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The effects of spironolactone on adrenal steroidogenesis in hirsute women.
Fertil Steril. 1985 Nov; 44(5):595-9.FS

Abstract

The effect of spironolactone on adrenal androgen and cortisol production was studied in six hirsute women. Hirsute women were evaluated before and 1 month after receiving 200 mg of spironolactone daily. Basal levels of serum androgens, 17-hydroxyprogesterone (17-OHP), cortisol (F), corticosteroid-binding globulin, and plasma adrenocorticotropic hormone (ACTH) were normal and did not change with therapy. The delta maximum (delta max) responses after dexamethasone suppression and ACTH administration of dehydroepiandrosterone (DHEA), androstenedione (delta 4A), 17-hydroxypregnenolone, and 17-OHP were similar in hirsute women and ovulatory control subjects. After spironolactone administration, the delta max DHEA response was unchanged, whereas the delta max delta 4A response was decreased (P less than 0.05). The delta max ratios of DHEA/delta 4A and 17-OHP/delta 4A were significantly increased after spironolactone in hirsute women, which suggested inhibitions of 3 beta-ol-dehydrogenase-isomerase and delta 4 17,20 desmolase activities. A significant reduction in delta max F occurred after spironolactone administration (P less than 0.05). Although baseline 11-desoxycortisol (S) and the plasma S/ACTH ratio were unaltered, the delta max S/F ratio increased after treatment (P less than 0.01), suggesting an inhibition of 11 beta-hydroxylase activity. Inhibition of adrenal androgen production occurs with spironolactone, but only serum levels of delta 4A are decreased, whereas DHEA and its sulfate (DHEA-S) levels remain unchanged.

Authors

Serafini P
No affiliation info available
Lobo RA
No affiliation info available

MeSH

17-alpha-HydroxyprogesteroneAdrenal GlandsAdrenocorticotropic HormoneAdultAndrogensAndrostenedioneCortodoxoneDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleHirsutismHumansHydrocortisoneHydroxyprogesteronesSpironolactoneSteroidsTime Factors

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2996951

Citation

Serafini, P, and R A. Lobo. "The Effects of Spironolactone On Adrenal Steroidogenesis in Hirsute Women." Fertility and Sterility, vol. 44, no. 5, 1985, pp. 595-9.
Serafini P, Lobo RA. The effects of spironolactone on adrenal steroidogenesis in hirsute women. Fertil Steril. 1985;44(5):595-9.
Serafini, P., & Lobo, R. A. (1985). The effects of spironolactone on adrenal steroidogenesis in hirsute women. Fertility and Sterility, 44(5), 595-9.
Serafini P, Lobo RA. The Effects of Spironolactone On Adrenal Steroidogenesis in Hirsute Women. Fertil Steril. 1985;44(5):595-9. PubMed PMID: 2996951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of spironolactone on adrenal steroidogenesis in hirsute women. AU - Serafini,P, AU - Lobo,R A, PY - 1985/11/1/pubmed PY - 1985/11/1/medline PY - 1985/11/1/entrez SP - 595 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 44 IS - 5 N2 - The effect of spironolactone on adrenal androgen and cortisol production was studied in six hirsute women. Hirsute women were evaluated before and 1 month after receiving 200 mg of spironolactone daily. Basal levels of serum androgens, 17-hydroxyprogesterone (17-OHP), cortisol (F), corticosteroid-binding globulin, and plasma adrenocorticotropic hormone (ACTH) were normal and did not change with therapy. The delta maximum (delta max) responses after dexamethasone suppression and ACTH administration of dehydroepiandrosterone (DHEA), androstenedione (delta 4A), 17-hydroxypregnenolone, and 17-OHP were similar in hirsute women and ovulatory control subjects. After spironolactone administration, the delta max DHEA response was unchanged, whereas the delta max delta 4A response was decreased (P less than 0.05). The delta max ratios of DHEA/delta 4A and 17-OHP/delta 4A were significantly increased after spironolactone in hirsute women, which suggested inhibitions of 3 beta-ol-dehydrogenase-isomerase and delta 4 17,20 desmolase activities. A significant reduction in delta max F occurred after spironolactone administration (P less than 0.05). Although baseline 11-desoxycortisol (S) and the plasma S/ACTH ratio were unaltered, the delta max S/F ratio increased after treatment (P less than 0.01), suggesting an inhibition of 11 beta-hydroxylase activity. Inhibition of adrenal androgen production occurs with spironolactone, but only serum levels of delta 4A are decreased, whereas DHEA and its sulfate (DHEA-S) levels remain unchanged. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/2996951/The_effects_of_spironolactone_on_adrenal_steroidogenesis_in_hirsute_women_ DB - PRIME DP - Unbound Medicine ER -