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Acetyl Fentanyl: Trends and Concentrations in Metro Detroit.
J Forensic Sci 2019; 64(1):149-153JF

Abstract

Acetyl fentanyl (N-[1-phenethylpiperidin-4-yl]-N-phenylacetamide) is a potent opioid analgesic with no medicinal uses. We report deaths between 2016 and 2017 at the Medical Examiner's Office in Detroit, MI where acetyl fentanyl was found in the decedent's blood and compare them to previously published deaths between 2015 and 2016. The recent cases (cohort B) had a mean acetyl fentanyl concentration of 0.9 ng/mL (range: 0.1-5.3 ng/mL) and an associated higher concentration of fentanyl along with multiple other drugs present. The older cases (cohort A) had higher concentrations of acetyl fentanyl (mean: 8.9 ng/mL; range: 0.28-37 ng/mL) with lower, yet still toxic, concentrations of fentanyl. We conclude that the cause of death in these recent cases was likely multiple drug toxicity with fentanyl and that the consistently observed lower peripheral blood concentrations of acetyl fentanyl are most likely an artifact in the manufacture of the consumed illicit fentanyl.

Authors+Show Affiliations

Michigan Medicine Department of Pathology/Wayne County Medical Examiner's Office, 1300 E Warren Ave, Detroit, MI, 48207.Michigan Medicine Department of Pathology/Wayne County Medical Examiner's Office, 1300 E Warren Ave, Detroit, MI, 48207.National Medical Services, 3701 Welsh Road, Willow Grove, PA, 19090.Department of Forensic Pathology, Auckland City Hospital, PO Box 110031, Auckland, New Zealand, 1148.Michigan Medicine Department of Pathology/Wayne County Medical Examiner's Office, 1300 E Warren Ave, Detroit, MI, 48207.Michigan Medicine Department of Pathology/Wayne County Medical Examiner's Office, 1300 E Warren Ave, Detroit, MI, 48207.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29940698

Citation

Avedschmidt, Sarah, et al. "Acetyl Fentanyl: Trends and Concentrations in Metro Detroit." Journal of Forensic Sciences, vol. 64, no. 1, 2019, pp. 149-153.
Avedschmidt S, Schmidt C, Isenschmid D, et al. Acetyl Fentanyl: Trends and Concentrations in Metro Detroit. J Forensic Sci. 2019;64(1):149-153.
Avedschmidt, S., Schmidt, C., Isenschmid, D., Kesha, K., Moons, D., & Gupta, A. (2019). Acetyl Fentanyl: Trends and Concentrations in Metro Detroit. Journal of Forensic Sciences, 64(1), pp. 149-153. doi:10.1111/1556-4029.13840.
Avedschmidt S, et al. Acetyl Fentanyl: Trends and Concentrations in Metro Detroit. J Forensic Sci. 2019;64(1):149-153. PubMed PMID: 29940698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetyl Fentanyl: Trends and Concentrations in Metro Detroit. AU - Avedschmidt,Sarah, AU - Schmidt,Carl, AU - Isenschmid,Daniel, AU - Kesha,Kilak, AU - Moons,David, AU - Gupta,Avneesh, Y1 - 2018/06/25/ PY - 2018/02/19/received PY - 2018/04/10/revised PY - 2018/05/15/revised PY - 2018/05/24/accepted PY - 2018/6/26/pubmed PY - 2018/6/26/medline PY - 2018/6/26/entrez KW - acetyl fentanyl KW - fentanyl KW - forensic pathology KW - forensic science KW - forensic toxicology KW - opioid abuse KW - overdose KW - synthetic opioids SP - 149 EP - 153 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 64 IS - 1 N2 - Acetyl fentanyl (N-[1-phenethylpiperidin-4-yl]-N-phenylacetamide) is a potent opioid analgesic with no medicinal uses. We report deaths between 2016 and 2017 at the Medical Examiner's Office in Detroit, MI where acetyl fentanyl was found in the decedent's blood and compare them to previously published deaths between 2015 and 2016. The recent cases (cohort B) had a mean acetyl fentanyl concentration of 0.9 ng/mL (range: 0.1-5.3 ng/mL) and an associated higher concentration of fentanyl along with multiple other drugs present. The older cases (cohort A) had higher concentrations of acetyl fentanyl (mean: 8.9 ng/mL; range: 0.28-37 ng/mL) with lower, yet still toxic, concentrations of fentanyl. We conclude that the cause of death in these recent cases was likely multiple drug toxicity with fentanyl and that the consistently observed lower peripheral blood concentrations of acetyl fentanyl are most likely an artifact in the manufacture of the consumed illicit fentanyl. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/29940698/Acetyl_Fentanyl:_Trends_and_Concentrations_in_Metro_Detroit L2 - https://doi.org/10.1111/1556-4029.13840 DB - PRIME DP - Unbound Medicine ER -