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Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents.
Mycopathologia 2019; 184(1):121-128M

Abstract

The Mucorales fungi-formerly classified as the zygomycetes-are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often despite surgical and antifungal therapy. Patients with extensive burn injuries are particularly susceptible to skin and soft-tissue infections with these organisms. Here, we present a case of Lichtheimia infection in a patient with extensive full-thickness burns that required significant and repeated surgical debridement successfully treated with isavuconazole and adjunctive topical amphotericin B washes. We also review the available literature on contemporary antifungal treatment for Lichtheimia species and related Mucorales fungi.

Authors+Show Affiliations

Department of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. thie0149@umn.edu. Department of Pediatrics (Division of Pediatric Infectious Diseases and Immunology), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. thie0149@umn.edu.Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. Department of Microbiology & Immunology, University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.Department of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.Department of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.Department of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.Department of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.Department of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. Department of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29967971

Citation

Thielen, Beth K., et al. "Widespread Lichtheimia Infection in a Patient With Extensive Burns: Opportunities for Novel Antifungal Agents." Mycopathologia, vol. 184, no. 1, 2019, pp. 121-128.
Thielen BK, Barnes AMT, Sabin AP, et al. Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents. Mycopathologia. 2019;184(1):121-128.
Thielen, B. K., Barnes, A. M. T., Sabin, A. P., Huebner, B., Nelson, S., Wesenberg, E., & Hansen, G. T. (2019). Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents. Mycopathologia, 184(1), pp. 121-128. doi:10.1007/s11046-018-0281-6.
Thielen BK, et al. Widespread Lichtheimia Infection in a Patient With Extensive Burns: Opportunities for Novel Antifungal Agents. Mycopathologia. 2019;184(1):121-128. PubMed PMID: 29967971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents. AU - Thielen,Beth K, AU - Barnes,Aaron M T, AU - Sabin,Arick P, AU - Huebner,Becky, AU - Nelson,Susan, AU - Wesenberg,Elizabeth, AU - Hansen,Glen T, Y1 - 2018/07/02/ PY - 2018/01/16/received PY - 2018/06/21/accepted PY - 2020/02/01/pmc-release PY - 2018/7/4/pubmed PY - 2019/3/19/medline PY - 2018/7/4/entrez KW - Absidia KW - Burn KW - Isavuconazole KW - Lichtheimia KW - Mucorales SP - 121 EP - 128 JF - Mycopathologia JO - Mycopathologia VL - 184 IS - 1 N2 - The Mucorales fungi-formerly classified as the zygomycetes-are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often despite surgical and antifungal therapy. Patients with extensive burn injuries are particularly susceptible to skin and soft-tissue infections with these organisms. Here, we present a case of Lichtheimia infection in a patient with extensive full-thickness burns that required significant and repeated surgical debridement successfully treated with isavuconazole and adjunctive topical amphotericin B washes. We also review the available literature on contemporary antifungal treatment for Lichtheimia species and related Mucorales fungi. SN - 1573-0832 UR - https://www.unboundmedicine.com/medline/citation/29967971/Widespread_Lichtheimia_Infection_in_a_Patient_with_Extensive_Burns:_Opportunities_for_Novel_Antifungal_Agents L2 - https://dx.doi.org/10.1007/s11046-018-0281-6 DB - PRIME DP - Unbound Medicine ER -