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[Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients with Hemotological Maliglancies in the Tropical Region of Hainan].

Abstract

OBJECTIVE

To analyze the infection characteristics of sputum and venous blood pathogen in the patients with hematological malignancies and respiratory symptom in the Hematology Department in tropical region and to investigate its drug-resistance so as to provide etiological evidence for clinical treatment.

METHODS

The pathogens and their drug-resistance of 2466 samples in the patients with hematological malignancies and respiratory symptom in the Department were analyzed retrospectively from January 2013 to November 2017. The samples were collected from sputum and venous blood.

RESULTS

The sputum sample culture in patients with hematologic diseases showed that 224 strains were isolated, out of them 98 strains (43.75%) were fungi mainly candida albicans (41 strains); and then 88 Gram-negative strains (39.28%), among them the main pathogenic bacteria were Escherichia coli(22 strains) and klebsiella Klebsiella pneumoniae(12 strains); and then 38 Gram-positive strains (16.96%), among them the main pathogeni-bacteria were Enteroccocus (14 strains) and Gram-positive bacilli (14 strains). The blood samples culture of patients with hematologic diseases showed that 61 strains were isolated, out of them the isolated rate of Gram-positive bactetia was higherst, which accounted for 55.74%(34/61), mainly including staphylococcus lominis (19 strains); and the isolated rate of Gram-negative bacteria was 44.26% (27/61), among them main pathogenic bacteria was Klebsiella pneumoniae (12 strains). The resistance test of pathogenic bacteria to drugs showed that the resistant rate of Gram-negative bacteria to tigecycline, imipenem and atl-962 duenner was lowest, while the Gram-positive pathogenic bacteria such as Enterococcus, Gram-positive bacilli and Staphylococcus aureus were sensitive to vancomycin, tigecycline and linezolid was high.

CONCLUSION

the patients in hematology department are infected easily in the hospital in tropical region. The main pathogens are fungal strains in the respiratory tract of patients with hematological malignancy according to the sputum culture results. The clinician in tropical regions should choose suitable antibiotics for anti-infective therapy, which is different from the situation in North China or other northern areas.

Authors+Show Affiliations

Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China. E-mail:lipingruirui@163.com.Department of Hematology, Hainan Branch of the General Hospital of the Chinese PLA, Sanya 572000, Hainan Province, China. E-mail:boj301@sina.com.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29950242

Citation

Wang, Mei-Lu, et al. "[Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients With Hemotological Maliglancies in the Tropical Region of Hainan]." Zhongguo Shi Yan Xue Ye Xue Za Zhi, vol. 26, no. 3, 2018, pp. 911-916.
Wang ML, Kuang HH, Cheng LC, et al. [Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients with Hemotological Maliglancies in the Tropical Region of Hainan]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26(3):911-916.
Wang, M. L., Kuang, H. H., Cheng, L. C., Xu, Y. B., Zhao, T. Y., Yang, T., ... Bo, J. (2018). [Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients with Hemotological Maliglancies in the Tropical Region of Hainan]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 26(3), pp. 911-916. doi:10.7534/j.issn.1009-2137.2018.03.047.
Wang ML, et al. [Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients With Hemotological Maliglancies in the Tropical Region of Hainan]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26(3):911-916. PubMed PMID: 29950242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Single Center Analysis of Pathogenic Characteristics of Lung Candida Infection and Other Pathogenic Bacteria Infection in the Patients with Hemotological Maliglancies in the Tropical Region of Hainan]. AU - Wang,Mei-Lu, AU - Kuang,Hui-Hui, AU - Cheng,Long-Can, AU - Xu,Yu-Bing, AU - Zhao,Ting-Yuan, AU - Yang,Ting, AU - Xiang,Song-He, AU - Shu,Cheng-Yuan, AU - Yu,Ping, AU - Dou,Li-Ping, AU - Bo,Jian, PY - 2018/6/29/entrez PY - 2018/6/29/pubmed PY - 2018/11/16/medline SP - 911 EP - 916 JF - Zhongguo shi yan xue ye xue za zhi JO - Zhongguo Shi Yan Xue Ye Xue Za Zhi VL - 26 IS - 3 N2 - OBJECTIVE: To analyze the infection characteristics of sputum and venous blood pathogen in the patients with hematological malignancies and respiratory symptom in the Hematology Department in tropical region and to investigate its drug-resistance so as to provide etiological evidence for clinical treatment. METHODS: The pathogens and their drug-resistance of 2466 samples in the patients with hematological malignancies and respiratory symptom in the Department were analyzed retrospectively from January 2013 to November 2017. The samples were collected from sputum and venous blood. RESULTS: The sputum sample culture in patients with hematologic diseases showed that 224 strains were isolated, out of them 98 strains (43.75%) were fungi mainly candida albicans (41 strains); and then 88 Gram-negative strains (39.28%), among them the main pathogenic bacteria were Escherichia coli(22 strains) and klebsiella Klebsiella pneumoniae(12 strains); and then 38 Gram-positive strains (16.96%), among them the main pathogeni-bacteria were Enteroccocus (14 strains) and Gram-positive bacilli (14 strains). The blood samples culture of patients with hematologic diseases showed that 61 strains were isolated, out of them the isolated rate of Gram-positive bactetia was higherst, which accounted for 55.74%(34/61), mainly including staphylococcus lominis (19 strains); and the isolated rate of Gram-negative bacteria was 44.26% (27/61), among them main pathogenic bacteria was Klebsiella pneumoniae (12 strains). The resistance test of pathogenic bacteria to drugs showed that the resistant rate of Gram-negative bacteria to tigecycline, imipenem and atl-962 duenner was lowest, while the Gram-positive pathogenic bacteria such as Enterococcus, Gram-positive bacilli and Staphylococcus aureus were sensitive to vancomycin, tigecycline and linezolid was high. CONCLUSION: the patients in hematology department are infected easily in the hospital in tropical region. The main pathogens are fungal strains in the respiratory tract of patients with hematological malignancy according to the sputum culture results. The clinician in tropical regions should choose suitable antibiotics for anti-infective therapy, which is different from the situation in North China or other northern areas. SN - 1009-2137 UR - https://www.unboundmedicine.com/medline/citation/29950242/[Single_Center_Analysis_of_Pathogenic_Characteristics_of_Lung_Candida_Infection_and_Other_Pathogenic_Bacteria_Infection_in_the_Patients_with_Hemotological_Maliglancies_in_the_Tropical_Region_of_Hainan]_ L2 - https://medlineplus.gov/yeastinfections.html DB - PRIME DP - Unbound Medicine ER -