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Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat.
Scand J Gastroenterol. 1985 Sep; 20(7):887-95.SJ

Abstract

The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): ACO fibre tablets (barley and citrus pulp), 451; Fiberform (wheat bran-based), 817; Inolaxol (sterkulia gum), 696; and Vi-Siblin (ispaghula husk), 533. The increase in faecal dry matter per 1 g dietary fibre was similar with ACO fibre tablets, Fiberform, and Vi-Siblin. Inolaxol gave a significantly (p less than 0.001) higher faecal dry-weight increment, mainly due to an increased mineral excretion. Of the dry-weight increment, 59-82% constituted undegraded dietary fibre. Thus, 68-97% of the fibre passed through the gastrointestinal tract without being degraded. All the bulk laxatives caused a similar increase in the faecal N content, whereas the increase in faecal lipids was most pronounced with Vi-Siblin. The water-holding capacity of faeces was more pronounced with Inolaxol and Vi-Siblin than with ACO fibre tablets and Fiberform.

Authors

Nyman M
No affiliation info available
Asp NG
No affiliation info available

MeSH

AnimalsCatharticsDietary FiberIntestinal MucosaLipid MetabolismMineralsMolecular ConformationMolecular WeightNitrogenRatsSolubilityTechnology, Pharmaceutical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2996120

Citation

Nyman, M, and N G. Asp. "Bulk Laxatives: Their Dietary Fibre Composition, Degradation, and Faecal Bulking Capacity in the Rat." Scandinavian Journal of Gastroenterology, vol. 20, no. 7, 1985, pp. 887-95.
Nyman M, Asp NG. Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat. Scand J Gastroenterol. 1985;20(7):887-95.
Nyman, M., & Asp, N. G. (1985). Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat. Scandinavian Journal of Gastroenterology, 20(7), 887-95.
Nyman M, Asp NG. Bulk Laxatives: Their Dietary Fibre Composition, Degradation, and Faecal Bulking Capacity in the Rat. Scand J Gastroenterol. 1985;20(7):887-95. PubMed PMID: 2996120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bulk laxatives: their dietary fibre composition, degradation, and faecal bulking capacity in the rat. AU - Nyman,M, AU - Asp,N G, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 887 EP - 95 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 20 IS - 7 N2 - The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): ACO fibre tablets (barley and citrus pulp), 451; Fiberform (wheat bran-based), 817; Inolaxol (sterkulia gum), 696; and Vi-Siblin (ispaghula husk), 533. The increase in faecal dry matter per 1 g dietary fibre was similar with ACO fibre tablets, Fiberform, and Vi-Siblin. Inolaxol gave a significantly (p less than 0.001) higher faecal dry-weight increment, mainly due to an increased mineral excretion. Of the dry-weight increment, 59-82% constituted undegraded dietary fibre. Thus, 68-97% of the fibre passed through the gastrointestinal tract without being degraded. All the bulk laxatives caused a similar increase in the faecal N content, whereas the increase in faecal lipids was most pronounced with Vi-Siblin. The water-holding capacity of faeces was more pronounced with Inolaxol and Vi-Siblin than with ACO fibre tablets and Fiberform. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/2996120/Bulk_laxatives:_their_dietary_fibre_composition_degradation_and_faecal_bulking_capacity_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -