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Effect of prenatal EPA and DHA on maternal and umbilical cord blood cytokines.
BMC Pregnancy Childbirth. 2018 Jun 26; 18(1):261.BP

Abstract

BACKGROUND

Investigators have hypothesized that omega-3 fatty acid supplementation may modulate the immune response. However, available evidence is conflicting. We performed this study to investigate the effect of prenatal eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-rich fish oil supplementation on maternal and fetal cytokine production.

METHODS

This study is a secondary analysis of a randomized controlled trial designed to assess whether prenatal EPA- or DHA-rich fish oil supplementation would prevent perinatal depressive symptoms among women at risk. Enrolled participants received EPA-rich fish oil (1060 mg EPA plus 274 mg DHA), DHA-rich fish oil (900 mg DHA plus 180 mg EPA) or soy oil placebo. Maternal venous blood was collected at enrollment (12-20 weeks gestation) and after supplementation (34-36 weeks gestation). Umbilical cord blood was collected at delivery. We analyzed stored plasma specimens for 16 human cytokines using multiplex immunoassays. Maternal and cord blood cytokine levels were compared among the treatment groups. Associations of serum DHA and EPA with maternal and cord blood cytokines were explored via regression analysis.

RESULTS

We enrolled 126 women, of whom 118 completed the trial. Prenatal supplementation with EPA-rich fish oil significantly lowered maternal IL6, IL15, and TNFα concentrations. However, supplementation with DHA-rich fish oil had no significant effect on maternal cytokine profiles. Maternal serum DHA fraction was significantly associated with IL1α, and maternal serum DHA and EPA fractions were significantly associated with IL 10 concentrations after supplementation. Compared with placebo, supplementation with EPA- or DHA-rich fish oils had no significant effect on cord blood cytokine concentrations.

CONCLUSIONS

Prenatal supplementation with EPA-rich fish oil significantly reduced levels of several inflammatory cytokines in maternal plasma, while prenatal DHA-rich fish oil had no significant effect on cytokine concentrations. Supplementation with EPA- and DHA- rich fish oil had no significant effect on umbilical cord blood cytokine concentrations.

TRIAL REGISTRATION

Clinical Trial Registration: registration number NCT00711971 7/7/2008.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM, 87131, USA. emozurkewich@salud.unm.edu.Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.Obstetrics and Gynecology, Duke University, Durham, NC, USA.Obstetrics and Gynecology, Spectrum Health Maternal Fetal Medicine, Grand Rapids, MI/Michigan State University College of Human Medicine, East Lansing, MI, USA.Department of Obstetrics and Gynecology, University of New Mexico School of Medicine, MSC 10 5580, 1 University of New Mexico, Albuquerque, NM, 87131, USA.Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.Clinical and Translational Center, University of New Mexico, Albuquerque, NM, USA.Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29940888

Citation

Mozurkewich, Ellen L., et al. "Effect of Prenatal EPA and DHA On Maternal and Umbilical Cord Blood Cytokines." BMC Pregnancy and Childbirth, vol. 18, no. 1, 2018, p. 261.
Mozurkewich EL, Berman DR, Vahratian A, et al. Effect of prenatal EPA and DHA on maternal and umbilical cord blood cytokines. BMC Pregnancy Childbirth. 2018;18(1):261.
Mozurkewich, E. L., Berman, D. R., Vahratian, A., Clinton, C. M., Romero, V. C., Chilimigras, J. L., Vazquez, D., Qualls, C., & Djuric, Z. (2018). Effect of prenatal EPA and DHA on maternal and umbilical cord blood cytokines. BMC Pregnancy and Childbirth, 18(1), 261. https://doi.org/10.1186/s12884-018-1899-6
Mozurkewich EL, et al. Effect of Prenatal EPA and DHA On Maternal and Umbilical Cord Blood Cytokines. BMC Pregnancy Childbirth. 2018 Jun 26;18(1):261. PubMed PMID: 29940888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of prenatal EPA and DHA on maternal and umbilical cord blood cytokines. AU - Mozurkewich,Ellen L, AU - Berman,Deborah R, AU - Vahratian,Anjel, AU - Clinton,Chelsea M, AU - Romero,Vivian C, AU - Chilimigras,Julie L, AU - Vazquez,Delia, AU - Qualls,Clifford, AU - Djuric,Zora, Y1 - 2018/06/26/ PY - 2017/12/04/received PY - 2018/06/14/accepted PY - 2018/6/27/entrez PY - 2018/6/27/pubmed PY - 2019/3/28/medline KW - Cytokines KW - DHA KW - EPA KW - Umbilical cord blood SP - 261 EP - 261 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 18 IS - 1 N2 - BACKGROUND: Investigators have hypothesized that omega-3 fatty acid supplementation may modulate the immune response. However, available evidence is conflicting. We performed this study to investigate the effect of prenatal eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-rich fish oil supplementation on maternal and fetal cytokine production. METHODS: This study is a secondary analysis of a randomized controlled trial designed to assess whether prenatal EPA- or DHA-rich fish oil supplementation would prevent perinatal depressive symptoms among women at risk. Enrolled participants received EPA-rich fish oil (1060 mg EPA plus 274 mg DHA), DHA-rich fish oil (900 mg DHA plus 180 mg EPA) or soy oil placebo. Maternal venous blood was collected at enrollment (12-20 weeks gestation) and after supplementation (34-36 weeks gestation). Umbilical cord blood was collected at delivery. We analyzed stored plasma specimens for 16 human cytokines using multiplex immunoassays. Maternal and cord blood cytokine levels were compared among the treatment groups. Associations of serum DHA and EPA with maternal and cord blood cytokines were explored via regression analysis. RESULTS: We enrolled 126 women, of whom 118 completed the trial. Prenatal supplementation with EPA-rich fish oil significantly lowered maternal IL6, IL15, and TNFα concentrations. However, supplementation with DHA-rich fish oil had no significant effect on maternal cytokine profiles. Maternal serum DHA fraction was significantly associated with IL1α, and maternal serum DHA and EPA fractions were significantly associated with IL 10 concentrations after supplementation. Compared with placebo, supplementation with EPA- or DHA-rich fish oils had no significant effect on cord blood cytokine concentrations. CONCLUSIONS: Prenatal supplementation with EPA-rich fish oil significantly reduced levels of several inflammatory cytokines in maternal plasma, while prenatal DHA-rich fish oil had no significant effect on cytokine concentrations. Supplementation with EPA- and DHA- rich fish oil had no significant effect on umbilical cord blood cytokine concentrations. TRIAL REGISTRATION: Clinical Trial Registration: registration number NCT00711971 7/7/2008. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/29940888/Effect_of_prenatal_EPA_and_DHA_on_maternal_and_umbilical_cord_blood_cytokines_ DB - PRIME DP - Unbound Medicine ER -