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[A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 06 25; 35(3):415-420.SW

Abstract

A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children.

Authors+Show Affiliations

Department of Psychology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.Radiology Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.Radiology Department, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R.China.Mental Health Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R.China.dryangchuang@163.com.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29938950

Citation

Zhou, Jiaxiu, et al. "[A Multi-parameter Resting-state Functional Magnetic Resonance Imaging Study of Brain Intrinsic Activity in Attention Deficit Hyperactivity Disorder Children]." Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, vol. 35, no. 3, 2018, pp. 415-420.
Zhou J, Gao Y, Bu X, et al. [A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018;35(3):415-420.
Zhou, J., Gao, Y., Bu, X., Li, H., Liang, Y., Chen, H., Wang, M., Lin, F., Yang, C., & Huang, X. (2018). [A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, 35(3), 415-420. https://doi.org/10.7507/1001-5515.201801001
Zhou J, et al. [A Multi-parameter Resting-state Functional Magnetic Resonance Imaging Study of Brain Intrinsic Activity in Attention Deficit Hyperactivity Disorder Children]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 06 25;35(3):415-420. PubMed PMID: 29938950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A multi-parameter resting-state functional magnetic resonance imaging study of brain intrinsic activity in attention deficit hyperactivity disorder children]. AU - Zhou,Jiaxiu, AU - Gao,Yingxue, AU - Bu,Xuan, AU - Li,Hailong, AU - Liang,Yan, AU - Chen,Hong, AU - Wang,Meihao, AU - Lin,Feifei, AU - Yang,Chuang, AU - Huang,Xiaoqi, PY - 2018/6/26/entrez PY - 2018/6/26/pubmed PY - 2019/7/16/medline KW - attention-deficit/hyperactivity disorder KW - degree centrality KW - functional magnetic resonance imaging KW - regional homogeneity KW - voxel-mirrored homotopic connectivity SP - 415 EP - 420 JF - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi JO - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi VL - 35 IS - 3 N2 - A great number of studies have demonstrated functional abnormalities in children with attention-deficit/hyperactivity disorder (ADHD), although conflicting results have also been reported. And few studies analyzed homotopic functional connectivity between hemispheres. In this study, resting-state functional magnetic resonance imaging (MRI) data were recorded from 45 medication-naïve ADHD children and 26 healthy controls. The regional homogeneity (ReHo), degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values were compared between the two groups to depict the intrinsic brain activities. We found that ADHD children exhibited significantly lower ReHo and DC values in the right middle frontal gyrus and the two values correlated with each other; moreover, lower VMHC values were found in the bilateral occipital lobes of ADHD children, which was negatively related with anxiety scores of Conners' Parent Rating Scale (CPRS-R) and positively related with completed categories of Wisconsin Card Sorting Test (WCST). Our results might suggest that less spontaneous neuronal activities of the right middle frontal gyrus and the bilateral occipital lobes in ADHD children. SN - 1001-5515 UR - https://www.unboundmedicine.com/medline/citation/29938950/[A_multi_parameter_resting_state_functional_magnetic_resonance_imaging_study_of_brain_intrinsic_activity_in_attention_deficit_hyperactivity_disorder_children]_ L2 - http://www.diseaseinfosearch.org/result/659 DB - PRIME DP - Unbound Medicine ER -