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Vitamin D and parathyroid hormone in relation to bone health in Croatian women.
Arch Osteoporos. 2018 06 24; 13(1):69.AO

Abstract

In N = 400 women (46.9 ± 15.5 years), the prevalence of severe (< 25 nmol/l) and mild (≥ 25 and < 50 nmol/l) 25(OH)D deficiency was 7 and 32.2%, respectively, while 60.8% women had adequate status. Serum iPTH increased (> 37.0 pg/ml) when 25(OH)D was < 46.9 nmol/l. BMD was not significantly lower in the participants with iPTH > 37.0 pg/ml.

PURPOSE

Bone mineral density (BMD) is affected by serum 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (iPTH). Our objective was to analyze the association between serum 25(OH)D and iPTH and their mutual regulatory influence on BMD in women with 25(OH)D deficiency. We also attempted to establish a threshold for the serum 25(OH)D below which serum iPTH increases.

METHODS

The participants were 400 generally healthy women (46.9 ± 15.5 years) recruited from local communities. BMD was measured by dual-energy X-ray absorptiometry, and serum 25(OH)D, iPTH, calcium, phosphorus, alkaline phosphatase, osteocalcin, and C-telopeptide (CTX) were analyzed from the fasting blood samples. Multivariate regression models were used to investigate the relationships among serum 25(OH)D, iPTH, and BMD.

RESULTS

Serum iPTH increased when 25(OH)D concentrations were below 46.9 nmol/l. Severe 25(OH)D deficiency (< 25 nmol/l) was found in 7% of the participants and was associated with significantly higher iPTH compared to participants with serum 25(OH)D ≥ 25 nmol/l. BMD was negatively associated with iPTH only in the group with severe 25(OH)D deficiency. However, BMD was not significantly lower in the participants with severe 25(OH)D deficiency compared to those with mild deficiency or with adequate status.

CONCLUSIONS

Our results showed that threshold level of 25(OH)D below which iPTH started to rise was 46.9 nmol/l. There was no negative impact of iPTH on BMD or bone turnover markers in women with severe 25(OH)D deficiency. This might be due to the relatively young age of our participants in whom the unfavorable effect of 25(OH)D deficiency on bone might have not yet appeared.

Authors+Show Affiliations

Laboratory for Nutrition Science, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, Zagreb, Croatia. ikeser@pbf.hr.Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, Zagreb, Croatia.Laboratory for Food Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, Zagreb, Croatia.Laboratory for Food Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, Zagreb, Croatia.Institute for Successful Longevity, Florida State University, Tallahassee, FL, 32311, USA.Laboratory for Nutrition Science, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, Zagreb, Croatia.Laboratory for Nutrition Science, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, Zagreb, Croatia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29936589

Citation

Keser, Irena, et al. "Vitamin D and Parathyroid Hormone in Relation to Bone Health in Croatian Women." Archives of Osteoporosis, vol. 13, no. 1, 2018, p. 69.
Keser I, Cvijetić S, Bituh M, et al. Vitamin D and parathyroid hormone in relation to bone health in Croatian women. Arch Osteoporos. 2018;13(1):69.
Keser, I., Cvijetić, S., Bituh, M., Rumora Samarin, I., Ilich, J. Z., Colić Barić, I., & Rumbak, I. (2018). Vitamin D and parathyroid hormone in relation to bone health in Croatian women. Archives of Osteoporosis, 13(1), 69. https://doi.org/10.1007/s11657-018-0483-z
Keser I, et al. Vitamin D and Parathyroid Hormone in Relation to Bone Health in Croatian Women. Arch Osteoporos. 2018 06 24;13(1):69. PubMed PMID: 29936589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and parathyroid hormone in relation to bone health in Croatian women. AU - Keser,Irena, AU - Cvijetić,Selma, AU - Bituh,Martina, AU - Rumora Samarin,Ivana, AU - Ilich,Jasminka Z, AU - Colić Barić,Irena, AU - Rumbak,Ivana, Y1 - 2018/06/24/ PY - 2018/03/08/received PY - 2018/05/31/accepted PY - 2018/6/25/entrez PY - 2018/6/25/pubmed PY - 2019/6/14/medline KW - Bone mineral density KW - C-telopeptide KW - Osteocalcin KW - PTH KW - Vitamin D SP - 69 EP - 69 JF - Archives of osteoporosis JO - Arch Osteoporos VL - 13 IS - 1 N2 - : In N = 400 women (46.9 ± 15.5 years), the prevalence of severe (< 25 nmol/l) and mild (≥ 25 and < 50 nmol/l) 25(OH)D deficiency was 7 and 32.2%, respectively, while 60.8% women had adequate status. Serum iPTH increased (> 37.0 pg/ml) when 25(OH)D was < 46.9 nmol/l. BMD was not significantly lower in the participants with iPTH > 37.0 pg/ml. PURPOSE: Bone mineral density (BMD) is affected by serum 25-hydroxyvitamin D (25(OH)D) and intact parathyroid hormone (iPTH). Our objective was to analyze the association between serum 25(OH)D and iPTH and their mutual regulatory influence on BMD in women with 25(OH)D deficiency. We also attempted to establish a threshold for the serum 25(OH)D below which serum iPTH increases. METHODS: The participants were 400 generally healthy women (46.9 ± 15.5 years) recruited from local communities. BMD was measured by dual-energy X-ray absorptiometry, and serum 25(OH)D, iPTH, calcium, phosphorus, alkaline phosphatase, osteocalcin, and C-telopeptide (CTX) were analyzed from the fasting blood samples. Multivariate regression models were used to investigate the relationships among serum 25(OH)D, iPTH, and BMD. RESULTS: Serum iPTH increased when 25(OH)D concentrations were below 46.9 nmol/l. Severe 25(OH)D deficiency (< 25 nmol/l) was found in 7% of the participants and was associated with significantly higher iPTH compared to participants with serum 25(OH)D ≥ 25 nmol/l. BMD was negatively associated with iPTH only in the group with severe 25(OH)D deficiency. However, BMD was not significantly lower in the participants with severe 25(OH)D deficiency compared to those with mild deficiency or with adequate status. CONCLUSIONS: Our results showed that threshold level of 25(OH)D below which iPTH started to rise was 46.9 nmol/l. There was no negative impact of iPTH on BMD or bone turnover markers in women with severe 25(OH)D deficiency. This might be due to the relatively young age of our participants in whom the unfavorable effect of 25(OH)D deficiency on bone might have not yet appeared. SN - 1862-3514 UR - https://www.unboundmedicine.com/medline/citation/29936589/Vitamin_D_and_parathyroid_hormone_in_relation_to_bone_health_in_Croatian_women_ L2 - https://dx.doi.org/10.1007/s11657-018-0483-z DB - PRIME DP - Unbound Medicine ER -