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Voltage-gated Sodium Channels in Sensory Information Processing.
CNS Neurol Disord Drug Targets 2019; 18(4):273-278CN

Abstract

Objective &

Background:

Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on.

Conclusion:

This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases.

Authors+Show Affiliations

Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, China.Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, China.Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29952271

Citation

Zhou, You, et al. "Voltage-gated Sodium Channels in Sensory Information Processing." CNS & Neurological Disorders Drug Targets, vol. 18, no. 4, 2019, pp. 273-278.
Zhou Y, Pan P, Tan ZY, et al. Voltage-gated Sodium Channels in Sensory Information Processing. CNS Neurol Disord Drug Targets. 2019;18(4):273-278.
Zhou, Y., Pan, P., Tan, Z. Y., & Ji, Y. H. (2019). Voltage-gated Sodium Channels in Sensory Information Processing. CNS & Neurological Disorders Drug Targets, 18(4), pp. 273-278. doi:10.2174/1871527317666180627114849.
Zhou Y, et al. Voltage-gated Sodium Channels in Sensory Information Processing. CNS Neurol Disord Drug Targets. 2019;18(4):273-278. PubMed PMID: 29952271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltage-gated Sodium Channels in Sensory Information Processing. AU - Zhou,You, AU - Pan,Ping, AU - Tan,Zhi-Yong, AU - Ji,Yong-Hua, PY - 2017/10/30/received PY - 2018/04/04/revised PY - 2018/05/09/accepted PY - 2018/6/29/pubmed PY - 2018/6/29/medline PY - 2018/6/29/entrez KW - Voltage-gated sodium channel KW - action potential KW - information processing KW - membrane KW - pharmacological KW - protein complexes central nervous system. SP - 273 EP - 278 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 18 IS - 4 N2 - Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on. Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/29952271/Voltage-gated_Sodium_Channels_in_Sensory_Information_Processing L2 - http://www.eurekaselect.com/163254/article DB - PRIME DP - Unbound Medicine ER -