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Healthy aging and carotid performance: strain measures and β-stiffness index.
Hypertens Res. 2018 Sep; 41(9):748-755.HR

Abstract

Arterial stiffness is related to the risk of cardiovascular disease (CVD) and increases with aging. Functional impairment of the arterial wall can occur before structural changes and can be detectable before CVD symptoms. The elastic properties of the carotid arterial wall during the cardiac cycle can be evaluated by standard 2-dimensional (2D) ultrasound longitudinal or circumferential imaging of vascular deformation (strain) using speckle tracking. The purpose of this study was to compare standard 2D ultrasound circumferential and longitudinal images of vascular tissue motion and strain using speckle tracking in young and older individuals. Participants underwent recording of 2D ultrasound circumferential and longitudinal images of the common carotid artery. Circumferential carotid strain (CS) and CS rate were obtained and analyzed via speckle tracking software. Following the strain analysis, the circumferential strain β-stiffness (C-β) was calculated. Conventional longitudinal β-stiffness (L-β) was calculated and non-invasive blood pressure measurements were obtained from carotid artery pressure measurements in a resting supine position using applanation tonometry. C-β was significantly higher than L-β, and the association with age was greater (r = .824 vs. r = .547). CS and CS rate were significantly higher in the young compared to the older group. L-β does not explain as much of the age-dependent differences in the carotid artery compared with C-β. This is possibly due to the inclusion of whole arterial wall motion and deformation observed in the CS image. The ability of C-β to accurately predict the future risk of CVD independent of age still needs further investigation.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA. arosenb12@gmail.com.Department of Preventive Medicine, Northwestern University, Chicago, IL, USA.Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA. Department of Kinesiology, California State University San Bernardino, San Bernardino, CA, USA.Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA. Department of Biomedical Sciences, University of Houston-Victoria, Victoria, TX, USA.Department of General Practice, Intellectual Disability Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA.Department of Kinesiology and Nutrition, Integrative Physiology Laboratory, University of Illinois at Chicago, Chicago, IL, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29968848

Citation

Rosenberg, Alexander J., et al. "Healthy Aging and Carotid Performance: Strain Measures and Β-stiffness Index." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 41, no. 9, 2018, pp. 748-755.
Rosenberg AJ, Lane-Cordova AD, Wee SO, et al. Healthy aging and carotid performance: strain measures and β-stiffness index. Hypertens Res. 2018;41(9):748-755.
Rosenberg, A. J., Lane-Cordova, A. D., Wee, S. O., White, D. W., Hilgenkamp, T. I. M., Fernhall, B., & Baynard, T. (2018). Healthy aging and carotid performance: strain measures and β-stiffness index. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 41(9), 748-755. https://doi.org/10.1038/s41440-018-0065-x
Rosenberg AJ, et al. Healthy Aging and Carotid Performance: Strain Measures and Β-stiffness Index. Hypertens Res. 2018;41(9):748-755. PubMed PMID: 29968848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healthy aging and carotid performance: strain measures and β-stiffness index. AU - Rosenberg,Alexander J, AU - Lane-Cordova,Abbi D, AU - Wee,Sang Ouk, AU - White,Daniel W, AU - Hilgenkamp,Thessa I M, AU - Fernhall,Bo, AU - Baynard,Tracy, Y1 - 2018/07/03/ PY - 2017/07/31/received PY - 2018/02/18/accepted PY - 2018/02/01/revised PY - 2018/7/4/pubmed PY - 2019/9/5/medline PY - 2018/7/4/entrez SP - 748 EP - 755 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens. Res. VL - 41 IS - 9 N2 - Arterial stiffness is related to the risk of cardiovascular disease (CVD) and increases with aging. Functional impairment of the arterial wall can occur before structural changes and can be detectable before CVD symptoms. The elastic properties of the carotid arterial wall during the cardiac cycle can be evaluated by standard 2-dimensional (2D) ultrasound longitudinal or circumferential imaging of vascular deformation (strain) using speckle tracking. The purpose of this study was to compare standard 2D ultrasound circumferential and longitudinal images of vascular tissue motion and strain using speckle tracking in young and older individuals. Participants underwent recording of 2D ultrasound circumferential and longitudinal images of the common carotid artery. Circumferential carotid strain (CS) and CS rate were obtained and analyzed via speckle tracking software. Following the strain analysis, the circumferential strain β-stiffness (C-β) was calculated. Conventional longitudinal β-stiffness (L-β) was calculated and non-invasive blood pressure measurements were obtained from carotid artery pressure measurements in a resting supine position using applanation tonometry. C-β was significantly higher than L-β, and the association with age was greater (r = .824 vs. r = .547). CS and CS rate were significantly higher in the young compared to the older group. L-β does not explain as much of the age-dependent differences in the carotid artery compared with C-β. This is possibly due to the inclusion of whole arterial wall motion and deformation observed in the CS image. The ability of C-β to accurately predict the future risk of CVD independent of age still needs further investigation. SN - 1348-4214 UR - https://www.unboundmedicine.com/medline/citation/29968848/Healthy_aging_and_carotid_performance:_strain_measures_and_β_stiffness_index_ L2 - http://dx.doi.org/10.1038/s41440-018-0065-x DB - PRIME DP - Unbound Medicine ER -