Tags

Type your tag names separated by a space and hit enter

Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women.
J Bone Miner Metab. 2019 Mar; 37(2):358-367.JB

Abstract

Whole-body vibration (WBV) has been shown to improve bone mineral density, and muscle strength and power. No studies to date have examined sclerostin and parathyroid hormone (PTH) responses to WBV combined with resistance exercise (RE). This randomized crossover study compared acute serum sclerostin and PTH responses to RE and WBV + RE in young women (n = 9) taking oral contraceptives. Participants were exposed to 5 1-min bouts of vibration (20 Hz, 3.38 peak-peak displacement, separated by 1 min of rest) before high intensity resistance exercise. Fasting blood samples were obtained before (PRE), immediately after WBV (POSTWBV), immediately post RE (IP) and 30 min post RE (30P). Pre-exercise sclerostin and PTH levels were not significantly different between conditions. Sclerostin levels significantly (p < 0.05) increased from PRE to IP for the WBV + RE condition, then decreased back to the pre-exercise level. PTH significantly decreased from PRE to 30P (p < 0.05) and IP to 30P (p < 0.01) for both conditions. Correcting for hemoconcentration eliminated the significant sclerostin responses, but the significant decrease in PTH remained (p < 0.05). There were no significant relationships found between sclerostin and PTH. In conclusion, sclerostin concentrations increased in response to the WBV + RE condition, which may have been mediated by plasma volume shifts. There was no transient PTH increase, but it showed a large decrease at 30P for both conditions. Based on these findings, the addition of WBV exposures prior to high intensity RE did not alter sclerostin and PTH responses to RE in young women.

Authors+Show Affiliations

Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA.Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA.Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO, 80045, USA.Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA.Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA. dbemben@ou.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29956019

Citation

Sharma-Ghimire, Pragya, et al. "Sclerostin and Parathyroid Hormone Responses to Acute Whole-body Vibration and Resistance Exercise in Young Women." Journal of Bone and Mineral Metabolism, vol. 37, no. 2, 2019, pp. 358-367.
Sharma-Ghimire P, Chen Z, Sherk V, et al. Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women. J Bone Miner Metab. 2019;37(2):358-367.
Sharma-Ghimire, P., Chen, Z., Sherk, V., Bemben, M., & Bemben, D. (2019). Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women. Journal of Bone and Mineral Metabolism, 37(2), 358-367. https://doi.org/10.1007/s00774-018-0933-0
Sharma-Ghimire P, et al. Sclerostin and Parathyroid Hormone Responses to Acute Whole-body Vibration and Resistance Exercise in Young Women. J Bone Miner Metab. 2019;37(2):358-367. PubMed PMID: 29956019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women. AU - Sharma-Ghimire,Pragya, AU - Chen,Zhaojing, AU - Sherk,Vanessa, AU - Bemben,Michael, AU - Bemben,Debra, Y1 - 2018/06/28/ PY - 2017/10/24/received PY - 2018/04/29/accepted PY - 2018/6/30/pubmed PY - 2019/5/7/medline PY - 2018/6/30/entrez KW - Bone turnover markers KW - Mechanical loading KW - Resistance exercise KW - Vibration SP - 358 EP - 367 JF - Journal of bone and mineral metabolism JO - J Bone Miner Metab VL - 37 IS - 2 N2 - Whole-body vibration (WBV) has been shown to improve bone mineral density, and muscle strength and power. No studies to date have examined sclerostin and parathyroid hormone (PTH) responses to WBV combined with resistance exercise (RE). This randomized crossover study compared acute serum sclerostin and PTH responses to RE and WBV + RE in young women (n = 9) taking oral contraceptives. Participants were exposed to 5 1-min bouts of vibration (20 Hz, 3.38 peak-peak displacement, separated by 1 min of rest) before high intensity resistance exercise. Fasting blood samples were obtained before (PRE), immediately after WBV (POSTWBV), immediately post RE (IP) and 30 min post RE (30P). Pre-exercise sclerostin and PTH levels were not significantly different between conditions. Sclerostin levels significantly (p < 0.05) increased from PRE to IP for the WBV + RE condition, then decreased back to the pre-exercise level. PTH significantly decreased from PRE to 30P (p < 0.05) and IP to 30P (p < 0.01) for both conditions. Correcting for hemoconcentration eliminated the significant sclerostin responses, but the significant decrease in PTH remained (p < 0.05). There were no significant relationships found between sclerostin and PTH. In conclusion, sclerostin concentrations increased in response to the WBV + RE condition, which may have been mediated by plasma volume shifts. There was no transient PTH increase, but it showed a large decrease at 30P for both conditions. Based on these findings, the addition of WBV exposures prior to high intensity RE did not alter sclerostin and PTH responses to RE in young women. SN - 1435-5604 UR - https://www.unboundmedicine.com/medline/citation/29956019/Sclerostin_and_parathyroid_hormone_responses_to_acute_whole_body_vibration_and_resistance_exercise_in_young_women_ L2 - https://dx.doi.org/10.1007/s00774-018-0933-0 DB - PRIME DP - Unbound Medicine ER -