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Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease.
J Clin Transl Hepatol 2018; 6(2):135-140JC

Abstract

Background and Aims:

Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients.

Methods:

Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels.

Results:

Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (p >0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5, p <0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (p <0.05).

Conclusions:

Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients.

Authors+Show Affiliations

Department of Medicine, Foundation University Medical College, Islamabad, Pakistan.Department of Medicine, Foundation University Medical College, Islamabad, Pakistan.Department of Medicine, Foundation University Medical College, Islamabad, Pakistan.Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan.Department of Medicine, Fauji Foundation Hospital, Rawalpindi, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29951357

Citation

Jamil, Zubia, et al. "Vitamin D Deficiency and Its Relationship With Child-Pugh Class in Patients With Chronic Liver Disease." Journal of Clinical and Translational Hepatology, vol. 6, no. 2, 2018, pp. 135-140.
Jamil Z, Arif S, Khan A, et al. Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease. J Clin Transl Hepatol. 2018;6(2):135-140.
Jamil, Z., Arif, S., Khan, A., Durrani, A. A., & Yaqoob, N. (2018). Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease. Journal of Clinical and Translational Hepatology, 6(2), pp. 135-140. doi:10.14218/JCTH.2017.00055.
Jamil Z, et al. Vitamin D Deficiency and Its Relationship With Child-Pugh Class in Patients With Chronic Liver Disease. J Clin Transl Hepatol. 2018 Jun 28;6(2):135-140. PubMed PMID: 29951357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease. AU - Jamil,Zubia, AU - Arif,Sharmin, AU - Khan,Anum, AU - Durrani,Asghar Aurangzeb, AU - Yaqoob,Nayyar, Y1 - 2018/02/01/ PY - 2017/08/13/received PY - 2017/10/20/revised PY - 2017/12/12/accepted PY - 2018/6/29/entrez PY - 2018/6/29/pubmed PY - 2018/6/29/medline KW - Liver cirrhosis KW - Liver disease KW - Osteodystrophy KW - Skeletal manifestations KW - Vitamin D deficiency SP - 135 EP - 140 JF - Journal of clinical and translational hepatology JO - J Clin Transl Hepatol VL - 6 IS - 2 N2 - Background and Aims: Skeletal manifestation in liver diseases represents the minimally scrutinized part of the disease spectrum. Vitamin D deficiency has a central role in developing hepatic osteodystrophy in patients with chronic liver disease. This study aimed to investigate vitamin D levels and their relationship with disease advancement in these patients. Methods: Vitamin D levels were checked in 125 chronic liver disease patients. The patients were classified in three stages according to Child-Pugh score: A, B and C. The relationship of vitamin D levels with Child-Pugh score and other variables in the study was assessed by the contingency coefficient. Correlation and logistic regression analyses were also carried out to find additional predictors of low vitamin D levels. Results: Among the patients, 88% had either insufficient or deficient stores of vitamin D, while only 12% had sufficient vitamin D levels (p >0.05). Vitamin D levels were notably related to Child-Pugh class (contingency coefficient = 0.5, p <0.05). On univariate and multinomial regression analyses, age, female sex, MELD and Child-Pugh class were predictors of low vitamin D levels. Age, model of end-stage liver disease score and Child-Pugh score were negatively correlated to vitamin D levels (p <0.05). Conclusions: Vitamin D deficiency is notably related to age, female sex and model of end-stage liver disease score, in addition to Child-Pugh class of liver cirrhosis. Vitamin D levels should be routinely checked in patients with advanced liver cirrhosis (Child-Pugh class B and C) and this deficiency must be addressed in a timely manner to improve general well-being of cirrhotic patients. SN - 2225-0719 UR - https://www.unboundmedicine.com/medline/citation/29951357/Vitamin_D_Deficiency_and_Its_Relationship_with_Child_Pugh_Class_in_Patients_with_Chronic_Liver_Disease_ L2 - https://dx.doi.org/10.14218/JCTH.2017.00055 DB - PRIME DP - Unbound Medicine ER -