Tags

Type your tag names separated by a space and hit enter

Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease.
AJNR Am J Neuroradiol. 2018 08; 39(8):1460-1467.AA

Abstract

BACKGROUND AND PURPOSE

Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear. Our aim was to compare the diagnostic value of MR imaging biomarkers of substantia nigra damage for distinguishing patients with Parkinson disease from healthy volunteers.

MATERIALS AND METHODS

Thirty-six patients and 20 healthy volunteers were prospectively included. The MR imaging protocol at 3T included 3D T2-weighted and T1-weighted neuromelanin-sensitive images, diffusion tensor images, and R2* mapping. T2* high-resolution images were also acquired at 7T to evaluate the dorsal nigral hyperintensity sign. Quantitative analysis was performed using ROIs in the substantia nigra drawn manually around the area of high signal intensity on neuromelanin-sensitive images and T2-weighted images. Visual analysis of the substantia nigra neuromelanin-sensitive signal intensity and the dorsolateral nigral hyperintensity on T2* images was performed.

RESULTS

There was a significant decrease in the neuromelanin-sensitive volume and signal intensity in patients with Parkinson disease. There was also a significant decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivity in the neuromelanin-sensitive substantia nigra at 3T and a decrease in substantia nigra volume on T2* images. The combination of substantia nigra volume, signal intensity, and fractional anisotropy in the neuromelanin-sensitive substantia nigra allowed excellent diagnostic accuracy (0.93). Visual assessment of both substantia nigra dorsolateral hyperintensity and neuromelanin-sensitive images had good diagnostic accuracy (0.91 and 0.86, respectively).

CONCLUSIONS

The combination of neuromelanin signal and volume changes with fractional anisotropy measurements in the substantia nigra showed excellent diagnostic accuracy. Moreover, the high diagnostic accuracy of visual assessment of substantia nigra changes using dorsolateral hyperintensity analysis or neuromelanin-sensitive signal changes indicates that these techniques are promising for clinical practice.

Authors+Show Affiliations

From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France nadya.pyatigorskaya@gmail.com. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France. Service de neuroradiologie (N.P., B.M., S.L.).From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France. Service de neuroradiologie (N.P., B.M., S.L.).From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France.From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France.From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France.From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. Clinical Neurology (D.A.), Department of Neuroscience, University of Genoa, Genoa, Italy. Centre d'Investigation Clinique (D.A., M.V.), Hôpital Pitié-Salpêtrière, Paris, France.Département des Maladies du Système Nerveux (C.E., M.V.), Clinique des mouvements anormaux, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France.NeuroSpin (C.P.), Commissariat à l'Energie Atomique, Gif-Sur-Yvette, France.From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France. Département des Maladies du Système Nerveux (C.E., M.V.), Clinique des mouvements anormaux, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France. Centre d'Investigation Clinique (D.A., M.V.), Hôpital Pitié-Salpêtrière, Paris, France.From the Institut du Cerveau et de la Moelle épinière (N.P., B.M., M.M., L.Y.-C., R.V., D.A., M.V., S.L.), Centre de NeuroImagerie de Recherche, Paris, France. UMR S 1127, CNRS UMR 7225 (N.P., B.M., M.M., L.Y.-C., M.V., S.L.), Sorbonne University, Paris, France. Service de neuroradiologie (N.P., B.M., S.L.).

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29954816

Citation

Pyatigorskaya, N, et al. "Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease." AJNR. American Journal of Neuroradiology, vol. 39, no. 8, 2018, pp. 1460-1467.
Pyatigorskaya N, Magnin B, Mongin M, et al. Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease. AJNR Am J Neuroradiol. 2018;39(8):1460-1467.
Pyatigorskaya, N., Magnin, B., Mongin, M., Yahia-Cherif, L., Valabregue, R., Arnaldi, D., Ewenczyk, C., Poupon, C., Vidailhet, M., & Lehéricy, S. (2018). Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease. AJNR. American Journal of Neuroradiology, 39(8), 1460-1467. https://doi.org/10.3174/ajnr.A5702
Pyatigorskaya N, et al. Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease. AJNR Am J Neuroradiol. 2018;39(8):1460-1467. PubMed PMID: 29954816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Study of MRI Biomarkers in the Substantia Nigra to Discriminate Idiopathic Parkinson Disease. AU - Pyatigorskaya,N, AU - Magnin,B, AU - Mongin,M, AU - Yahia-Cherif,L, AU - Valabregue,R, AU - Arnaldi,D, AU - Ewenczyk,C, AU - Poupon,C, AU - Vidailhet,M, AU - Lehéricy,S, Y1 - 2018/06/28/ PY - 2018/01/10/received PY - 2018/04/29/accepted PY - 2018/6/30/pubmed PY - 2019/10/3/medline PY - 2018/6/30/entrez SP - 1460 EP - 1467 JF - AJNR. American journal of neuroradiology JO - AJNR Am J Neuroradiol VL - 39 IS - 8 N2 - BACKGROUND AND PURPOSE: Several new MR imaging techniques have shown promising results in patients with Parkinson disease; however, the comparative diagnostic values of these measures at the individual level remain unclear. Our aim was to compare the diagnostic value of MR imaging biomarkers of substantia nigra damage for distinguishing patients with Parkinson disease from healthy volunteers. MATERIALS AND METHODS: Thirty-six patients and 20 healthy volunteers were prospectively included. The MR imaging protocol at 3T included 3D T2-weighted and T1-weighted neuromelanin-sensitive images, diffusion tensor images, and R2* mapping. T2* high-resolution images were also acquired at 7T to evaluate the dorsal nigral hyperintensity sign. Quantitative analysis was performed using ROIs in the substantia nigra drawn manually around the area of high signal intensity on neuromelanin-sensitive images and T2-weighted images. Visual analysis of the substantia nigra neuromelanin-sensitive signal intensity and the dorsolateral nigral hyperintensity on T2* images was performed. RESULTS: There was a significant decrease in the neuromelanin-sensitive volume and signal intensity in patients with Parkinson disease. There was also a significant decrease in fractional anisotropy and an increase in mean, axial, and radial diffusivity in the neuromelanin-sensitive substantia nigra at 3T and a decrease in substantia nigra volume on T2* images. The combination of substantia nigra volume, signal intensity, and fractional anisotropy in the neuromelanin-sensitive substantia nigra allowed excellent diagnostic accuracy (0.93). Visual assessment of both substantia nigra dorsolateral hyperintensity and neuromelanin-sensitive images had good diagnostic accuracy (0.91 and 0.86, respectively). CONCLUSIONS: The combination of neuromelanin signal and volume changes with fractional anisotropy measurements in the substantia nigra showed excellent diagnostic accuracy. Moreover, the high diagnostic accuracy of visual assessment of substantia nigra changes using dorsolateral hyperintensity analysis or neuromelanin-sensitive signal changes indicates that these techniques are promising for clinical practice. SN - 1936-959X UR - https://www.unboundmedicine.com/medline/citation/29954816/Comparative_Study_of_MRI_Biomarkers_in_the_Substantia_Nigra_to_Discriminate_Idiopathic_Parkinson_Disease_ L2 - http://www.ajnr.org/cgi/pmidlookup?view=long&pmid=29954816 DB - PRIME DP - Unbound Medicine ER -