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Improving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC.
Schizophr Res 2018; 202:203-209SR

Abstract

Deficits in various cognitive processes, such as working memory, are characteristic for schizophrenia, lowering patients' functioning and quality of life. Recent research suggests that transcranial direct stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) may be a potential therapeutic intervention for cognitive deficits in schizophrenia. Here, we examined the effects of online tDCS to the DLPFC on working memory (WM) performance in 40 schizophrenia patients in two separate experiments with a double blind, sham-controlled, cross-over design. Patients underwent single sessions of active and sham tDCS in a randomized order. Stimulation parameters were anode F3, cathode right deltoid muscle, 21 min tDCS duration, 1 mA tDCS in Experiment 1 (N = 20) and 2 mA tDCS in Experiment 2 (N = 20). Primary outcome was the change in WM performance as measured by a verbal n-back paradigm (1- to 3-back). Irrespective of the stimulation intensity, data analysis showed a significant higher WM accuracy during active tDCS than during sham tDCS (p = 0.019), but no main effect of stimulation intensity (p = 0.392). Subsequent separate analyses revealed a significantly improved WM performance only during 1 mA (p = 0.048). TDCS facilitated WM functioning in schizophrenia, with an advantage of 1 mA over 2 mA. Our results support the notion that tDCS may be a potential treatment for cognitive deficits in schizophrenia and emphasize the need for future research on the specific stimulation parameters.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany. Electronic address: irina.papazova@med.uni-muenchen.com.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen.Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen.Department of Psychiatry and Psychotherapy, Klinikum der Universität München, Ludwig-Maximilians-University, Munich, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29954701

Citation

Papazova, Irina, et al. "Improving Working Memory in Schizophrenia: Effects of 1 mA and 2 mA Transcranial Direct Current Stimulation to the Left DLPFC." Schizophrenia Research, vol. 202, 2018, pp. 203-209.
Papazova I, Strube W, Becker B, et al. Improving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC. Schizophr Res. 2018;202:203-209.
Papazova, I., Strube, W., Becker, B., Henning, B., Schwippel, T., Fallgatter, A. J., ... Hasan, A. (2018). Improving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC. Schizophrenia Research, 202, pp. 203-209. doi:10.1016/j.schres.2018.06.032.
Papazova I, et al. Improving Working Memory in Schizophrenia: Effects of 1 mA and 2 mA Transcranial Direct Current Stimulation to the Left DLPFC. Schizophr Res. 2018;202:203-209. PubMed PMID: 29954701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving working memory in schizophrenia: Effects of 1 mA and 2 mA transcranial direct current stimulation to the left DLPFC. AU - Papazova,Irina, AU - Strube,Wolfgang, AU - Becker,Benedikt, AU - Henning,Bettina, AU - Schwippel,Tobias, AU - Fallgatter,Andreas J, AU - Padberg,Frank, AU - Palm,Ulrich, AU - Falkai,Peter, AU - Plewnia,Christian, AU - Hasan,Alkomiet, Y1 - 2018/06/25/ PY - 2017/12/23/received PY - 2018/04/03/revised PY - 2018/06/11/accepted PY - 2018/6/30/pubmed PY - 2019/10/29/medline PY - 2018/6/30/entrez KW - Cognitive load KW - Schizophrenia KW - Stimulation intensity KW - Working memory KW - tDCS SP - 203 EP - 209 JF - Schizophrenia research JO - Schizophr. Res. VL - 202 N2 - Deficits in various cognitive processes, such as working memory, are characteristic for schizophrenia, lowering patients' functioning and quality of life. Recent research suggests that transcranial direct stimulation (tDCS) applied to the dorsolateral prefrontal cortex (DLPFC) may be a potential therapeutic intervention for cognitive deficits in schizophrenia. Here, we examined the effects of online tDCS to the DLPFC on working memory (WM) performance in 40 schizophrenia patients in two separate experiments with a double blind, sham-controlled, cross-over design. Patients underwent single sessions of active and sham tDCS in a randomized order. Stimulation parameters were anode F3, cathode right deltoid muscle, 21 min tDCS duration, 1 mA tDCS in Experiment 1 (N = 20) and 2 mA tDCS in Experiment 2 (N = 20). Primary outcome was the change in WM performance as measured by a verbal n-back paradigm (1- to 3-back). Irrespective of the stimulation intensity, data analysis showed a significant higher WM accuracy during active tDCS than during sham tDCS (p = 0.019), but no main effect of stimulation intensity (p = 0.392). Subsequent separate analyses revealed a significantly improved WM performance only during 1 mA (p = 0.048). TDCS facilitated WM functioning in schizophrenia, with an advantage of 1 mA over 2 mA. Our results support the notion that tDCS may be a potential treatment for cognitive deficits in schizophrenia and emphasize the need for future research on the specific stimulation parameters. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/29954701/Improving_working_memory_in_schizophrenia:_Effects_of_1_mA_and_2_mA_transcranial_direct_current_stimulation_to_the_left_DLPFC_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(18)30366-9 DB - PRIME DP - Unbound Medicine ER -