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Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects.
Brain Stimul 2018 Sep - Oct; 11(5):1033-1043BS

Abstract

BACKGROUND

Previous research has typically focussed on the neuromodulatory effects of direct currents applied over single regions of the cortex. However, complex processes such as working memory (WM) strongly rely on activations across a wider neural network and therefore might benefit from stimulation administered over multiple cortical targets.

OBJECTIVE

We examined the neurobiological and cognitive effects of High-Definition transcranial direct current stimulation (HD-tDCS) montages that either targeted the dorsolateral prefrontal cortex (DLPFC) alone, or simultaneously stimulated the DLPFC and parietal cortex (DLPFC + PC).

METHODS

In a within-subjects design, 16 healthy participants completed three experimental sessions in which they received HD-tDCS over either the DLPFC, the DLPFC + PC or sham stimulation. Changes in cortical reactivity were examined using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), while oscillatory power was measured via EEG recorded during n-back tasks. WM performance was also examined across several separate tasks.

RESULTS

Stimulation using both the DLPFC or DLPFC + PC montages modulated cortical reactivity, as indexed by potentiation of the P60 TMS-evoked potential. However, only the dual-site DLPFC + PC stimulation produced a reduction in the amplitude of the N100 component, relative to baseline. Increases in theta and gamma power were also observed following this montage, when compared to baseline, but were not present following HD-tDCS over the DLPFC alone. Despite these neurophysiological changes, WM performance was not significantly modulated by HD-tDCS, regardless of stimulation montage.

CONCLUSION

These results provide important initial insight into the behavioural and biological effects of stimulation over key cortical regions linked to WM and attest to the sensitivity of TMS-EEG and EEG in detecting subtle neurophysiological changes induced by HD-tDCS.

Authors+Show Affiliations

Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Victoria, Australia. Electronic address: aron.hill@monash.edu.Brain and Mental Health Laboratory, School of Psychological Sciences and Monash Biomedical Imaging, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia.Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Victoria, Australia; Epworth Healthcare, Camberwell, Victoria, Australia.Monash Alfred Psychiatry Research Centre, The Alfred and Monash University, Central Clinical School, Victoria, Australia.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29936014

Citation

Hill, Aron T., et al. "Effects of Single Versus Dual-site High-Definition Transcranial Direct Current Stimulation (HD-tDCS) On Cortical Reactivity and Working Memory Performance in Healthy Subjects." Brain Stimulation, vol. 11, no. 5, 2018, pp. 1033-1043.
Hill AT, Rogasch NC, Fitzgerald PB, et al. Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects. Brain Stimul. 2018;11(5):1033-1043.
Hill, A. T., Rogasch, N. C., Fitzgerald, P. B., & Hoy, K. E. (2018). Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects. Brain Stimulation, 11(5), pp. 1033-1043. doi:10.1016/j.brs.2018.06.005.
Hill AT, et al. Effects of Single Versus Dual-site High-Definition Transcranial Direct Current Stimulation (HD-tDCS) On Cortical Reactivity and Working Memory Performance in Healthy Subjects. Brain Stimul. 2018;11(5):1033-1043. PubMed PMID: 29936014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of single versus dual-site High-Definition transcranial direct current stimulation (HD-tDCS) on cortical reactivity and working memory performance in healthy subjects. AU - Hill,Aron T, AU - Rogasch,Nigel C, AU - Fitzgerald,Paul B, AU - Hoy,Kate E, Y1 - 2018/06/18/ PY - 2018/02/02/received PY - 2018/05/12/revised PY - 2018/06/12/accepted PY - 2018/6/25/pubmed PY - 2019/3/12/medline PY - 2018/6/25/entrez KW - DLPFC KW - EEG KW - HD-tDCS KW - TMS-EEG KW - Working memory SP - 1033 EP - 1043 JF - Brain stimulation JO - Brain Stimul VL - 11 IS - 5 N2 - BACKGROUND: Previous research has typically focussed on the neuromodulatory effects of direct currents applied over single regions of the cortex. However, complex processes such as working memory (WM) strongly rely on activations across a wider neural network and therefore might benefit from stimulation administered over multiple cortical targets. OBJECTIVE: We examined the neurobiological and cognitive effects of High-Definition transcranial direct current stimulation (HD-tDCS) montages that either targeted the dorsolateral prefrontal cortex (DLPFC) alone, or simultaneously stimulated the DLPFC and parietal cortex (DLPFC + PC). METHODS: In a within-subjects design, 16 healthy participants completed three experimental sessions in which they received HD-tDCS over either the DLPFC, the DLPFC + PC or sham stimulation. Changes in cortical reactivity were examined using transcranial magnetic stimulation combined with electroencephalography (TMS-EEG), while oscillatory power was measured via EEG recorded during n-back tasks. WM performance was also examined across several separate tasks. RESULTS: Stimulation using both the DLPFC or DLPFC + PC montages modulated cortical reactivity, as indexed by potentiation of the P60 TMS-evoked potential. However, only the dual-site DLPFC + PC stimulation produced a reduction in the amplitude of the N100 component, relative to baseline. Increases in theta and gamma power were also observed following this montage, when compared to baseline, but were not present following HD-tDCS over the DLPFC alone. Despite these neurophysiological changes, WM performance was not significantly modulated by HD-tDCS, regardless of stimulation montage. CONCLUSION: These results provide important initial insight into the behavioural and biological effects of stimulation over key cortical regions linked to WM and attest to the sensitivity of TMS-EEG and EEG in detecting subtle neurophysiological changes induced by HD-tDCS. SN - 1876-4754 UR - https://www.unboundmedicine.com/medline/citation/29936014/Effects_of_single_versus_dual_site_High_Definition_transcranial_direct_current_stimulation__HD_tDCS__on_cortical_reactivity_and_working_memory_performance_in_healthy_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1935-861X(18)30197-9 DB - PRIME DP - Unbound Medicine ER -