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Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial.
Br J Nutr. 2018 07; 120(1):57-63.BJ

Abstract

Ubiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels.

Authors+Show Affiliations

1Department of Family and Community Medicine,Chung Shan Medical University Hospital,40201 Taichung,Taiwan.3Division of Dietetics & Nutrition,Taichung Tzu Chi Hospital,Buddhist Tzu Chi Medical Foundation,42743 Taichung,Taiwan.2School of Medicine,Chung Shan Medical University,40201 Taichung,Taiwan.5Department of Nutrition,Chung Shan Medical University,40201 Taichung,Taiwan.5Department of Nutrition,Chung Shan Medical University,40201 Taichung,Taiwan.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29936921

Citation

Yen, Chi-Hua, et al. "Effect of Liquid Ubiquinol Supplementation On Glucose, Lipids and Antioxidant Capacity in Type 2 Diabetes Patients: a Double-blind, Randomised, Placebo-controlled Trial." The British Journal of Nutrition, vol. 120, no. 1, 2018, pp. 57-63.
Yen CH, Chu YJ, Lee BJ, et al. Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial. Br J Nutr. 2018;120(1):57-63.
Yen, C. H., Chu, Y. J., Lee, B. J., Lin, Y. C., & Lin, P. T. (2018). Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial. The British Journal of Nutrition, 120(1), 57-63. https://doi.org/10.1017/S0007114518001241
Yen CH, et al. Effect of Liquid Ubiquinol Supplementation On Glucose, Lipids and Antioxidant Capacity in Type 2 Diabetes Patients: a Double-blind, Randomised, Placebo-controlled Trial. Br J Nutr. 2018;120(1):57-63. PubMed PMID: 29936921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial. AU - Yen,Chi-Hua, AU - Chu,Ying-Ju, AU - Lee,Bor-Jen, AU - Lin,Yi-Chin, AU - Lin,Ping-Ting, PY - 2018/6/26/entrez PY - 2018/6/26/pubmed PY - 2019/9/4/medline KW - CAT catalase KW - GPx glutathione peroxidase KW - HOMA-IR homoeostatic model assessment of insulin resistance KW - HbA1c glyco Hb KW - MES medication effect scores KW - SOD superoxide dismutase KW - Antioxidants KW - Glucose KW - Liquids KW - Type 2 diabetes KW - Ubiquinol SP - 57 EP - 63 JF - The British journal of nutrition JO - Br J Nutr VL - 120 IS - 1 N2 - Ubiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/29936921/Effect_of_liquid_ubiquinol_supplementation_on_glucose_lipids_and_antioxidant_capacity_in_type_2_diabetes_patients:_a_double_blind_randomised_placebo_controlled_trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114518001241/type/journal_article DB - PRIME DP - Unbound Medicine ER -