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Carotid artery wall mechanics in young males with high cardiorespiratory fitness.
Exp Physiol. 2018 09; 103(9):1277-1286.EP

Abstract

NEW FINDINGS

What is the central question of this study? Common carotid artery (CCA) two-dimensional strain imaging detects intrinsic arterial wall properties beyond conventional measures of arterial stiffness, but the effect of cardiorespiratory fitness on two-dimensional strain-derived indices of CCA stiffness is unknown. What is the main finding and its importance? Two-dimensional strain imaging of the CCA revealed greater peak circumferential strain and systolic strain rate in highly fit men compared with their less fit counterparts. Altered CCA wall mechanics might reflect intrinsic training-induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise.

ABSTRACT

The influence of cardiorespiratory fitness on arterial stiffness in young adults remains equivocal. Beyond conventional measures of arterial stiffness, two-dimensional strain imaging of the common carotid artery (CCA) provides new information related to the intrinsic properties of the arterial wall. Therefore, the aim of this study was to assess the effect of cardiorespiratory fitness on both conventional indices of CCA stiffness and two-dimensional strain parameters, at rest and after a bout of aerobic exercise in young, healthy men. Short-axis ultrasound images of the CCA were recorded in 34 healthy men {22 years old [95% confidence interval (CI), 19, 22]} before and immediately after 5 min of aerobic exercise (40% of maximal oxygen consumption). Images were analysed for arterial diameter, peak circumferential strain (PCS) and peak systolic and diastolic strain rates (S-SR and D-SR). Heart rate, systolic and diastolic blood pressure were simultaneously assessed, and Peterson's elastic modulus (Ep) and β-stiffness (β1) were calculated. Participants were separated post hoc into moderate- and high-fitness groups [maximal oxygen consumption, 48.9 (95% CI, 44.7, 53.2) versus 65.6 ml kg-1 min-1 (95% CI, 63.1, 68.1), respectively; P < 0.001]. The Ep and β1 were similar between groups at baseline (P > 0.13) but were elevated in the moderate-fitness group postexercise (P < 0.04). The PCS and S-SR were elevated in the high-fitness group at both time points [3.0% (95% CI, 1.2, 4.9), P = 0.002, and 0.401 s-1 (95% CI, 0.085, 0.72), P = 0.02, respectively]. No group differences were observed in CCA heart rate, systolic or diastolic blood pressure or D-SR throughout the protocol (P > 0.05). Highly fit individuals exhibit elevated CCA, PCS and S-SR, which might reflect training-induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise.

Authors+Show Affiliations

Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK. School of Sport & Exercise, University of Gloucester, Gloucester, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK. Columbia University Irving Medical Center, Columbia University in the City of New York, New York, NY, USA.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK.Cardiff School of Sport & Health Science, Cardiff Metropolitan University, Cardiff, UK. Centre for Heart, Lung & Vascular Health, University of British Columbia, Kelowna, BC, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29959801

Citation

Pugh, Christopher J A., et al. "Carotid Artery Wall Mechanics in Young Males With High Cardiorespiratory Fitness." Experimental Physiology, vol. 103, no. 9, 2018, pp. 1277-1286.
Pugh CJA, Stone KJ, Stöhr EJ, et al. Carotid artery wall mechanics in young males with high cardiorespiratory fitness. Exp Physiol. 2018;103(9):1277-1286.
Pugh, C. J. A., Stone, K. J., Stöhr, E. J., McDonnell, B. J., Thompson, J. E. S., Talbot, J. S., Wakeham, D. J., Cockcroft, J. R., & Shave, R. (2018). Carotid artery wall mechanics in young males with high cardiorespiratory fitness. Experimental Physiology, 103(9), 1277-1286. https://doi.org/10.1113/EP087067
Pugh CJA, et al. Carotid Artery Wall Mechanics in Young Males With High Cardiorespiratory Fitness. Exp Physiol. 2018;103(9):1277-1286. PubMed PMID: 29959801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid artery wall mechanics in young males with high cardiorespiratory fitness. AU - Pugh,Christopher J A, AU - Stone,Keeron J, AU - Stöhr,Eric J, AU - McDonnell,Barry J, AU - Thompson,Jane E S, AU - Talbot,Jack S, AU - Wakeham,Denis J, AU - Cockcroft,John R, AU - Shave,Robert, Y1 - 2018/08/01/ PY - 2018/04/18/received PY - 2018/06/28/accepted PY - 2018/7/1/pubmed PY - 2019/5/30/medline PY - 2018/7/1/entrez KW - cardiorespiratory fitness KW - carotid artery stiffness KW - exercise KW - two-dimensional strain imaging SP - 1277 EP - 1286 JF - Experimental physiology JO - Exp. Physiol. VL - 103 IS - 9 N2 - NEW FINDINGS: What is the central question of this study? Common carotid artery (CCA) two-dimensional strain imaging detects intrinsic arterial wall properties beyond conventional measures of arterial stiffness, but the effect of cardiorespiratory fitness on two-dimensional strain-derived indices of CCA stiffness is unknown. What is the main finding and its importance? Two-dimensional strain imaging of the CCA revealed greater peak circumferential strain and systolic strain rate in highly fit men compared with their less fit counterparts. Altered CCA wall mechanics might reflect intrinsic training-induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise. ABSTRACT: The influence of cardiorespiratory fitness on arterial stiffness in young adults remains equivocal. Beyond conventional measures of arterial stiffness, two-dimensional strain imaging of the common carotid artery (CCA) provides new information related to the intrinsic properties of the arterial wall. Therefore, the aim of this study was to assess the effect of cardiorespiratory fitness on both conventional indices of CCA stiffness and two-dimensional strain parameters, at rest and after a bout of aerobic exercise in young, healthy men. Short-axis ultrasound images of the CCA were recorded in 34 healthy men {22 years old [95% confidence interval (CI), 19, 22]} before and immediately after 5 min of aerobic exercise (40% of maximal oxygen consumption). Images were analysed for arterial diameter, peak circumferential strain (PCS) and peak systolic and diastolic strain rates (S-SR and D-SR). Heart rate, systolic and diastolic blood pressure were simultaneously assessed, and Peterson's elastic modulus (Ep) and β-stiffness (β1) were calculated. Participants were separated post hoc into moderate- and high-fitness groups [maximal oxygen consumption, 48.9 (95% CI, 44.7, 53.2) versus 65.6 ml kg-1 min-1 (95% CI, 63.1, 68.1), respectively; P < 0.001]. The Ep and β1 were similar between groups at baseline (P > 0.13) but were elevated in the moderate-fitness group postexercise (P < 0.04). The PCS and S-SR were elevated in the high-fitness group at both time points [3.0% (95% CI, 1.2, 4.9), P = 0.002, and 0.401 s-1 (95% CI, 0.085, 0.72), P = 0.02, respectively]. No group differences were observed in CCA heart rate, systolic or diastolic blood pressure or D-SR throughout the protocol (P > 0.05). Highly fit individuals exhibit elevated CCA, PCS and S-SR, which might reflect training-induced adaptations that help to buffer the increase in pulse pressure and stroke volume during exercise. SN - 1469-445X UR - https://www.unboundmedicine.com/medline/citation/29959801/Carotid_artery_wall_mechanics_in_young_males_with_high_cardiorespiratory_fitness_ L2 - https://doi.org/10.1113/EP087067 DB - PRIME DP - Unbound Medicine ER -