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High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis.
J Sex Med 2018; 15(7):935-941JS

Abstract

BACKGROUND

Erectile dysfunction (ED) may be common among diabetic men with depressive symptoms (DS), but its prevalence is still debated.

AIM

To conduct a meta-analysis of the prevalence of ED in diabetic men with DS compared to those without DS, calculating the relative odds ratios (ORs) and 95% CIs.

METHODS

PubMed, MEDLINE, Embase, and Web of Science were searched up to January 2018. All the studies assessing the risk of ED among diabetic men having DS were reviewed. 2 Authors independently assessed literature and extracted information eligibility. Any disagreement was resolved by a third reviewer. Newcastle-Ottawa quality assessment scale was used to evaluate study quality in meta-analyses. We calculated the ORs with 95% CIs using software Stata, Version 12.0; StataCorp, College Station, TX). Data were pooled using a fixed or random effects model according to heterogeneity. Sensitivity analyses were conducted to assess potential bias. This study was conducted according to the guidelines for Meta-Analyses and Systematic Reviews of Observational Studies.

OUTCOMES

The strength of the association between DS and the prevalence of ED was evaluated using ORs and 95% CIs.

RESULTS

5 Studies were eligible for the present analysis, reporting on a total of 2525 diabetic men. Mean age of patients ranged from 42.37-61.65 years in the included studies. The overall prevalence of ED in diabetic men with DS was 74.2% (95% CI 59.0-89.4). The overall prevalence of ED in diabetic men without DS was 37.4% (95% CI 16.2-58.6). The pooled crude OR for these 5 studies was 6.40 (95% CI 2.11-19.38, P < .05, I2 = 94.6%). The pooled OR of 4 multi-variate analyses was 3.08 (95% CI 1.32-4.85, P < .001, I2 = 83.5%).

CLINICAL IMPLICATIONS

Diabetic men with DS had a significantly increased prevalence of ED, suggesting that ED should be of concern to clinicians when managing diabetic men with DS.

STRENGTHS & LIMITATIONS

A strength of this study is that it is the first meta-analysis to assess the prevalence of ED in diabetic men with DS and quantitatively analyze the association between DS and ED risk among diabetic men. A limitation is that all included studies were cross-sectional studies, which may generate bias.

CONCLUSION

The present meta-analysis of 5 cross-sectional studies suggests that diabetic men showing DS, compared to the diabetic men without DS, have more risk of ED. Further larger prospective cohorts with more power or meta-analysis based on individual patient data need to be conducted to confirm this association. Wang X, Yang X, Cai Y, et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. J Sex Med 2018;15:935-941.

Authors+Show Affiliations

Department of Nursing, Affiliated Haian Hospital of Nantong University, Nantong, China.Department of Endocrinology, Affiliated Haian Hospital of Nantong University, Nantong, China.Department of Nursing, Affiliated Haian Hospital of Nantong University, Nantong, China.Department of Nursing, Affiliated Haian Hospital of Nantong University, Nantong, China.Department of Nursing, Second Affiliated Hospital of Nantong University, Nantong, China. Electronic address: wengweiqun011@163.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29960629

Citation

Wang, Xu, et al. "High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: a Meta-Analysis." The Journal of Sexual Medicine, vol. 15, no. 7, 2018, pp. 935-941.
Wang X, Yang X, Cai Y, et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. J Sex Med. 2018;15(7):935-941.
Wang, X., Yang, X., Cai, Y., Wang, S., & Weng, W. (2018). High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. The Journal of Sexual Medicine, 15(7), pp. 935-941. doi:10.1016/j.jsxm.2018.05.007.
Wang X, et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: a Meta-Analysis. J Sex Med. 2018;15(7):935-941. PubMed PMID: 29960629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. AU - Wang,Xu, AU - Yang,Xiaohua, AU - Cai,Yihong, AU - Wang,Shengmei, AU - Weng,Weiqun, PY - 2018/01/25/received PY - 2018/05/25/revised PY - 2018/05/26/accepted PY - 2018/7/2/entrez PY - 2018/7/2/pubmed PY - 2018/7/2/medline KW - Depressive Symptoms KW - Diabetes KW - Erectile Dysfunction KW - Men SP - 935 EP - 941 JF - The journal of sexual medicine JO - J Sex Med VL - 15 IS - 7 N2 - BACKGROUND: Erectile dysfunction (ED) may be common among diabetic men with depressive symptoms (DS), but its prevalence is still debated. AIM: To conduct a meta-analysis of the prevalence of ED in diabetic men with DS compared to those without DS, calculating the relative odds ratios (ORs) and 95% CIs. METHODS: PubMed, MEDLINE, Embase, and Web of Science were searched up to January 2018. All the studies assessing the risk of ED among diabetic men having DS were reviewed. 2 Authors independently assessed literature and extracted information eligibility. Any disagreement was resolved by a third reviewer. Newcastle-Ottawa quality assessment scale was used to evaluate study quality in meta-analyses. We calculated the ORs with 95% CIs using software Stata, Version 12.0; StataCorp, College Station, TX). Data were pooled using a fixed or random effects model according to heterogeneity. Sensitivity analyses were conducted to assess potential bias. This study was conducted according to the guidelines for Meta-Analyses and Systematic Reviews of Observational Studies. OUTCOMES: The strength of the association between DS and the prevalence of ED was evaluated using ORs and 95% CIs. RESULTS: 5 Studies were eligible for the present analysis, reporting on a total of 2525 diabetic men. Mean age of patients ranged from 42.37-61.65 years in the included studies. The overall prevalence of ED in diabetic men with DS was 74.2% (95% CI 59.0-89.4). The overall prevalence of ED in diabetic men without DS was 37.4% (95% CI 16.2-58.6). The pooled crude OR for these 5 studies was 6.40 (95% CI 2.11-19.38, P < .05, I2 = 94.6%). The pooled OR of 4 multi-variate analyses was 3.08 (95% CI 1.32-4.85, P < .001, I2 = 83.5%). CLINICAL IMPLICATIONS: Diabetic men with DS had a significantly increased prevalence of ED, suggesting that ED should be of concern to clinicians when managing diabetic men with DS. STRENGTHS & LIMITATIONS: A strength of this study is that it is the first meta-analysis to assess the prevalence of ED in diabetic men with DS and quantitatively analyze the association between DS and ED risk among diabetic men. A limitation is that all included studies were cross-sectional studies, which may generate bias. CONCLUSION: The present meta-analysis of 5 cross-sectional studies suggests that diabetic men showing DS, compared to the diabetic men without DS, have more risk of ED. Further larger prospective cohorts with more power or meta-analysis based on individual patient data need to be conducted to confirm this association. Wang X, Yang X, Cai Y, et al. High Prevalence of Erectile Dysfunction in Diabetic Men With Depressive Symptoms: A Meta-Analysis. J Sex Med 2018;15:935-941. SN - 1743-6109 UR - https://www.unboundmedicine.com/medline/citation/29960629/High_Prevalence_of_Erectile_Dysfunction_in_Diabetic_Men_With_Depressive_Symptoms:_A_Meta_Analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1743-6095(18)30997-4 DB - PRIME DP - Unbound Medicine ER -