María Carla, AU - Rearte,Ramiro, AU - Fontaine,Christelle, AU - de la Sota,Rodolfo Luzbel, AU - Stornelli,María Alejandra, Y1 - 2018/06/18/ PY - 2018/02/02/received PY - 2018/06/07/revised PY - 2018/06/15/accepted PY - 2018/6/24/pubmed PY - 2019/10/11/medline PY - 2018/6/24/entrez KW - Contraception KW - Deslorelin KW - GnRH agonist KW - Semen KW - Testicular volume KW - Testosterone SP - 302 EP - 308 JF - Animal reproduction science JO - Anim. Reprod. Sci. VL - 195 N2 - The aim of the study was to determine the time after treatment with a 4.7 mg deslorelin implant until Tomcat spermatogenesis activity was restored, and seminal parameters reached pre-implant values. Tomcats (n = 6) were randomly assigned to one of two treatments. Three cats (n = 3) received a deslorelin implant (4.7 mG; Suprelorin®, Virbac, France) in the interscapular subcutaneous region whereas three (n = 3) received no implant and served as control group. Semen samples were collected by electroejaculation every 4 wk from 3 mo before treatment (pretreatment samples) until reestablishment of pre-treatment sperm quality, 32 mo post-implant insertion (PI). Each semen sample was assessed for motility, velocity, concentration, total sperm count, viability, acrosome integrity, plasma membrane integrity and sperm morphology. After semen collection, testicular volume and presence/absence of penile spines were recorded. Additionally, blood samples were taken to measure testosterone concentration. An increase in sperm concentration and total sperm count was present 1 mo PI despite of an abrupt decrease in serum testosterone concentrations after 2-4 weeks. This initial stimulatory effect was followed by a decrease in seminal parameters, reduction of testicular volume and disappearance of penile spines 2 mo PI. A single Suprelorin® 4.7 mg implant suppressed sperm production for 22-25 months. No clinically side effect was observed during the study period. All toms returned to their initial seminal quality 23-28 months after treatment. Therefore, we conclude that Suprelorin® 4.7 mg is a safe option for reversible reproduction control during long periods in tomcats. SN - 1873-2232 UR - https://www.unboundmedicine.com/medline/citation/29934121/Reestablishment_of_sperm_quality_after_long_term_deslorelin_suppression_in_tomcats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4320(18)30125-8 DB - PRIME DP - Unbound Medicine ER -