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Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.
Rheumatol Int 2018; 38(8):1413-1428RI

Abstract

Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS). Meta-analysis was conducted using a random-effects model and generic inverse-variance method. Heterogeneity was tested using the I2 statistic index. Treatments with glucosamine and chondroitin were found to significantly reduce pain in VAS [weighted mean difference (WMD) - 7.41 mm, 95% CI - 14.31, - 0.51, p = 0.04 and WMD - 8.35 mm, 95% CI - 11.84, - 4.85, p < 0.00001, respectively]. Their combination did not show this behavior (WMD - 0.28 mm, 95% CI - 8.87, 8.32, p = 0.95). None of the glucosamine, chondroitin or their combination had a significant positive effect on the total WOMAC index and its subscores. Oral supplementation with glucosamine or chondroitin sulfate reduces pain in knee OA. However, there is no additional effect using both therapeutic agents in combination for the management of symptomatic knee OA.

Authors+Show Affiliations

Orthopedics and Traumatology Service, Universidad Autónoma de Nuevo León, University Hospital ''Dr. José Eleuterio González'', Monterrey, Nuevo León, Mexico.Endocrinology Division, Universidad Autónoma de Nuevo León, University Hospital ''Dr. José Eleuterio González'', Monterrey, Nuevo León, Mexico.Orthopedics and Traumatology Service, Universidad Autónoma de Nuevo León, University Hospital ''Dr. José Eleuterio González'', Monterrey, Nuevo León, Mexico.Orthopedics and Traumatology Service, Universidad Autónoma de Nuevo León, University Hospital ''Dr. José Eleuterio González'', Monterrey, Nuevo León, Mexico.Orthopedics and Traumatology Service, Universidad Autónoma de Nuevo León, University Hospital ''Dr. José Eleuterio González'', Monterrey, Nuevo León, Mexico.Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Canoas 100, Col. Los Angeles, 34067, Durango, DGO, Mexico. luis_simental81@hotmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

29947998

Citation

Simental-Mendía, Mario, et al. "Effect of Glucosamine and Chondroitin Sulfate in Symptomatic Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomized Placebo-controlled Trials." Rheumatology International, vol. 38, no. 8, 2018, pp. 1413-1428.
Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, et al. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatol Int. 2018;38(8):1413-1428.
Simental-Mendía, M., Sánchez-García, A., Vilchez-Cavazos, F., Acosta-Olivo, C. A., Peña-Martínez, V. M., & Simental-Mendía, L. E. (2018). Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatology International, 38(8), pp. 1413-1428. doi:10.1007/s00296-018-4077-2.
Simental-Mendía M, et al. Effect of Glucosamine and Chondroitin Sulfate in Symptomatic Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomized Placebo-controlled Trials. Rheumatol Int. 2018;38(8):1413-1428. PubMed PMID: 29947998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. AU - Simental-Mendía,Mario, AU - Sánchez-García,Adriana, AU - Vilchez-Cavazos,Félix, AU - Acosta-Olivo,Carlos A, AU - Peña-Martínez,Víctor M, AU - Simental-Mendía,Luis E, Y1 - 2018/06/11/ PY - 2018/05/08/received PY - 2018/06/02/accepted PY - 2018/6/28/pubmed PY - 2018/12/12/medline PY - 2018/6/28/entrez KW - Chondroitin sulfate KW - Glucosamine KW - Meta-analysis KW - Osteoarthritis KW - Visual analog scale KW - WOMAC SP - 1413 EP - 1428 JF - Rheumatology international JO - Rheumatol. Int. VL - 38 IS - 8 N2 - Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS). Meta-analysis was conducted using a random-effects model and generic inverse-variance method. Heterogeneity was tested using the I2 statistic index. Treatments with glucosamine and chondroitin were found to significantly reduce pain in VAS [weighted mean difference (WMD) - 7.41 mm, 95% CI - 14.31, - 0.51, p = 0.04 and WMD - 8.35 mm, 95% CI - 11.84, - 4.85, p < 0.00001, respectively]. Their combination did not show this behavior (WMD - 0.28 mm, 95% CI - 8.87, 8.32, p = 0.95). None of the glucosamine, chondroitin or their combination had a significant positive effect on the total WOMAC index and its subscores. Oral supplementation with glucosamine or chondroitin sulfate reduces pain in knee OA. However, there is no additional effect using both therapeutic agents in combination for the management of symptomatic knee OA. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/29947998/Effect_of_glucosamine_and_chondroitin_sulfate_in_symptomatic_knee_osteoarthritis:_a_systematic_review_and_meta_analysis_of_randomized_placebo_controlled_trials_ L2 - https://dx.doi.org/10.1007/s00296-018-4077-2 DB - PRIME DP - Unbound Medicine ER -