Tags

Type your tag names separated by a space and hit enter

Neuronal, astroglial and locomotor injuries in subchronic copper intoxicated rats are repaired by curcumin: A possible link with Parkinson's disease.
Acta Histochem. 2018 Aug; 120(6):542-550.AH

Abstract

We aim herein to assess the neurotoxic effects of subchronic Cu-exposition (0125%) for 6 weeks on dopaminergic and astroglial systems then locomotor activity in rats as well as the probable therapeutic efficiency of curcumin-I (30 mg/kg B.W.). We found that intoxicated rats showed a significant impairment of Tyrosine Hydroxylase (TH) within substantia nigra pars compacta (SNc), ventral tegmental area (VTA) and the striatal outputs together with loss expression of GFAP in these structures. This was linked with an evident decrease in locomotor performance. Co-treatment with curcumin-I inverted these damages and exhibited a significant neuroprotective potential, thus, both TH expression and locomotor performance was reinstated in intoxicated rats. These results prove a profound dopaminergic and astroglial damages following subchronic Cu exposition and new beneficial curative potential of curcumin against subchronic Cu-induced astroglial and dopaminergic neurotoxicity. Consequently, we suggest that Cu neurotoxicity may be strengthened in vivo firstly by attacking and weaking the astroglial system, and curcumin could be prized as a powerful and preventive target for the neurodegenerative diseases related metal element, especially Parkinson's disease.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Abbaoui A
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco.
Gamrani H
Cadi Ayyad University, Faculty of Sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco. Electronic address: gamrani@uca.ac.ma.

MeSH

AnimalsAstrocytesCopperCurcuminMaleParkinson Disease, SecondaryPars CompactaRatsRats, WistarTyrosine 3-MonooxygenaseVentral Tegmental Area

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29954586

Citation

Abbaoui, Abdellatif, and Halima Gamrani. "Neuronal, Astroglial and Locomotor Injuries in Subchronic Copper Intoxicated Rats Are Repaired By Curcumin: a Possible Link With Parkinson's Disease." Acta Histochemica, vol. 120, no. 6, 2018, pp. 542-550.
Abbaoui A, Gamrani H. Neuronal, astroglial and locomotor injuries in subchronic copper intoxicated rats are repaired by curcumin: A possible link with Parkinson's disease. Acta Histochem. 2018;120(6):542-550.
Abbaoui, A., & Gamrani, H. (2018). Neuronal, astroglial and locomotor injuries in subchronic copper intoxicated rats are repaired by curcumin: A possible link with Parkinson's disease. Acta Histochemica, 120(6), 542-550. https://doi.org/10.1016/j.acthis.2018.06.005
Abbaoui A, Gamrani H. Neuronal, Astroglial and Locomotor Injuries in Subchronic Copper Intoxicated Rats Are Repaired By Curcumin: a Possible Link With Parkinson's Disease. Acta Histochem. 2018;120(6):542-550. PubMed PMID: 29954586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuronal, astroglial and locomotor injuries in subchronic copper intoxicated rats are repaired by curcumin: A possible link with Parkinson's disease. AU - Abbaoui,Abdellatif, AU - Gamrani,Halima, Y1 - 2018/06/27/ PY - 2018/04/17/received PY - 2018/06/19/revised PY - 2018/06/21/accepted PY - 2018/6/30/pubmed PY - 2018/11/9/medline PY - 2018/6/30/entrez KW - Astroglial system and GFAP KW - Copper neurotoxicity KW - Curcumin KW - Midbrain and dopamine KW - Parkinson’s disease KW - Wistar rats SP - 542 EP - 550 JF - Acta histochemica JO - Acta Histochem VL - 120 IS - 6 N2 - We aim herein to assess the neurotoxic effects of subchronic Cu-exposition (0125%) for 6 weeks on dopaminergic and astroglial systems then locomotor activity in rats as well as the probable therapeutic efficiency of curcumin-I (30 mg/kg B.W.). We found that intoxicated rats showed a significant impairment of Tyrosine Hydroxylase (TH) within substantia nigra pars compacta (SNc), ventral tegmental area (VTA) and the striatal outputs together with loss expression of GFAP in these structures. This was linked with an evident decrease in locomotor performance. Co-treatment with curcumin-I inverted these damages and exhibited a significant neuroprotective potential, thus, both TH expression and locomotor performance was reinstated in intoxicated rats. These results prove a profound dopaminergic and astroglial damages following subchronic Cu exposition and new beneficial curative potential of curcumin against subchronic Cu-induced astroglial and dopaminergic neurotoxicity. Consequently, we suggest that Cu neurotoxicity may be strengthened in vivo firstly by attacking and weaking the astroglial system, and curcumin could be prized as a powerful and preventive target for the neurodegenerative diseases related metal element, especially Parkinson's disease. SN - 1618-0372 UR - https://www.unboundmedicine.com/medline/citation/29954586/Neuronal_astroglial_and_locomotor_injuries_in_subchronic_copper_intoxicated_rats_are_repaired_by_curcumin:_A_possible_link_with_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -