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Persistent hypoglycemia associated with lipid storage myopathy in a paint foal.
J Vet Intern Med. 2018 Jul; 32(4):1442-1446.JV

Abstract

A 12-hours-old Paint filly was examined because of weakness and dull mentation after birth. Despite IV administered dextrose, the foal remained persistently hypoglycemic with increase in serum activity of muscle and liver enzymes. A postmortem diagnosis of lipid myopathy most similar to multiple acyl-CoA dehydrogenase deficiency (MADD) was confirmed by findings of myofiber lipid accumulation, elevated urine organic acids, and serum free acylcarnitines with respect to control foals. This report details a case of equine neonatal lipid storage myopathy with many biochemical characteristics of MADD. Lipid storage myopathies should be included as a differential diagnosis in foals with persistent weakness and hypoglycemia.

Authors+Show Affiliations

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York.Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York.Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York.Veterinary Practice, Boyds, Maryland.Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York.Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

29957835

Citation

Pinn, Toby L., et al. "Persistent Hypoglycemia Associated With Lipid Storage Myopathy in a Paint Foal." Journal of Veterinary Internal Medicine, vol. 32, no. 4, 2018, pp. 1442-1446.
Pinn TL, Divers TJ, Southard T, et al. Persistent hypoglycemia associated with lipid storage myopathy in a paint foal. J Vet Intern Med. 2018;32(4):1442-1446.
Pinn, T. L., Divers, T. J., Southard, T., De Bernardis, N. P., Wakshlag, J. J., & Valberg, S. (2018). Persistent hypoglycemia associated with lipid storage myopathy in a paint foal. Journal of Veterinary Internal Medicine, 32(4), 1442-1446. https://doi.org/10.1111/jvim.15218
Pinn TL, et al. Persistent Hypoglycemia Associated With Lipid Storage Myopathy in a Paint Foal. J Vet Intern Med. 2018;32(4):1442-1446. PubMed PMID: 29957835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent hypoglycemia associated with lipid storage myopathy in a paint foal. AU - Pinn,Toby L, AU - Divers,Thomas J, AU - Southard,Teresa, AU - De Bernardis,Nikhita P, AU - Wakshlag,Joe J, AU - Valberg,Stephanie, Y1 - 2018/06/29/ PY - 2017/11/18/received PY - 2018/02/15/revised PY - 2018/04/24/accepted PY - 2018/6/30/pubmed PY - 2018/11/27/medline PY - 2018/6/30/entrez KW - beta oxidation KW - horse KW - metabolic KW - weakness SP - 1442 EP - 1446 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 32 IS - 4 N2 - A 12-hours-old Paint filly was examined because of weakness and dull mentation after birth. Despite IV administered dextrose, the foal remained persistently hypoglycemic with increase in serum activity of muscle and liver enzymes. A postmortem diagnosis of lipid myopathy most similar to multiple acyl-CoA dehydrogenase deficiency (MADD) was confirmed by findings of myofiber lipid accumulation, elevated urine organic acids, and serum free acylcarnitines with respect to control foals. This report details a case of equine neonatal lipid storage myopathy with many biochemical characteristics of MADD. Lipid storage myopathies should be included as a differential diagnosis in foals with persistent weakness and hypoglycemia. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/29957835/Persistent_hypoglycemia_associated_with_lipid_storage_myopathy_in_a_paint_foal_ L2 - https://doi.org/10.1111/jvim.15218 DB - PRIME DP - Unbound Medicine ER -