Tags

Type your tag names separated by a space and hit enter

Interstitial lung disease in non-sicca onset primary Sjögren's syndrome: a large-scale case-control study.
Int J Rheum Dis. 2018 Jul; 21(7):1423-1429.IJ

Abstract

AIM

This study investigated the common initial clinical presentations of primary Sjögren's syndrome (pSS) with interstitial lung disease (ILD) and explored differences between sicca and non-sicca onset pSS-ILD patients.

METHOD

A total of 1341 SS patients hospitalized between 2003 and 2012 were retrospectively reviewed. Of them, 102 were analyzed and recruited to examine the differences between non-sicca and sicca onset.

RESULTS

Fifty-one percent of pSS-ILD patients presented with non-sicca onset. Although the mean diagnosis time was equal, only 4% of non-sicca onset patients were diagnosed with pSS at onset versus 34% with sicca onset (P = 0.000). Hyperglobulinemia, elevated rheumatoid factor (RF) titer, and anti-SSA and/or anti-SSB presence were less predominant in patients with non-sicca onset (immunoglobulin G, 16 [12-21] vs. 21 [15-28] g/L, P = 0.032; RF, 22 [20-171] vs. 104 [20-237] IU/mL, P = 0.048; anti-SSA and/or anti-SSB presence, 33% vs. 72%, P = 0.000). The usual interstitial pneumonia pattern was more commonly seen in non-sicca onset patients (20.0% vs. 14.3%). The high-resolution computed tomography score was higher (12 [88-15] vs. 8 [5-13], P = 0.070) and predicted total lung capacity and forced vital capacity were lower (87 ± 23% vs. 97 ± 20%, P = 0.050; 88 ± 28% vs. 100 ± 27%, P = 0.089) in non-sicca patients.

CONCLUSION

Non-sicca is a common initial manifestation in pSS-ILD. Anti-SSA presence, elevated RF titer and hyperglobulinemia were less predominant, and pulmonary complications were more progressive and severe in non-sicca onset patients than sicca onset patients.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.Department of Radiology, Peking University People's Hospital, Beijing, China.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. Beijing Key Laboratory for Rheumatism (BZ0135), Peking University People's Hospital, Beijing, China.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

29968329

Citation

Gao, Hui, et al. "Interstitial Lung Disease in Non-sicca Onset Primary Sjögren's Syndrome: a Large-scale Case-control Study." International Journal of Rheumatic Diseases, vol. 21, no. 7, 2018, pp. 1423-1429.
Gao H, Zou YD, Zhang XW, et al. Interstitial lung disease in non-sicca onset primary Sjögren's syndrome: a large-scale case-control study. Int J Rheum Dis. 2018;21(7):1423-1429.
Gao, H., Zou, Y. D., Zhang, X. W., He, J., Zhang, J., Sun, Y., & Li, Z. G. (2018). Interstitial lung disease in non-sicca onset primary Sjögren's syndrome: a large-scale case-control study. International Journal of Rheumatic Diseases, 21(7), 1423-1429. https://doi.org/10.1111/1756-185X.13334
Gao H, et al. Interstitial Lung Disease in Non-sicca Onset Primary Sjögren's Syndrome: a Large-scale Case-control Study. Int J Rheum Dis. 2018;21(7):1423-1429. PubMed PMID: 29968329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interstitial lung disease in non-sicca onset primary Sjögren's syndrome: a large-scale case-control study. AU - Gao,Hui, AU - Zou,Ya-Dan, AU - Zhang,Xue-Wu, AU - He,Jing, AU - Zhang,Jing, AU - Sun,Ye, AU - Li,Zhan-Guo, PY - 2018/7/4/entrez PY - 2018/7/4/pubmed PY - 2018/10/30/medline KW - first manifestation KW - interstitial lung disease KW - non-sicca onset KW - primary Sjögren's syndrome SP - 1423 EP - 1429 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 21 IS - 7 N2 - AIM: This study investigated the common initial clinical presentations of primary Sjögren's syndrome (pSS) with interstitial lung disease (ILD) and explored differences between sicca and non-sicca onset pSS-ILD patients. METHOD: A total of 1341 SS patients hospitalized between 2003 and 2012 were retrospectively reviewed. Of them, 102 were analyzed and recruited to examine the differences between non-sicca and sicca onset. RESULTS: Fifty-one percent of pSS-ILD patients presented with non-sicca onset. Although the mean diagnosis time was equal, only 4% of non-sicca onset patients were diagnosed with pSS at onset versus 34% with sicca onset (P = 0.000). Hyperglobulinemia, elevated rheumatoid factor (RF) titer, and anti-SSA and/or anti-SSB presence were less predominant in patients with non-sicca onset (immunoglobulin G, 16 [12-21] vs. 21 [15-28] g/L, P = 0.032; RF, 22 [20-171] vs. 104 [20-237] IU/mL, P = 0.048; anti-SSA and/or anti-SSB presence, 33% vs. 72%, P = 0.000). The usual interstitial pneumonia pattern was more commonly seen in non-sicca onset patients (20.0% vs. 14.3%). The high-resolution computed tomography score was higher (12 [88-15] vs. 8 [5-13], P = 0.070) and predicted total lung capacity and forced vital capacity were lower (87 ± 23% vs. 97 ± 20%, P = 0.050; 88 ± 28% vs. 100 ± 27%, P = 0.089) in non-sicca patients. CONCLUSION: Non-sicca is a common initial manifestation in pSS-ILD. Anti-SSA presence, elevated RF titer and hyperglobulinemia were less predominant, and pulmonary complications were more progressive and severe in non-sicca onset patients than sicca onset patients. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/29968329/Interstitial_lung_disease_in_non_sicca_onset_primary_Sjögren's_syndrome:_a_large_scale_case_control_study_ L2 - https://doi.org/10.1111/1756-185X.13334 DB - PRIME DP - Unbound Medicine ER -