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Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border.
J Infect 2018; 77(5):435-439JI

Abstract

OBJECTIVES

Hemoglobin E (HbE, β26 Glu-Lys) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia.

METHODS

In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers.

RESULTS

HbE in P. vivax patients (17.4%) was significantly less prevalent than in the healthy villager population (36.3%). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5% prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities.

CONCLUSIONS

HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population.

Authors+Show Affiliations

Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China.Department of Histology and Embryology, Kunming Medical University, Kunming, Yunnan Province, China.Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, China.Department of Cell Biology and Medical Genetics, Kunming Medical University, Kunming, Yunnan Province, China. Electronic address: yongshuhe@hotmail.com.Department of Entomology, The Pennsylvania State University, Pennsylvania, United States of America. Electronic address: luc2@psu.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29964138

Citation

Deng, Zeshuai, et al. "Hemoglobin E Protects Against Acute Plasmodium Vivax Infections in a Kachin Population at the China-Myanmar Border." The Journal of Infection, vol. 77, no. 5, 2018, pp. 435-439.
Deng Z, Li Q, Yi H, et al. Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border. J Infect. 2018;77(5):435-439.
Deng, Z., Li, Q., Yi, H., Zhang, Y., Yang, F., Li, H., ... Cui, L. (2018). Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border. The Journal of Infection, 77(5), pp. 435-439. doi:10.1016/j.jinf.2018.06.005.
Deng Z, et al. Hemoglobin E Protects Against Acute Plasmodium Vivax Infections in a Kachin Population at the China-Myanmar Border. J Infect. 2018;77(5):435-439. PubMed PMID: 29964138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border. AU - Deng,Zeshuai, AU - Li,Qing, AU - Yi,Haoan, AU - Zhang,Yanjie, AU - Yang,Fang, AU - Li,Hong, AU - Luo,Lan, AU - Ma,Limei, AU - Yang,Zhaoqing, AU - He,Yongshu, AU - Cui,Liwang, Y1 - 2018/06/28/ PY - 2018/04/24/received PY - 2018/06/17/revised PY - 2018/06/19/accepted PY - 2018/7/3/pubmed PY - 2019/9/29/medline PY - 2018/7/3/entrez KW - Hemoglobin E KW - Hemogloinopathy KW - Malaria hypothesis KW - Plasmodium vivax KW - Protection SP - 435 EP - 439 JF - The Journal of infection JO - J. Infect. VL - 77 IS - 5 N2 - OBJECTIVES: Hemoglobin E (HbE, β26 Glu-Lys) is the most prevalent hemoglobinopathy in Southeast Asia. This study aimed to determine whether HbE protects against clinical Plasmodium vivax malaria in Southeast Asia. METHODS: In a case-control study performed in villages along the China-Myanmar border, we determined the prevalence of HbE in 257 villagers who had acute P. vivax infections and in 157 control healthy villagers. RESULTS: HbE in P. vivax patients (17.4%) was significantly less prevalent than in the healthy villager population (36.3%). Moreover, there was a complete lack of HbEE homozygotes in the vivax patients as compared to 9.5% prevalence in the healthy villagers. Using the HbAA group as the reference, both the HbEA heterozygotes and HbEE homozygotes had significantly lower odds of presenting with acute P. vivax infections. Furthermore, HbEA heterozygotes also had significantly lower P. vivax asexual parasite densities. HbEA did not affect the proportion of P. vivax patients with gametocytemia nor the gametocyte densities. CONCLUSIONS: HbE offers significant protection against the occurrence and parasite density of acute P. vivax infections and provides a renewed perspective on P. vivax malaria as a potentially strong driving force behind the high frequencies of HbE in the Kachin population. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/29964138/Hemoglobin_E_protects_against_acute_Plasmodium_vivax_infections_in_a_Kachin_population_at_the_China-Myanmar_border L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(18)30183-X DB - PRIME DP - Unbound Medicine ER -