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Risk factors for developing diabetes after 3 years among community-dwelling elderly with impaired fasting glucose.
J Diabetes 2019; 11(2):107-114JD

Abstract

BACKGROUND

The aim of the present study was to examine the risk factors for developing diabetes after 3 years in an elderly Chinese suburban population with impaired fasting glucose (IFG).

METHODS

The study population comprised residents of the Hangu area of Tianjin, China, with IFG, aged ≥60 years, who joined the national free physical examination program (n = 328; mean [±SD] age 68.0 ±6.1 years; 48.2% men). Diabetes was defined by self-report of a physician's diagnosis or fasting plasma glucose (FPG) ≥7.0 mmol/L; IFG was defined as FPG ≥5.6 and < 7.0 mmol/L. Risk factors of incident diabetes at the 3-year follow-up were analyzed individually using logistic regression analysis.

RESULTS

Between baseline and the 3-year follow-up, 56 subjects with IFG at baseline had developed diabetes. After multivariate adjustment for demographic and clinical factors, the incidence of diabetes increased with higher FPG (odds ratio [OR] 9.30, 95% confidence interval [CI] 2.84-30.48), but decreased with the grip strength/weight ratio (OR 0.88, 95% CI 0.82-0.94). Moreover, the combination of higher FPG and lower grip strength/weight was associated with a higher incidence of diabetes than higher FPG only or lower grip strength/weight (P < 0.05).

CONCLUSION

The present study indicates that higher FPG and lower muscle strength are associated with glycemic deterioration among subjects with IFG after 3 years. The results suggest that not only glucose levels, but also physical performance may be useful markers of the risk of diabetes in this population.

Authors+Show Affiliations

Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China. Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan.Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China.Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan.Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University, Tianjin, China. Department of Rehabilitation and Sports Medicine, Tianjin Medical University, Tianjin, China. Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Tohoku University, Sendai, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29943517

Citation

Zhang, Wen, et al. "Risk Factors for Developing Diabetes After 3 Years Among Community-dwelling Elderly With Impaired Fasting Glucose." Journal of Diabetes, vol. 11, no. 2, 2019, pp. 107-114.
Zhang W, Yang X, Han P, et al. Risk factors for developing diabetes after 3 years among community-dwelling elderly with impaired fasting glucose. J Diabetes. 2019;11(2):107-114.
Zhang, W., Yang, X., Han, P., Ma, Y., Fu, L., Jia, L., ... Guo, Q. (2019). Risk factors for developing diabetes after 3 years among community-dwelling elderly with impaired fasting glucose. Journal of Diabetes, 11(2), pp. 107-114. doi:10.1111/1753-0407.12816.
Zhang W, et al. Risk Factors for Developing Diabetes After 3 Years Among Community-dwelling Elderly With Impaired Fasting Glucose. J Diabetes. 2019;11(2):107-114. PubMed PMID: 29943517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for developing diabetes after 3 years among community-dwelling elderly with impaired fasting glucose. AU - Zhang,Wen, AU - Yang,Xiaolong, AU - Han,Peipei, AU - Ma,Yixuan, AU - Fu,Liyuan, AU - Jia,Liye, AU - Yu,Hairui, AU - Chen,Xiaoyu, AU - Wang,Lu, AU - Hou,Lin, AU - Yu,Xing, AU - Kohzuki,Masahiro, AU - Guo,Qi, Y1 - 2018/07/24/ PY - 2018/03/08/received PY - 2018/06/14/revised PY - 2018/06/20/accepted PY - 2018/6/27/pubmed PY - 2019/3/19/medline PY - 2018/6/27/entrez KW - elderly KW - impaired fasting glucose KW - muscle strength KW - 空腹血糖异常 KW - 老年人 KW - 肌肉力量 SP - 107 EP - 114 JF - Journal of diabetes JO - J Diabetes VL - 11 IS - 2 N2 - BACKGROUND: The aim of the present study was to examine the risk factors for developing diabetes after 3 years in an elderly Chinese suburban population with impaired fasting glucose (IFG). METHODS: The study population comprised residents of the Hangu area of Tianjin, China, with IFG, aged ≥60 years, who joined the national free physical examination program (n = 328; mean [±SD] age 68.0 ±6.1 years; 48.2% men). Diabetes was defined by self-report of a physician's diagnosis or fasting plasma glucose (FPG) ≥7.0 mmol/L; IFG was defined as FPG ≥5.6 and < 7.0 mmol/L. Risk factors of incident diabetes at the 3-year follow-up were analyzed individually using logistic regression analysis. RESULTS: Between baseline and the 3-year follow-up, 56 subjects with IFG at baseline had developed diabetes. After multivariate adjustment for demographic and clinical factors, the incidence of diabetes increased with higher FPG (odds ratio [OR] 9.30, 95% confidence interval [CI] 2.84-30.48), but decreased with the grip strength/weight ratio (OR 0.88, 95% CI 0.82-0.94). Moreover, the combination of higher FPG and lower grip strength/weight was associated with a higher incidence of diabetes than higher FPG only or lower grip strength/weight (P < 0.05). CONCLUSION: The present study indicates that higher FPG and lower muscle strength are associated with glycemic deterioration among subjects with IFG after 3 years. The results suggest that not only glucose levels, but also physical performance may be useful markers of the risk of diabetes in this population. SN - 1753-0407 UR - https://www.unboundmedicine.com/medline/citation/29943517/Risk_factors_for_developing_diabetes_after_3_years_among_community_dwelling_elderly_with_impaired_fasting_glucose_ L2 - https://doi.org/10.1111/1753-0407.12816 DB - PRIME DP - Unbound Medicine ER -