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Single contaminant and combined exposures of polyethylene microplastics and fluoranthene: accumulation and oxidative stress response in the blue mussel, Mytilus edulis.
J Toxicol Environ Health A. 2018; 81(16):761-773.JT

Abstract

The microplastic "vector effect" has received increasing attention. The aim of this study was to investigate the influence of polyethylene microplastic beads (PE MP) on accumulation and associated oxidative stress responses attributed to fluoranthene (Flu) in blue mussels, Mytilus edulis. Blue mussels were exposed for 96 h to four treatment groups: Flu-only, MP-only, Flu and MP coexposure, and Flu-incubated MP. Treatments were conducted at a low and high concentration (50 μg/L and 100 Flu μg/L and 100, and 1000 MP/mL). Results demonstrated that in both the gill and digestive gland, coexposure did not markedly affect Flu uptake, but this treatment significantly decreased tissue Flu concentrations. Antioxidant responses including activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidases (GPx), and levels of total glutathione (GSH) in both gills and digestive glands were significantly altered suggesting a perturbation of redox state induced by the exposure conditions. Although individual biomarkers varied, the biomarker profile enabled certain generalizations to be made. Antioxidant responses occurred more likely in gill tissue than in digestive gland. Individual contaminant exposures to Flu or MP led to varying responses, but coexposures and incubated exposures did not result in additive or synergistic effects. Exposure concentrations (i.e., low or high treatments) were not a consistent a predictor of response; and the internal Flu dose did not consistently predict outcome of various biomarkers. Importantly, MP-only exposure appeared to be capable of eliciting direct effects on the oxidative stress system as demonstrated by the activities of CAT and GPx. These findings warrant further investigation.

Authors+Show Affiliations

a Department of Chemistry, Biology and Biotechnology , University of Perugia , Perugia , Italy.a Department of Chemistry, Biology and Biotechnology , University of Perugia , Perugia , Italy.b Department of Science and Environment , Roskilde University , Roskilde , Denmark.b Department of Science and Environment , Roskilde University , Roskilde , Denmark.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29969377

Citation

Magara, Gabriele, et al. "Single Contaminant and Combined Exposures of Polyethylene Microplastics and Fluoranthene: Accumulation and Oxidative Stress Response in the Blue Mussel, Mytilus Edulis." Journal of Toxicology and Environmental Health. Part A, vol. 81, no. 16, 2018, pp. 761-773.
Magara G, Elia AC, Syberg K, et al. Single contaminant and combined exposures of polyethylene microplastics and fluoranthene: accumulation and oxidative stress response in the blue mussel, Mytilus edulis. J Toxicol Environ Health A. 2018;81(16):761-773.
Magara, G., Elia, A. C., Syberg, K., & Khan, F. R. (2018). Single contaminant and combined exposures of polyethylene microplastics and fluoranthene: accumulation and oxidative stress response in the blue mussel, Mytilus edulis. Journal of Toxicology and Environmental Health. Part A, 81(16), 761-773. https://doi.org/10.1080/15287394.2018.1488639
Magara G, et al. Single Contaminant and Combined Exposures of Polyethylene Microplastics and Fluoranthene: Accumulation and Oxidative Stress Response in the Blue Mussel, Mytilus Edulis. J Toxicol Environ Health A. 2018;81(16):761-773. PubMed PMID: 29969377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single contaminant and combined exposures of polyethylene microplastics and fluoranthene: accumulation and oxidative stress response in the blue mussel, Mytilus edulis. AU - Magara,Gabriele, AU - Elia,Antonia Concetta, AU - Syberg,Kristian, AU - Khan,Farhan R, Y1 - 2018/07/03/ PY - 2018/7/4/pubmed PY - 2019/8/23/medline PY - 2018/7/4/entrez KW - Microplastics vector effect KW - Mytilus edulis KW - PAHs KW - accumulation KW - biomarker profile SP - 761 EP - 773 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 81 IS - 16 N2 - The microplastic "vector effect" has received increasing attention. The aim of this study was to investigate the influence of polyethylene microplastic beads (PE MP) on accumulation and associated oxidative stress responses attributed to fluoranthene (Flu) in blue mussels, Mytilus edulis. Blue mussels were exposed for 96 h to four treatment groups: Flu-only, MP-only, Flu and MP coexposure, and Flu-incubated MP. Treatments were conducted at a low and high concentration (50 μg/L and 100 Flu μg/L and 100, and 1000 MP/mL). Results demonstrated that in both the gill and digestive gland, coexposure did not markedly affect Flu uptake, but this treatment significantly decreased tissue Flu concentrations. Antioxidant responses including activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidases (GPx), and levels of total glutathione (GSH) in both gills and digestive glands were significantly altered suggesting a perturbation of redox state induced by the exposure conditions. Although individual biomarkers varied, the biomarker profile enabled certain generalizations to be made. Antioxidant responses occurred more likely in gill tissue than in digestive gland. Individual contaminant exposures to Flu or MP led to varying responses, but coexposures and incubated exposures did not result in additive or synergistic effects. Exposure concentrations (i.e., low or high treatments) were not a consistent a predictor of response; and the internal Flu dose did not consistently predict outcome of various biomarkers. Importantly, MP-only exposure appeared to be capable of eliciting direct effects on the oxidative stress system as demonstrated by the activities of CAT and GPx. These findings warrant further investigation. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/29969377/Single_contaminant_and_combined_exposures_of_polyethylene_microplastics_and_fluoranthene:_accumulation_and_oxidative_stress_response_in_the_blue_mussel_Mytilus_edulis_ L2 - https://www.tandfonline.com/doi/full/10.1080/15287394.2018.1488639 DB - PRIME DP - Unbound Medicine ER -