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Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice.
J Tradit Chin Med. 2017 02; 37(1):96-100.JT

Abstract

OBJECTIVE

To investigate the effects of electroacupuncture (EA) at the Guanyuan (CV 4) or Sanyinjiao (SP 6) acupoints on the hypothalamus-pituitary-ovary (HPO) axis and spatial learning and memory in female mice.

METHODS

Nine-month-old female mice with senescence-accelerated mouse prone 8 (SAMP8) were divided into three groups: the disease model, EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1 (SAMR1) were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone (FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determine the HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze (MWM) test.

RESULTS

(a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels (P < 0.01), and an increase in GnRH, LH and FSH levels (P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group (P < 0.05). In contrast, GnRH and LH and FSH levels were reduced (P < 0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining GnRH levels (P < 0.01). (b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day 5 compared with the disease model group (P < 0.05), whereas the EA-Guanyuan treatment group showed no significant difference.

CONCLUSION

EA can regulate hormone (E2, FSH, LH, GnRH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

29957916

Citation

Wang, Jing, et al. "Effects of Electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) On Hypothalamus-pituitary-ovary Axis and Spatial Learning and Memory in Female SAMP8 Mice." Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan, vol. 37, no. 1, 2017, pp. 96-100.
Wang J, Cheng K, Qin Z, et al. Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice. J Tradit Chin Med. 2017;37(1):96-100.
Wang, J., Cheng, K., Qin, Z., Wang, Y., Zhai, L., You, M., & Wu, J. (2017). Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice. Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan, 37(1), 96-100.
Wang J, et al. Effects of Electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) On Hypothalamus-pituitary-ovary Axis and Spatial Learning and Memory in Female SAMP8 Mice. J Tradit Chin Med. 2017;37(1):96-100. PubMed PMID: 29957916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of electroacupuncture at Guanyuan (CV 4) or Sanyinjiao (SP 6) on hypothalamus-pituitary-ovary axis and spatial learning and memory in female SAMP8 mice. AU - Wang,Jing, AU - Cheng,Kai, AU - Qin,Zhuo, AU - Wang,Yanping, AU - Zhai,Lijing, AU - You,Min, AU - Wu,Juanjiao, PY - 2018/6/30/entrez PY - 2017/2/1/pubmed PY - 2018/8/1/medline SP - 96 EP - 100 JF - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan JO - J Tradit Chin Med VL - 37 IS - 1 N2 - OBJECTIVE: To investigate the effects of electroacupuncture (EA) at the Guanyuan (CV 4) or Sanyinjiao (SP 6) acupoints on the hypothalamus-pituitary-ovary (HPO) axis and spatial learning and memory in female mice. METHODS: Nine-month-old female mice with senescence-accelerated mouse prone 8 (SAMP8) were divided into three groups: the disease model, EA-Guanyuan and EA-Sanyinjiao groups. Concurrently, 9-month old female mice with senescence-accelerated mouse resistance 1 (SAMR1) were set as the control model group. The two treatment groups were given the same pattern of EA stimulation. Gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone (FSH) and Serum estradiol levels in the Hypothalamus-pituitary-ovary axis were assessed by enzyme-linked immunosorbent assay to determine the HPO axis function level. Spatial learning and memory were assessed by the Morris Water Maze (MWM) test. RESULTS: (a) HPO axis: compared with the control model group, the disease model group displayed a decrease in E2 levels (P < 0.01), and an increase in GnRH, LH and FSH levels (P < 0.01). E2 levels were increased in EA treatment groups compared with the disease model group (P < 0.05). In contrast, GnRH and LH and FSH levels were reduced (P < 0.05). EA-Sanyinjiao group was superior than EA-Guanyuan group on increasing E2 and declining GnRH levels (P < 0.01). (b) The MWM test demonstrated that the response latency in the EA-Sanyinjiao treatment group declined from day 2 to day 5 compared with the disease model group (P < 0.05), whereas the EA-Guanyuan treatment group showed no significant difference. CONCLUSION: EA can regulate hormone (E2, FSH, LH, GnRH) levels in the HPO axis and the spatial learning and memory ability in female SAMP8 mice. Moreover, this effect may have been more pronounced in the EA-Sanyinjiao group than the EA-Guanyuan group. The underlying mechanism of the EA-induced changes may be related to gonadal hormone shifts in the HPO axis, followed by an improvement in spatial learning and memory. SN - 0255-2922 UR - https://www.unboundmedicine.com/medline/citation/29957916/Effects_of_electroacupuncture_at_Guanyuan__CV_4__or_Sanyinjiao__SP_6__on_hypothalamus_pituitary_ovary_axis_and_spatial_learning_and_memory_in_female_SAMP8_mice_ L2 - http://www.journaltcm.com/index.php?module=Journal&amp;func=downloadFullContent&amp;sid=2640 DB - PRIME DP - Unbound Medicine ER -