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Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis.
Eur Radiol. 2018 Dec; 28(12):4940-4948.ER

Abstract

OBJECTIVES

To explore the sensitivity of potential DTI-based biomarkers in detecting microstructural changes for whole-brain white matter in early stage amyotrophic lateral sclerosis (ALS), analyze the relationship between the DTI indices and disease status, and further clarify potential brain regions for disease monitoring and clinical assessment.

METHODS

Thirty-three non-demented ALS patients and 32 age- and gender-matched subjects participated in this study. DTI data were acquired via 3.0T MRI scanner. Maps of diffusion-related indices including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were obtained. Tract-based spatial statistics (TBSS) were used to investigate whole-brain white matter changes of each index. Correlation analyses between both brain-wide and volume-of-interest (VOI)-wide white matter alterations and clinical factors including ALSFRS-R scores, disease duration, and progression rate were performed.

RESULTS

Compared to healthy subjects, ALS patients showed significantly increased RD, MD and reduced FA, mainly along the corticospinal tract (CST) and the body of corpus callosum (CC). Increases in RD were broader than decreases in FA, in CST of both hemispheres. Meanwhile, involvement of several extra-motor regions was also revealed by RD. Significant positive correlation between ALSFRS-R scores and FA, negative correlation between ALSFRS-R and RD were found in left CST.

CONCLUSIONS

RD may be the most sensitive biomarker for the detection of early demyelination of white matter. Both RD and FA may serve as objective biomarkers for disease severity assessment. CST may be the most affected brain region in non-demented ALS.

KEY POINTS

• Changes in RD were broader than those in FA in bilateral CST. • Involvement of extra-motor regions was uncovered by RD. • FA and RD in CST were related to ALSFRS-R scores.

Authors+Show Affiliations

Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China.Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.Department of Radiotherapy, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. gengdy@163.com. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. gengdy@163.com.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai, 200040, China. liyuxin@fudan.edu.cn. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai, China. liyuxin@fudan.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29948064

Citation

Bao, Yifang, et al. "Radial Diffusivity as an Imaging Biomarker for Early Diagnosis of Non-demented Amyotrophic Lateral Sclerosis." European Radiology, vol. 28, no. 12, 2018, pp. 4940-4948.
Bao Y, Yang L, Chen Y, et al. Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis. Eur Radiol. 2018;28(12):4940-4948.
Bao, Y., Yang, L., Chen, Y., Zhang, B., Li, H., Tang, W., Geng, D., & Li, Y. (2018). Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis. European Radiology, 28(12), 4940-4948. https://doi.org/10.1007/s00330-018-5506-z
Bao Y, et al. Radial Diffusivity as an Imaging Biomarker for Early Diagnosis of Non-demented Amyotrophic Lateral Sclerosis. Eur Radiol. 2018;28(12):4940-4948. PubMed PMID: 29948064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis. AU - Bao,Yifang, AU - Yang,Liqin, AU - Chen,Yan, AU - Zhang,Biyun, AU - Li,Haiqing, AU - Tang,Weijun, AU - Geng,Daoying, AU - Li,Yuxin, Y1 - 2018/06/08/ PY - 2018/01/25/received PY - 2018/04/19/accepted PY - 2018/04/09/revised PY - 2018/6/28/pubmed PY - 2019/1/9/medline PY - 2018/6/28/entrez KW - Amyotrophic Lateral Sclerosis KW - Diffusion Tensor Imaging KW - Early Detection of Disease SP - 4940 EP - 4948 JF - European radiology JO - Eur Radiol VL - 28 IS - 12 N2 - OBJECTIVES: To explore the sensitivity of potential DTI-based biomarkers in detecting microstructural changes for whole-brain white matter in early stage amyotrophic lateral sclerosis (ALS), analyze the relationship between the DTI indices and disease status, and further clarify potential brain regions for disease monitoring and clinical assessment. METHODS: Thirty-three non-demented ALS patients and 32 age- and gender-matched subjects participated in this study. DTI data were acquired via 3.0T MRI scanner. Maps of diffusion-related indices including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were obtained. Tract-based spatial statistics (TBSS) were used to investigate whole-brain white matter changes of each index. Correlation analyses between both brain-wide and volume-of-interest (VOI)-wide white matter alterations and clinical factors including ALSFRS-R scores, disease duration, and progression rate were performed. RESULTS: Compared to healthy subjects, ALS patients showed significantly increased RD, MD and reduced FA, mainly along the corticospinal tract (CST) and the body of corpus callosum (CC). Increases in RD were broader than decreases in FA, in CST of both hemispheres. Meanwhile, involvement of several extra-motor regions was also revealed by RD. Significant positive correlation between ALSFRS-R scores and FA, negative correlation between ALSFRS-R and RD were found in left CST. CONCLUSIONS: RD may be the most sensitive biomarker for the detection of early demyelination of white matter. Both RD and FA may serve as objective biomarkers for disease severity assessment. CST may be the most affected brain region in non-demented ALS. KEY POINTS: • Changes in RD were broader than those in FA in bilateral CST. • Involvement of extra-motor regions was uncovered by RD. • FA and RD in CST were related to ALSFRS-R scores. SN - 1432-1084 UR - https://www.unboundmedicine.com/medline/citation/29948064/Radial_diffusivity_as_an_imaging_biomarker_for_early_diagnosis_of_non_demented_amyotrophic_lateral_sclerosis_ L2 - https://dx.doi.org/10.1007/s00330-018-5506-z DB - PRIME DP - Unbound Medicine ER -